The four dots depict Arrestin coupling.


Receptor names:

Arrestin complexes
⬤ β-Arrestin1 ⬤ β-Arrestin2 ⬤ Arrestin-C ⬤ S-Arrestin

Class A
(Rhodopsin)

Alicarboxylic acidHydroxycarboxylic acidHCAR1HCAR2HCAR3OxoglutarateOXGR1SuccinateSUCR1Aminergic5-Hydroxytryptamine5HT1A5HT1B5HT1D5HT1E5HT1F5HT2A5HT2B5HT2C5HT4R5HT5A5HT5B5HT6R5HT7RAcetylcholine (muscarinic)ACM1ACM2ACM3ACM4ACM5AdrenoceptorsADA1AADA1BADA1DADA2AADA2BADA2CADRB1ADRB2ADRB3DopamineDRD1DRD2DRD3DRD4DRD5HistamineHRH1HRH2HRH3HRH4Trace amineTAAR1LipidCannabinoidCNR1CNR2Free fatty acidFFAR1FFAR2FFAR3FFAR4GPR42GPR18, GPR55 and GPR119GPR18GPR55GP119LeukotrieneLT4R1LT4R2CLTR1CLTR2OXER1Lysophospholipid (LPA)LPAR1LPAR2LPAR3LPAR4LPAR5LPAR6Lysophospholipid (S1P)S1PR1S1PR2S1PR3S1PR4S1PR5Platelet-activating factorPTAFRProstanoidPD2RPD2R2PE2R1PE2R2PE2R3PE2R4PF2RPI2RTA2RMelatoninMelatoninMTR1AMTR1BNucleotideAdenosineAA1RAA2ARAA2BRAA3RP2YP2RY1P2RY2P2RY4P2RY6P2Y11P2Y12P2Y13P2Y14OtherUnclassifiedUS28PeptideAngiotensinAGTR1AGTR2ApelinAPJBombesinNMBRGRPRBRS3BradykininBKRB1BKRB2CholecystokininCCKARGASRComplement peptideC3ARC5AR1C5AR2EndothelinEDNRAEDNRBFormylpeptideFPR1FPR2FPR3GalaninGALR1GALR2GALR3GhrelinGHSRGonadotrophin-releasing hormoneGNRHRKisspeptinKISSRMelanin-concentrating hormoneMCHR1MCHR2MelanocortinMSHRACTHRMC3RMC4RMC5RMotilinMTLRNeuromedin UNMUR1NMUR2Neuropeptide FF/neuropeptide AFNPFF1NPFF2Neuropeptide SNPSR1Neuropeptide W/neuropeptide BNPBW1NPBW2Neuropeptide YNPY1RNPY2RNPY4RNPY5RNPY6RNeurotensinNTR1NTR2OpioidOPRDOPRKOPRMOPRXOrexinOX1ROX2RPeptide P518QRFPRProlactin-releasing peptidePRLHRProteinase-activatedPAR1PAR2PAR3PAR4Relaxin family peptideRXFP1RXFP2RL3R1RL3R2SomatostatinSSR1SSR2SSR3SSR4SSR5TachykininNK1RNK2RNK3RThyrotropin-releasing hormoneTRFRUrotensinUR2RVasopressin and oxytocinV1ARV1BRV2ROXYRProteinChemerin receptorCML1CML2ChemokineCCR1CCR2CCR3CCR4CCR5CCR6CCR7CCR8CCR9CCR10CXCR1CXCR2CXCR3CXCR4CXCR5CXCR6CX3C1XCR1ACKR1ACKR2ACKR3ACKR4CCRL2Glycoprotein hormoneFSHRLSHRTSHRProkineticinPKR1PKR2SensoryOpsinsOPSDOPN3OPN4OPN5OPSBOPSGOPSROPSXSteroidBile acidGPBAREstrogen (G protein-coupled)GPER1




Class A
Orphans

Class A orphansGPR3GPR4GPR6GPR12GPR15GPR17GPR19GPR20GPR21GPR22GPR25GPR26GPR27GPR31GPR32GPR33GPR34GPR35GPR37G37L1GPR39GPR45MTR1LGPR52GPR61GPR62GPR63PSYROGR1GPR75GPR78GPR82GPR83GPR84GPR85GPR87GPR88GP101GP132GP135GP139GP141GP142GP146GP148GP149GP150GP151GP152GP153GP160GP161GP162GP171GP173GP174GP176GP182GP183LGR4LGR5LGR6MASMAS1LMRGRDMRGREMRGRFMRGRGMRGX1MRGX2MRGX3MRGX4P2RY8P2Y10TAAR2TAAR3TAAR5TAAR6TAA7FTAAR8TAAR9TAAR4

Class B1
(Secretin)

CalcitoninCALCRCALRLCorticotropin-releasingfactorCRFR1CRFR2GlucagonreceptorfamilyGHRHRGIPRGLP1RGLP2RGLRSCTRParathyroidhormonePTH1RPTH2RVIP and PACAPPACRVIPR1VIPR2

Class B2
(Adhesion)

ADGRAAGRA1AGRA2AGRA3ADGRBAGRB1AGRB2AGRB3ADGRCCELR1CELR2CELR3ADGRDAGRD1AGRD2ADGREAGRE1AGRE2AGRE3AGRE4AGRE5ADGRFAGRF1AGRF2AGRF3AGRF4AGRF5ADGRGAGRG1AGRG2AGRG3AGRG4AGRG5AGRG6AGRG7ADGRLAGRL1AGRL2AGRL3AGRL4ADGRVAGRV1



Class C
(Glutamate)

GABA BGABR1GABR2MetabotropicglutamateGRM1GRM2GRM3GRM4GRM5GRM6GRM7GRM8Calcium-sensingCASRClass COrphansGP156GP158GP179RAI3GPC5BGPC5CGPC5DGPC6ATaste 1TS1R1TS1R2TS1R3

Class F
(Frizzled)

FrizzledFZD1FZD2FZD3FZD4FZD5FZD6FZD7FZD8FZD9FZD10SMO

Class T
(Taste 2)

Taste 2TA2R1TA2R3TA2R4TA2R5TA2R7TA2R8TA2R9T2R10T2R13T2R14T2R16T2R19T2R20T2R30T2R31T2R38T2R39T2R40T2R41T2R42T2R43T2R45T2R46T2R50T2R60

References

Selectivity Landscape of 100 Therapeutically Relevant GPCR Profiled by an Effector Translocation-Based BRET Platform.
Avet, C., Mancini, A., Breton, B., Gouill, C. L., Hauser, A. S., Normand, C., Kobayashi, H., Gross, F., Hogue, M., Lukasheva, V., Morissette, S., Fauman, E., Fortin, J.-P., Schann, S., Leroy, X., Gloriam, D. E. & Bouvier, M.
bioRxiv 2020.04.20.052027 (2020). doi: 10.1101/2020.04.20.052027