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SEQUENCES
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SEQUENCE ANALYSIS
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STRUCTURES
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StabMutAnalyser
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&
ligands
LIGANDS & BIOACTIVITIES
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&
indications
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SEQUENCES
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COUPLINGS
Couplings
COUPLING ANALYSIS
Coupling selectivity (tree)
Coupling selectivity (Venn)
SEQUENCES
Sequence alignments
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STRUCTURES
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STRUCTURE ANALYSIS
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DETERMINANTS & MUTATIONS
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Citing Biased Signaling Atlas
GUIDELINES
Community guidelines paper
Reference ligand selection
Template to calculate ligand bias factors
BIASED LIGANDS (for transducer family)
Biased ligand coverage
Biased ligands
Ligand bias rank orders
Ligand pathway profiles (Δlog(Emax/EC50))
BIASED LIGANDS (for transducer subtype)
Biased ligand coverage
Biased ligands
Ligand bias rank orders
Ligand pathway profiles (Δlog(Emax/EC50))
PATHWAY-PREFERRING LIGANDS (for transducer family)
Pathway-preferring ligand coverage
Pathway-preferring ligands (pathway ∆Log/(Emax/EC50)
Ligand pathway preference rank orders (Δlog(Emax/EC50))
Ligand pathway profiles (Log(Emax/EC50))
Pathways
Pathway effects
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Download
Excel (xlsx)
Alignment (fasta)
Spreadsheet (csv)
Residue number
Sequence-based ()
Structure-based (GPCRdb)
[Olive baboon] S-antigen visual arrestin
[Green monkey] S-antigen visual arrestin
[Bovine] S-arrestin
[Dog] S-arrestin
[Human] S-arrestin
[American bullfrog] S-arrestin
[Northern leopard frog] S-arrestin
[Mouse] S-arrestin
[Pig] S-arrestin
[Rat] S-arrestin
[African clawed frog] S-arrestin
[Horse] Autophagy related 16 like 1
[Northern white-cheeked gibbon] S-antigen visual arrestin
[Western lowland gorilla] S-antigen visual arrestin
[Small-eared galago] S-antigen visual arrestin
[Sumatran orangutan] S-antigen visual arrestin
[Chimpanzee] S-antigen visual arrestin
[Longfin inshore squid] Visual arrestin
[Blind cave fish] S-antigen; retina and pineal gland (arrestin) b
Residue number
Sequence-based ()
Structure-based (GPCRdb)
Seq consensus
Prop consensus
Length
RESIDUE PROPERTIES & LENGTH
Hydrophobic
HY
any
Hydrophobic
HY
4-5
Hydrophobic aliphatic
HA
any
Hydrophobic aliphatic
HA
1-2
Hydrophobic aliphatic
HA
2-3
Hydrophobic aliphatic
HA
3
Hydrophobic aliphatic
HA
3-4
Hydrophobic aliphatic [M]
M
4
Hydrophob al / α-H prop - very high [A]
A
1
Hydrophobic aliphatic [I]
I
Hydrophobic aliphatic [L]
L
Hydrophobic aliphatic [V]
V
Hydrophobic aromatic
HR
any
Hydrophobic aromatic
HR
4-5
Hydrophobic aromatic
HR
5
Hydrophobic aromatic
HR
5-6
Hydrophobic aromatic [W]
W
6
Hydropob ar / H-bonding [Y]
Y
Hydrophobic aromatic [F]
F
Hydrogen bonding (polar)
Hb
any
Hydrogen bonding
Hb
2
Hydrogen bonding
Hb
3
Hydrogen bonding [N]
N
Hydrogen bonding [Q]
Q
Hydrogen bonding [S]
S
Hydrogen bonding [T]
T
Hydrogen bonding uncharged
Hu
2-3
Hydrogen bonding uncharged
Hu
3-4
Hydrogen bond acceptor
Ha
2-3
Hydrogen bond acceptor
Ha
3
Hydrogen bond acceptor
Ha
3-4
Hydrogen bond acceptor
Ha
4
Hydrogen bond donor
Hd
4
Hydrogen bond donor
Hd
4-5
Hydrogen bond donor
Hd
5-6
Hydrogen bond donor
Hd
6
Charged
+-
any
Charged
+-
3-4
Charged
+-
4-5
Charged positive
+
any
Charged pos / H bond / Hphob ar [H]
H
4
Charged positive
+
4-5
Charged positive [K]
K
5
Charged positive
+
5-6
Charged positive [R]
R
6
Charged negative
-
any
Charged negative [D]
D
3
Charged negative [E]
E
4
Small
Sm
any
Small
Sm
0-1
Small
Sm
1-2
α-Helix propensity - high
αH
Hig
α-Helix propensity - low
αH
Min
α-Helix flexibility [G]
G
0
α-Helix kink [P]
P
2
Disulfide-forming (S-S) [C]
C
2
Gap (no amino acid)
-
RESIDUE Z-SCALES
Z1 (Lipophilicity)
Z2 (Steric properties)
Z3 (Electronic properties)
Z4 (PC1 several properties)
Z5 (PC2 several properties)
Residue number
Sequence-based ()
Structure-based (GPCRdb)
ns1
S1
s1s2
S2
s2s3
S3
s3s4
S4
s4s5
S5
s5s6
S6
s6h1
H1
h1s7
S7
s7s8
S8
s8s9
S9
s9s10
S10
s10s11
S11
s11s12
S12
s12s13
S13
s13s14
S14
s14s15
S15
s15s16
S16
s16s17
S17
s17s18
S18
s18s19
S19
s19s20
S20
s20c
N.ns1.01
N.ns1.02
N.ns1.03
N.ns1.04
N.ns1.05
N.ns1.06
N.ns1.07
N.ns1.08
N.ns1.09
N.ns1.10
N.ns1.11
N.ns1.12
N.ns1.13
N.ns1.14
N.ns1.15
N.S1.01
N.S1.02
N.S1.03
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N.S1.05
N.s1s2.01
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N.s1s2.03
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N.S2.01
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N.S3.01
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N.S3.03
N.S3.04
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N.H1.01
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N.h1s7.01
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N.S7.01
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N.S10.01
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C.s10s11.01
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C.S16.01
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C.S18.01
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M
A
A
S
G
K
T
S
K
S
E
P
N
H
V
I
F
K
K
I
S
R
D
K
S
V
T
I
Y
L
G
K
R
D
Y
I
D
H
V
S
Q
V
Q
P
V
D
G
V
V
L
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D
P
D
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K
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C
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G
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D
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G
L
A
F
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D
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P
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G
-
-
A
A
S
T
P
T
K
L
Q
E
S
L
L
K
K
L
G
S
N
T
Y
P
F
L
L
T
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P
D
Y
L
P
C
S
V
M
L
Q
P
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P
Q
D
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G
K
S
C
G
V
D
F
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D
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A
D
D
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_
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C.S16.05
C.S16.06
C.S16.07
C.S16.08
C.S16.09
C.S16.10
C.S16.11
C.S16.12
C.S16.13
C.S16.14
C.s16s17.01
C.s16s17.02
C.s16s17.03
C.s16s17.04
C.s16s17.05
C.s16s17.06
C.s16s17.07
C.s16s17.08
C.S17.01
C.S17.02
C.S17.03
C.S17.04
C.S17.05
C.S17.06
C.S17.07
C.S17.08
C.S17.09
C.s17s18.01
C.s17s18.02
C.s17s18.03
C.s17s18.04
C.s17s18.05
C.s17s18.06
C.s17s18.07
C.s17s18.08
C.s17s18.09
C.s17s18.10
C.s17s18.11
C.s17s18.12
C.s17s18.13
C.s17s18.14
C.s17s18.15
C.s17s18.16
C.s17s18.17
C.s17s18.18
C.s17s18.19
C.s17s18.20
C.s17s18.21
C.s17s18.22
C.s17s18.23
C.s17s18.24
C.s17s18.25
C.s17s18.26
C.s17s18.27
C.s17s18.28
C.s17s18.29
C.s17s18.30
C.s17s18.31
C.s17s18.32
C.s17s18.33
C.s17s18.34
C.s17s18.35
C.s17s18.36
C.s17s18.37
C.s17s18.38
C.s17s18.39
C.s17s18.40
C.s17s18.41
C.s17s18.42
C.S18.01
C.S18.02
C.S18.03
C.S18.04
C.S18.05
C.S18.06
C.S18.07
C.S18.08
C.S18.09
C.S18.10
C.S18.11
C.S18.12
C.S18.13
C.s18s19.01
C.s18s19.02
C.s18s19.03
C.s18s19.04
C.s18s19.05
C.s18s19.06
C.s18s19.07
C.s18s19.08
C.s18s19.09
C.s18s19.10
C.s18s19.11
C.S19.01
C.S19.02
C.S19.03
C.S19.04
C.S19.05
C.S19.06
C.S19.07
C.S19.08
C.S19.09
C.S19.10
C.S19.11
C.S19.12
C.S19.13
C.s19s20.01
C.s19s20.02
C.s19s20.03
C.s19s20.04
C.s19s20.05
C.s19s20.06
C.s19s20.07
C.s19s20.08
C.s19s20.09
C.s19s20.10
C.s19s20.11
C.s19s20.12
C.s19s20.13
C.s19s20.14
C.s19s20.15
C.s19s20.16
C.s19s20.17
C.s19s20.45
C.s19s20.46
C.s19s20.47
C.s19s20.48
C.s19s20.49
C.s19s20.50
C.s19s20.51
C.S20.01
C.S20.02
C.S20.03
C.S20.04
C.S20.05
C.s20c.01
C.s20c.02
C.s20c.03
C.s20c.04
C.s20c.05
C.s20c.06
C.s20c.07
C.s20c.08
C.s20c.09
C.s20c.10
C.s20c.11
C.s20c.12
C.s20c.13
C.s20c.14
C.s20c.15
C.s20c.16
C.s20c.17
C.s20c.18
C.s20c.19
C.s20c.20
C.s20c.21
C.s20c.22
C.s20c.23
C.s20c.24
C.s20c.25
M
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68
68
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11
21
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11
0
5
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63
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5
95
100
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5
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100
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21
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84
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5
74
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47
79
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11
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42
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42
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74
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100
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100
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100
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100
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26
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68
0
89
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5
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79
53
95
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100
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100
0
0
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100
100
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100
53
100
0
100
16
0
5
89
100
100
0
0
0
79
100
68
100
11
100
16
100
0
0
5
0
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11
100
0
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100
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89
58
100
5
0
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84
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100
100
100
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5
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100
79
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74
100
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68
5
5
47
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5
5
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74
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5
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5
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11
100
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100
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21
0
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5
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100
100
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0
0
0
100
0
5
0
0
0
5
100
100
5
0
0
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5
5
0
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5
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100
0
100
100
100
0
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0
100
5
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0
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5
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5
5
0
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89
0
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84
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5
0
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100
79
11
0
100
100
100
21
100
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5
95
0
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0
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74
63
11
21
11
5
5
0
0
0
0
0
5
0
79
5
0
47
0
95
95
95
0
0
95
89
0
5
11
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0
0
63
16
0
74
5
0
0
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5
0
0
5
26
63
11
0
0
68
5
0
0
11
16
0
0
5
5
0
0
0
0
0
5
100
0
0
0
0
0
0
0
0
0
0
0
100
0
0
0
0
0
100
5
0
0
0
0
5
0
0
0
0
0
0
0
0
16
0
0
0
0
5
0
0
0
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100
0
5
0
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0
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100
0
100
0
0
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11
0
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21
0
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100
0
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5
95
89
0
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5
0
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100
0
0
0
0
0
0
0
11
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0
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21
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5
21
0
95
0
0
89
0
0
0
0
0
74
0
0
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0
5
5
0
5
0
0
0
0
0
0
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100
0
0
0
0
100
0
0
0
0
5
0
0
0
0
0
0
11
0
0
0
0
0
0
0
0
5
0
0
0
0
0
26
5
0
5
0
74
0
0
0
0
0
0
0
0
0
0
0
100
95
100
0
0
0
0
5
0
5
0
0
0
0
0
0
0
0
100
100
0
0
0
0
5
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
37
0
0
0
0
0
0
0
0
0
100
0
0
0
89
100
0
0
0
0
0
47
0
0
0
0
0
0
5
0
0
0
0
0
0
0
0
21
0
0
0
26
0
0
0
0
0
0
0
16
0
0
0
0
0
0
0
0
0
0
0
0
0
0
5
0
0
0
5
0
0
0
0
0
0
0
0
0
0
5
0
0
0
0
42
0
5
0
0
0
100
0
0
0
0
0
5
5
0
0
5
0
0
68
0
0
0
16
0
0
0
0
5
0
0
0
0
0
100
0
0
95
0
0
0
0
0
0
0
0
0
16
0
5
0
0
0
0
0
0
0
0
58
0
0
5
0
26
0
95
0
0
95
0
0
0
0
0
0
0
11
0
0
11
0
0
0
0
0
0
0
5
0
5
5
0
0
68
68
68
0
21
16
11
0
5
11
16
5
0
5
95
100
0
0
0
74
0
0
0
0
16
100
0
95
0
100
5
0
0
0
0
95
0
0
89
0
0
95
0
0
100
0
0
100
95
84
100
0
0
0
89
95
0
0
0
0
100
0
95
11
100
5
5
95
0
0
0
0
0
0
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100
0
100
100
0
100
16
0
0
0
0
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5
11
16
0
84
0
100
0
0
0
100
0
0
5
74
79
0
32
26
0
0
100
0
11
0
100
100
0
0
100
0
11
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1.1
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1.5
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1.8
0.3
0.3
1.9
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0.9
1.3
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0.3
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0.2
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0.7
0.6
0.9
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0.6
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0.4
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0.6
1.5
0.1
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1.0
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0.4
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1.2
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0.2
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0.9
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1.0
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1.8
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1.9
0.4
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1.9
1.8
1.1
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0.4
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-2.6
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0.5
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3.5
0.5
1.1
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0.4
0.4
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1.9
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1.9
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0.4
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1.1
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1.9
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0.5
0.8
1.0
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0.6
1.8
1.8
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0.1
1.9
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0.8
0.1
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0.5
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0.4
0.8
1.0
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0.4
1.8
1.1
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0.9
1.8
1.8
0.5
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1.8
3.7
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0.8
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1.8
0.5
1.5
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1.9
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0.4
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1.5
3.8
0.4
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1.8
1.0
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0.5
1.0
0.7
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1.5
1.0
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1.6
0.7
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0.1
1.8
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1.3
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1.1
1.1
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0.3
0.6
1.7
0.1
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0.7
0.4
1.7
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1.8
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0.6
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0.1
0.7
0.6
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1.1
0.8
0.5
1.0
1.9
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1.8
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0.2
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1.0
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1.1
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0.0
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0.5
0.8
0.3
0.4
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1.3
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1.1
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-0.6
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-0.8
1.0
0.9
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0.2
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-1.4
-2.5
-2.1
-1.7
-1.8
-0.3
0.3
-1.5
-0.2
-1.4
-1.5
0.4
1.1
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-1.3
-1.5
0.4
1.1
1.0
1.7
0.3
0.4
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-2.4
0.9
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0.5
0.3
0.0
-0.2
-0.1
-0.1
-0.1
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-2.1
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1.0
1.8
0.4
-1.1
1.0
-0.7
-1.1
-1.0
-1.8
-1.2
-0.9
-1.0
-1.5
-1.7
1.8
-1.5
-1.5
0.6
0.8
0.9
-3.3
-0.3
-3.3
-3.3
0.3
-1.7
0.6
-1.5
1.9
0.4
-2.5
-1.7
-2.5
0.3
-0.1
1.9
-1.1
1.0
-1.5
0.6
1.1
1.1
-1.1
-1.6
-1.5
-2.3
-0.0
0.4
-1.5
1.8
-3.3
-1.0
-1.4
-0.7
0.4
-1.6
-1.5
-1.5
1.3
0.4
-1.5
-1.7
-2.5
-1.5
-2.2
-1.3
-1.0
-1.4
1.1
1.1
0.8
0.4
0.3
-1.5
0.4
0.1
-1.0
-1.2
1.1
1.1
-0.0
-1.4
0.5
-1.2
-0.0
-1.5
1.8
1.1
-3.1
-1.5
0.6
0.4
1.8
-1.5
1.7
0.1
1.7
1.3
0.5
-1.8
0.3
0.7
-0.6
0.9
-0.4
-0.1
0.4
1.9
1.9
0.6
-0.1
0.5
-1.2
1.6
0.3
1.2
-0.8
-1.5
1.0
-0.1
0.1
1.1
0.4
-3.5
-0.2
0.9
-1.5
-2.5
1.8
0.2
-0.0
-0.2
0.5
-0.6
-0.1
-0.4
-1.9
-2.3
1.3
-1.5
0.9
1.4
-0.7
0.4
0.5
0.3
1.7
-0.1
-0.1
-1.1
-0.4
1.4
-1.3
-1.2
0.7
-0.6
-1.4
0.2
-0.3
3.0
-0.7
-0.7
0.4
1.5
1.5
-1.0
-1.4
1.9
-2.4
1.4
-1.0
-0.8
-1.4
-0.9
0.0
-0.7
-0.8
1.4
2.0
-2.5
0.1
-0.8
-2.5
3.9
-0.7
-2.0
-0.9
-0.9
-2.3
0.6
-0.8
-2.5
-0.8
-0.8
-0.8
-0.5
-0.8
-2.5
0.7
-2.7
-0.7
-0.9
1.5
-0.8
1.5
1.5
-0.9
0.1
-0.8
-1.2
-0.7
-1.4
0.1
-0.2
0.5
2.0
0.0
-0.8
-1.0
-3.0
-2.5
-0.5
-2.5
-0.9
-0.2
-0.8
-0.7
-1.2
0.5
2.0
1.9
-2.5
-0.7
0.1
0.4
-1.0
1.1
-0.6
-1.3
-0.8
0.1
0.7
0.7
-0.8
-1.4
-2.5
-1.9
-0.7
0.0
-0.6
-0.8
0.4
-1.5
1.2
-0.7
-1.3
-2.8
-0.5
-0.7
-0.2
1.4
1.5
-0.7
-0.8
-1.4
-0.9
-1.1
0.0
0.7
0.5
-0.4
-0.3
-1.5
0.5
0.7
-2.4
-0.1
-0.8
0.7
0.0
-1.4
-0.9
1.2
-0.7
-1.1
0.7
-0.3
0.5
-1.3
-2.5
-1.0
-0.9
1.4
-0.6
0.2
-0.8
-0.9
-2.5
0.5
-3.0
-0.8
1.3
-0.2
0.5
-0.4
-1.0
-1.9
-1.2
-0.8
-2.5
-0.8
-2.9
-3.0
-2.5
1.6
-0.7
1.3
1.5
1.6
-1.3
-1.4
-0.9
1.6
-0.7
-0.6
-0.8
2.0
1.5
-0.8
-1.3
2.9
-0.1
0.5
-0.6
-2.1
1.4
-0.9
0.5
-1.1
0.7
1.5
-0.2
-3.0
-0.5
-0.7
3.2
-1.5
0.5
0.7
1.9
-1.4
-2.4
1.4
0.7
-0.6
2.9
-0.6
-0.8
-0.7
-1.4
-0.7
-1.2
1.5
-2.9
-0.7
0.1
0.4
3.6
-0.8
-3.0
0.2
-0.7
0.3
-0.8
-1.3
-0.9
-1.3
-0.8
-1.6
-1.1
-1.0
-1.4
-2.8
1.5
-1.3
-0.8
1.5
1.2
-0.8
0.9
-0.5
-0.5
-0.8
-2.9
-1.3
-0.9
-0.3
-1.2
-0.8
-0.8
-0.7
0.0
-1.5
-1.4
-2.4
0.1
0.0
-0.8
1.4
0.0
-0.8
-0.2
0.2
-2.9
-2.9
-0.6
-3.0
-3.0
-1.4
-2.8
1.3
-0.8
-0.1
0.5
-0.7
-1.5
-1.3
-1.4
-0.5
-0.9
1.3
-1.4
-0.4
-1.2
-0.7
-0.5
0.7
-0.7
-0.7
-0.4
-1.0
-1.2
1.8
-2.8
1.9
1.9
-1.2
-0.8
-0.1
-0.7
-2.4
-0.8
1.5
-0.8
1.5
3.7
-3.0
-2.5
-1.5
-1.0
-0.7
-0.1
-1.3
-1.4
-1.5
-0.9
-0.9
1.4
-2.8
-1.0
-0.7
-2.4
1.9
-1.6
-0.9
0.4
-0.8
-0.7
-0.7
-0.9
-1.6
0.0
0.3
-0.8
1.4
-0.8
0.9
-0.6
-1.3
-0.8
-1.3
0.5
-1.1
-0.8
0.3
-0.8
-0.8
-2.6
-0.3
-1.3
-1.3
-1.4
-3.0
-0.7
-0.4
-1.4
-3.0
-0.8
0.7
0.5
1.4
-0.7
1.8
3.5
0.7
-0.8
0.6
-2.6
-2.2
0.5
-0.6
0.4
-1.9
-0.8
-0.7
-1.8
-0.3
-3.0
-0.8
-2.5
-2.5
-0.1
-3.0
-0.4
-1.3
-2.6
-1.5
-1.4
-0.3
-0.8
0.6
-3.0
-3.0
0.5
-0.0
2.0
0.3
-0.7
-0.7
1.5
-2.3
-0.8
-1.1
-2.7
-0.3
-2.2
-2.9
-0.5
0.6
0.5
-2.1
-0.4
-1.8
-1.7
-1.0
-1.1
-2.3
-2.9
-0.8
1.1
1.3
0.2
-0.4
0.1
-0.0
0.7
0.3
0.6
0.1
1.5
1.1
0.2
-0.0
0.2
-0.8
0.3
0.3
0.1
0.7
-0.1
0.8
0.3
0.8
0.0
-0.2
0.2
-1.5
0.8
-0.3
0.4
-0.2
0.8
-1.4
0.1
0.8
0.1
-0.1
0.4
0.4
0.0
0.3
2.0
-0.0
0.8
-0.4
-0.0
-0.2
0.6
-0.0
0.8
2.0
0.3
0.7
0.1
0.3
-0.3
0.3
0.3
-0.0
-1.4
-0.0
-0.1
0.8
-0.3
-2.5
1.2
-0.6
-0.2
-1.5
-0.4
0.7
-0.2
0.8
0.1
0.8
-0.0
0.0
-0.4
0.7
0.1
-0.6
-0.2
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0.8
0.7
-1.2
-0.6
0.6
-0.0
-0.1
0.7
0.1
-1.3
2.0
2.0
0.1
-0.3
0.8
-0.1
1.1
0.8
0.3
-0.0
1.3
-0.4
0.3
0.7
0.7
-0.1
0.5
0.8
0.4
0.4
0.3
0.8
-0.4
0.7
1.5
0.0
-1.3
2.0
-0.6
0.6
0.4
-0.1
-0.5
2.0
0.7
-1.1
0.8
2.0
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0.6
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0.8
0.6
2.0
1.2
1.7
0.5
0.8
0.0
-0.2
0.4
0.3
-2.7
-0.3
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0.7
-0.7
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0.0
0.3
1.2
-0.7
0.9
0.0
0.7
0.7
0.2
0.6
0.8
-0.3
-0.1
0.7
0.2
0.1
1.5
0.3
0.2
0.9
0.7
-0.0
-0.1
0.8
0.8
0.3
-0.2
0.3
0.1
0.7
-0.3
1.1
1.9
0.9
0.0
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-0.3
1.9
0.6
2.0
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1.2
-0.3
0.9
0.9
-1.5
0.6
-0.6
-0.6
-1.0
0.6
0.7
0.3
2.0
0.7
0.3
0.7
0.7
0.1
0.6
0.8
1.0
0.3
-0.1
0.2
-1.3
-0.9
0.1
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-0.2
1.6
0.2
1.4
0.1
-0.0
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-0.0
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1.6
1.4
-0.2
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0.3
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0.0
0.3
0.4
0.3
0.3
0.7
0.2
-0.0
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0.7
0.0
1.1
1.6
-0.0
-0.2
0.8
-1.5
0.6
0.7
0.7
-1.2
-1.5
-0.0
0.3
1.3
-0.0
1.2
-0.4
-0.1
-0.2
0.6
-0.3
-0.3
0.7
-0.2
0.4
-0.0
1.5
1.9
1.3
-0.4
0.6
-0.2
0.4
-0.3
0.2
-0.4
0.4
-0.2
0.8
0.5
2.0
0.8
0.8
1.2
1.0
1.5
-0.1
-0.2
-0.1
-0.1
-0.4
0.3
1.3
0.8
0.8
-0.4
0.3
0.4
0.3
0.0
-0.3
0.8
-0.4
1.5
0.8
1.3
0.7
0.7
-0.4
0.3
0.3
0.4
-0.2
-0.3
0.1
0.8
-0.1
-0.4
0.1
0.1
-0.4
0.2
0.7
-0.0
0.7
-1.5
0.5
0.2
0.3
-0.0
0.2
0.7
-0.4
0.1
0.6
-0.6
0.1
-0.4
-0.3
0.7
-0.4
-0.0
0.5
-0.4
0.7
0.6
-0.2
-0.1
1.1
-0.3
-0.2
0.1
2.0
-0.6
-0.1
0.8
-1.1
0.3
2.0
0.6
1.9
-0.1
0.6
1.5
0.8
0.4
-0.0
0.7
-0.3
0.6
0.4
-0.3
-0.4
0.8
0.8
1.3
-0.3
-0.8
0.7
0.6
0.4
1.4
0.4
-0.0
-0.6
-0.3
-0.1
-0.6
1.2
-0.2
0.5
1.5
0.8
0.3
0.6
0.5
-0.1
-0.0
0.9
-0.2
-0.1
-0.2
0.2
-0.0
0.5
0.2
0.7
0.8
0.1
0.6
0.1
-0.1
N.ns1.01
N.ns1.02
N.ns1.03
N.ns1.04
N.ns1.05
N.ns1.06
N.ns1.07
N.ns1.08
N.ns1.09
N.ns1.10
N.ns1.11
N.ns1.12
N.ns1.13
N.ns1.14
N.ns1.15
N.S1.01
N.S1.02
N.S1.03
N.S1.04
N.S1.05
N.s1s2.01
N.s1s2.02
N.s1s2.03
N.s1s2.04
N.s1s2.05
N.S2.01
N.S2.02
N.S2.03
N.S2.04
N.S2.05
N.s2s3.01
N.s2s3.02
N.s2s3.03
N.S3.01
N.S3.02
N.S3.03
N.S3.04
N.s3s4.01
N.s3s4.02
N.s3s4.03
N.s3s4.04
N.s3s4.05
N.s3s4.06
N.s3s4.07
N.S4.01
N.S4.02
N.S4.03
N.S4.04
N.S4.05
N.S4.06
N.S4.07
N.s4s5.01
N.s4s5.02
N.s4s5.03
N.s4s5.04
N.s4s5.05
N.s4s5.06
N.s4s5.07
N.s4s5.08
N.S5.01
N.S5.02
N.S5.03
N.S5.04
N.S5.05
N.S5.06
N.S5.07
N.S5.08
N.S5.09
N.S5.10
N.S5.11
N.S5.12
N.s5s6.01
N.s5s6.02
N.s5s6.03
N.s5s6.04
N.s5s6.05
N.s5s6.06
N.s5s6.07
N.s5s6.08
N.s5s6.09
N.s5s6.10
N.s5s6.11
N.S6.01
N.S6.02
N.S6.03
N.S6.04
N.S6.05
N.S6.06
N.S6.07
N.S6.08
N.S6.09
N.S6.10
N.S6.11
N.S6.12
N.S6.13
N.s6h1.01
N.s6h1.02
N.s6h1.03
N.s6h1.04
N.s6h1.05
N.s6h1.06
N.s6h1.07
N.s6h1.08
N.s6h1.09
N.s6h1.10
N.s6h1.11
N.s6h1.12
N.H1.01
N.H1.02
N.H1.03
N.H1.04
N.H1.05
N.H1.06
N.H1.07
N.H1.08
N.H1.09
N.H1.10
N.h1s7.01
N.h1s7.02
N.h1s7.03
N.S7.01
N.S7.02
N.S7.03
N.S7.04
N.S7.05
N.S7.06
N.s7s8.01
N.s7s8.02
N.s7s8.03
N.s7s8.04
N.s7s8.05
N.s7s8.06
N.s7s8.07
N.s7s8.08
N.s7s8.09
N.S8.01
N.S8.02
N.S8.03
N.s8s9.01
N.s8s9.02
N.s8s9.03
N.s8s9.04
N.s8s9.05
N.s8s9.06
N.s8s9.07
N.s8s9.08
N.s8s9.09
N.s8s9.10
N.S9.01
N.S9.02
N.S9.03
N.S9.04
N.S9.05
N.S9.06
N.S9.07
N.S9.08
N.S9.09
N.S9.10
N.S9.11
N.S9.12
N.s9s10.01
N.s9s10.02
N.s9s10.03
N.s9s10.04
N.s9s10.05
N.s9s10.06
N.s9s10.07
N.s9s10.08
N.s9s10.09
N.s9s10.10
N.s9s10.11
N.s9s10.12
N.s9s10.13
N.s9s10.14
N.S10.01
N.S10.02
N.S10.03
N.S10.04
N.S10.05
N.S10.06
N.S10.07
N.S10.08
N.S10.09
N.S10.10
N.S10.11
C.s10s11.01
C.s10s11.02
C.s10s11.03
C.s10s11.04
C.s10s11.05
C.s10s11.06
C.s10s11.07
C.s10s11.08
C.s10s11.09
C.s10s11.10
C.S11.01
C.S11.02
C.S11.03
C.S11.04
C.S11.05
C.S11.06
C.s11s12.01
C.s11s12.02
C.s11s12.03
C.s11s12.04
C.s11s12.05
C.s11s12.06
C.s11s12.07
C.S12.01
C.S12.02
C.S12.03
C.S12.04
C.S12.05
C.S12.06
C.S12.07
C.s12s13.01
C.s12s13.02
C.s12s13.03
C.S13.01
C.S13.02
C.S13.03
C.s13s14.01
C.s13s14.02
C.s13s14.03
C.s13s14.04
C.S14.01
C.S14.02
C.S14.03
C.S14.04
C.S14.05
C.S14.06
C.S14.07
C.S14.08
C.S14.09
C.s14s15.01
C.s14s15.02
C.s14s15.03
C.s14s15.04
C.s14s15.05
C.S15.01
C.S15.02
C.S15.03
C.S15.04
C.S15.05
C.S15.06
C.S15.07
C.S15.08
C.S15.09
C.S15.10
C.S15.11
C.S15.12
C.S15.13
C.S15.14
C.s15s16.01
C.s15s16.02
C.s15s16.03
C.s15s16.04
C.s15s16.05
C.S16.01
C.S16.02
C.S16.03
C.S16.04
C.S16.05
C.S16.06
C.S16.07
C.S16.08
C.S16.09
C.S16.10
C.S16.11
C.S16.12
C.S16.13
C.S16.14
C.s16s17.01
C.s16s17.02
C.s16s17.03
C.s16s17.04
C.s16s17.05
C.s16s17.06
C.s16s17.07
C.s16s17.08
C.S17.01
C.S17.02
C.S17.03
C.S17.04
C.S17.05
C.S17.06
C.S17.07
C.S17.08
C.S17.09
C.s17s18.01
C.s17s18.02
C.s17s18.03
C.s17s18.04
C.s17s18.05
C.s17s18.06
C.s17s18.07
C.s17s18.08
C.s17s18.09
C.s17s18.10
C.s17s18.11
C.s17s18.12
C.s17s18.13
C.s17s18.14
C.s17s18.15
C.s17s18.16
C.s17s18.17
C.s17s18.18
C.s17s18.19
C.s17s18.20
C.s17s18.21
C.s17s18.22
C.s17s18.23
C.s17s18.24
C.s17s18.25
C.s17s18.26
C.s17s18.27
C.s17s18.28
C.s17s18.29
C.s17s18.30
C.s17s18.31
C.s17s18.32
C.s17s18.33
C.s17s18.34
C.s17s18.35
C.s17s18.36
C.s17s18.37
C.s17s18.38
C.s17s18.39
C.s17s18.40
C.s17s18.41
C.s17s18.42
C.S18.01
C.S18.02
C.S18.03
C.S18.04
C.S18.05
C.S18.06
C.S18.07
C.S18.08
C.S18.09
C.S18.10
C.S18.11
C.S18.12
C.S18.13
C.s18s19.01
C.s18s19.02
C.s18s19.03
C.s18s19.04
C.s18s19.05
C.s18s19.06
C.s18s19.07
C.s18s19.08
C.s18s19.09
C.s18s19.10
C.s18s19.11
C.S19.01
C.S19.02
C.S19.03
C.S19.04
C.S19.05
C.S19.06
C.S19.07
C.S19.08
C.S19.09
C.S19.10
C.S19.11
C.S19.12
C.S19.13
C.s19s20.01
C.s19s20.02
C.s19s20.03
C.s19s20.04
C.s19s20.05
C.s19s20.06
C.s19s20.07
C.s19s20.08
C.s19s20.09
C.s19s20.10
C.s19s20.11
C.s19s20.12
C.s19s20.13
C.s19s20.14
C.s19s20.15
C.s19s20.16
C.s19s20.17
C.s19s20.45
C.s19s20.46
C.s19s20.47
C.s19s20.48
C.s19s20.49
C.s19s20.50
C.s19s20.51
C.S20.01
C.S20.02
C.S20.03
C.S20.04
C.S20.05
C.s20c.01
C.s20c.02
C.s20c.03
C.s20c.04
C.s20c.05
C.s20c.06
C.s20c.07
C.s20c.08
C.s20c.09
C.s20c.10
C.s20c.11
C.s20c.12
C.s20c.13
C.s20c.14
C.s20c.15
C.s20c.16
C.s20c.17
C.s20c.18
C.s20c.19
C.s20c.20
C.s20c.21
C.s20c.22
C.s20c.23
C.s20c.24
C.s20c.25