Sequence alignments
Alignments with generic residue numbers and residue plots.
Arrestin couplings
Unified coupling atlas and Arrestin selectivity profiles.
Structures
Arrestin structure statistics and browser with unique annotation.
Arrestin structure interface
Structure based coupling interface interactions.
ArrestinDb
Arrestins can 'arrest' signaling by blocking GPCR-mediated G protein coupling and inducing receptor internalization.
They are also scaffold proteins rectruiting and assembling other signaling proteins and can be involved in biased
signaling1
Data
- Sequences
- 4 Human arrestins
- 84 Species orthologs
- 458 Generic residues
- Couplings
- 288 Arrestin couplings
- Structures
- 1,540 Arrestins
- 45 Arrestin complexes
- Structure models
- 1,425 Arrestin structure models
- 1,470 GPCR complexes
- Structure interactions
- 78,041 Interface interactions
- Mutations
- 409 Interface mutations
Overview
Latest release
Sept. 22, 2026- Structures page
- Adds all PDB structures released by July 15th, 2026
- Structure annotation adding auxiliary small molecules & ligand modality
- New, fast and user-friendly interface
- Structure coverage page
- New visualizations
- Structure models (ligand complexes) page
- Drug-GPCR models (from Boltz2)
- Peptide ligand-GPCR models (from AlphaFold)
- Ligands
- Ligand variants and groups
- Persistent ligand identifiers
- Peptide hormone analog bioactivities page
- New ligand bioactivities from literature
- Ligand interactions page
- New interface
- Data mapper page
- Data pasting and editing online
- Other
- Gene names with NCBI Entrez links
- Vomeronasal pheromone receptors added
- Sequence alignments page
- GPCR segment selection visual update
- Receptor page
- Snake plots, vertical helix alignment
- GPCR Classification
- Arrestin-GPCR complex models (from AlphaFold-multimer)
- Phosphorylation site resource
All releases