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ARRESTIN
STRUCTURE
RECEPTOR
OTHER PROTEINS
STRUCTURE LIGAND
ENDOGENOUS LIGAND
REFERENCE
Fam. Arrestin Species Note % of Seq Method
PDB
Refined
structure
Resolution
UniProt
IUPHAR Receptor family Class Species Receptor fusion Antibodies Other Name Type Function Name Type Authors Reference PDB Date
Visual S-arrestin Mouse Fragment 2 X-ray 4PXF 4PXF_refined 2.8 OPSD Rhodopsin Opsins A (Rhodopsin) Bovine - - - B-Octylglucoside pubchem
small-molecule unknown - - Szczepek M, Beyriere F, Hofmann KP, Elgeti M, Kazmin R, Rose A, Bartl FJ, von Stetten D, Heck M, Sommer ME, Hildebrand PW, Scheerer P 10.1038/NCOMMS5801 2014-09-17
Visual S-arrestin Mouse - 86 X-ray 4ZWJ 4ZWJ_refined 3.3 OPSD Rhodopsin Opsins A (Rhodopsin) Human T4-Lysozyme - - Apo (no ligand)
none Apo (no ligand) - - Kang Y, Zhou XE, Gao X, He Y, Liu W, Ishchenko A, Barty A, White TA, Yefanov O, Han GW, Xu Q, de Waal PW, Ke J, Tan MH, Zhang C, Moeller A, West GM, Pascal BD, Van Eps N, Caro LN, Vishnivetskiy SA, Lee RJ, Suino-Powell KM, Gu X, Pal K, Ma J, Zhi X, Boutet S, Williams GJ, Messerschmidt M, Gati C, Zatsepin NA, Wang D, James D, Basu S, Roy-Chowdhury S, Conrad CE, Coe J, Liu H, Lisova S, Kupitz C, Grotjohann I, Fromme R, Jiang Y, Tan M, Yang H, Li J, Wang M, Zheng Z, Li D, Howe N, Zhao Y, Standfuss J, Diederichs K, Dong Y, Potter CS, Carragher B, Caffrey M, Jiang H, Chapman HN, Spence JC, Fromme P, Weierstall U, Ernst OP, Katritch V, Gurevich VV, Griffin PR, Hubbell WL, Stevens RC, Cherezov V, Melcher K, Xu HE 10.1038/NATURE14656 2015-07-29
Visual S-arrestin Mouse - 86 X-ray 5DGY 5DGY_refined 7.7 OPSD Rhodopsin Opsins A (Rhodopsin) Human T4-Lysozyme - - Apo (no ligand)
none Apo (no ligand) - - Zhou XE, Gao X, Barty A, Kang Y, He Y, Liu W, Ishchenko A, White TA, Yefanov O, Han GW, Xu Q, de Waal PW, Suino-Powell KM, Boutet S, Williams GJ, Wang M, Li D, Caffrey M, Chapman HN, Spence JC, Fromme P, Weierstall U, Stevens RC, Cherezov V, Melcher K, Xu HE 10.1038/SDATA.2016.21 2016-03-23
Visual S-arrestin Mouse - 90 X-ray 5W0P 5W0P_refined 3.0 OPSD Rhodopsin Opsins A (Rhodopsin) Human T4-Lysozyme - - Apo (no ligand)
none Apo (no ligand) - - Zhou XE, He Y, de Waal PW, Gao X, Kang Y, Van Eps N, Yin Y, Pal K, Goswami D, White TA, Barty A, Latorraca NR, Chapman HN, Hubbell WL, Dror RO, Stevens RC, Cherezov V, Gurevich VV, Griffin PR, Ernst OP, Melcher K, Xu HE 10.1016/J.CELL.2017.07.002 2017-08-09
Beta Beta-arrestin-1 Rat - 86 cryo-EM 6U1N 6U1N_refined 4.0 ACM2 M2 Acetylcholine (muscarinic) A (Rhodopsin) Human - Fab30 light chain
Fab30 heavy chain
- LY2119620 pubchem gtoplig chembl_ligand
small-molecule Agonist acetylcholine small-molecule Staus DP, Hu H, Robertson MJ, Kleinhenz ALW, Wingler LM, Capel WD, Latorraca NR, Lefkowitz RJ, Skiniotis G 10.1038/S41586-020-1954-0 2020-02-26
Beta Beta-arrestin-1 Human - 84 cryo-EM 6PWC 6PWC_refined 4.9 NTR1 NTS1 Neurotensin A (Rhodopsin) Human - Fab30 heavy chain
Fab30 light chain
- Neurotensin pubchem
peptide Agonist neurotensin, large neurotensin, neuromedin N, large neuromedin N peptide Yin W, Li Z, Jin M, Yin YL, de Waal PW, Pal K, Yin Y, Gao X, He Y, Gao J, Wang X, Zhang Y, Zhou H, Melcher K, Jiang Y, Cong Y, Edward Zhou X, Yu X, Eric Xu H 10.1038/S41422-019-0256-2 2019-12-04
Beta Beta-arrestin-1 Human - 83 cryo-EM 6UP7 6UP7_refined 4.2 NTR1 NTS1 Neurotensin A (Rhodopsin) Human - - - JMV431 gtoplig chembl_ligand pubchem
peptide Agonist neurotensin, large neurotensin, neuromedin N, large neuromedin N peptide Huang W, Masureel M, Qu Q, Janetzko J, Inoue A, Kato HE, Robertson MJ, Nguyen KC, Glenn JS, Skiniotis G, Kobilka BK 10.1038/S41586-020-1953-1 2020-02-26
Beta Beta-arrestin-1 Human - 82 cryo-EM 6TKO 6TKO_refined 3.3 ADRB1 β1 Adrenoceptors A (Rhodopsin) Wild turkey - Fab30 heavy chain
Fab30 light chain
- arformoterol pubchem gtoplig chembl_ligand drugbank drug_central
small-molecule Agonist - - Lee Y, Warne T, Nehme R, Pandey S, Dwivedi-Agnihotri H, Chaturvedi M, Edwards PC, Garcia-Nafria J, Leslie AGW, Shukla AK, Tate CG 10.1038/S41586-020-2419-1 2020-06-17
Beta Beta-arrestin-1 Human - - X-ray 2IV8 - 2.8 - - - - - - - AP-2 complex subunit Beta-1 - - - - - Schmid EM, Ford MG, Burtey A, Praefcke GJ, Peak-Chew SY, Mills IG, Benmerah A, McMahon HT 16903783 2007-06-12
Beta Beta-arrestin-1 Rat - - X-ray 4JQI - 2.6 - - - - - - Fab30 heavy chain
Fab30 light chain
Vasopressin V2 receptor phosphopeptide - - - - - Shukla AK, Manglik A, Kruse AC, Xiao K, Reis RI, Tseng WC, Staus DP, Hilger D, Uysal S, Huang LY, Paduch M, Tripathi-Shukla P, Koide A, Koide S, Weis WI, Kossiakoff AA, Kobilka BK, Lefkowitz RJ 23604254 2013-04-17
Beta Beta-arrestin-1 Rat - - X-ray 6KL7 - 2.8 - - - - - - - - - - - - - Kang H, Yang HS, Ki AY, Ko SB, Kim KW, Shim CY, Kim K, Choi HJ, Chung KY 31948726 2020-01-29
Beta Beta-arrestin-1 Bovine - - X-ray 1G4M - 1.9 - - - - - - - - - - - - - Han M, Gurevich VV, Vishnivetskiy SA, Sigler PB, Schubert C 11566136 2001-10-03
Beta Beta-arrestin-1 Bovine - - X-ray 1G4R - 2.2 - - - - - - - - - - - - - Han M, Gurevich VV, Vishnivetskiy SA, Sigler PB, Schubert C 11566136 2001-10-03
Beta Beta-arrestin-1 Bovine - - X-ray 1JSY - 2.9 - - - - - - - - - - - - - Milano SK, Pace HC, Kim YM, Brenner C, Benovic JL 11876640 2002-03-27
Beta Beta-arrestin-1 Bovine - - X-ray 1ZSH - 2.9 - - - - - - - - - - - - - Milano SK, Kim YM, Stefano FP, Benovic JL, Brenner C 16439357 2006-01-31
Beta Beta-arrestin-1 Bovine - - X-ray 2WTR - 2.9 - - - - - - - - - - - - - - - 2009-09-29
Beta Beta-arrestin-1 Bovine - - X-ray 3GC3 - 2.2 - - - - - - - Clathrin heavy chain 1 - - - - - Kang DS, Kern RC, Puthenveedu MA, von Zastrow M, Williams JC, Benovic JL 19710023 2009-08-25
Beta Beta-arrestin-1 Bovine - - X-ray 3GD1 - 3.5 - - - - - - - Clathrin heavy chain 1
clathrin
- - - - - Kang DS, Kern RC, Puthenveedu MA, von Zastrow M, Williams JC, Benovic JL 19710023 2009-08-25
Beta Beta-arrestin-1 Bovine - - cryo-EM 6NI2 - 4.0 - - - - - - Nanobody 32
Fab30 Heavy Chain
Fab30 Light Chain
Vasopressin V2 receptor - - - - - Nguyen AH, Thomsen ARB, Cahill TJ 3rd, Huang R, Huang LY, Marcink T, Clarke OB, Heissel S, Masoudi A, Ben-Hail D, Samaan F, Dandey VP, Tan YZ, Hong C, Mahoney JP, Triest S, Little J 4th, Chen X, Sunahara R, Steyaert J, Molina H, Yu Z, des Georges A, Lefkowitz RJ 31740855 2019-11-20
Beta Beta-arrestin-1 Bovine - - X-ray 7DF9 - 3.2 - - - - - - Fab30 Light Chain
Fab30 Heavy Chain
Vasopressin V2 receptor phosphopeptide - - - - - He QT, Xiao P, Huang SM, Jia YL, Zhu ZL, Lin JY, Yang F, Tao XN, Zhao RJ, Gao FY, Niu XG, Xiao KH, Wang J, Jin C, Sun JP, Yu X 33888704 2021-07-28
Beta Beta-arrestin-1 Bovine - - X-ray 7DFA - 2.5 - - - - - - Fab30 Heavy Chain
Fab30 Light Chain
VaRpp-4 - - - - - He QT, Xiao P, Huang SM, Jia YL, Zhu ZL, Lin JY, Yang F, Tao XN, Zhao RJ, Gao FY, Niu XG, Xiao KH, Wang J, Jin C, Sun JP, Yu X 33888704 2021-07-28
Beta Beta-arrestin-1 Bovine - - X-ray 7DFB - 3.3 - - - - - - Fab30 Light Chain
Fab30 Heavy Chain
V2Rpp-6-7 - - - - - He QT, Xiao P, Huang SM, Jia YL, Zhu ZL, Lin JY, Yang F, Tao XN, Zhao RJ, Gao FY, Niu XG, Xiao KH, Wang J, Jin C, Sun JP, Yu X 33888704 2021-07-28
Beta Beta-arrestin-1 Bovine - - X-ray 7DFC - 2.5 - - - - - - Fab30 Light Chain
Fab30 Heavy Chain
V2Rpp-3 - - - - - He QT, Xiao P, Huang SM, Jia YL, Zhu ZL, Lin JY, Yang F, Tao XN, Zhao RJ, Gao FY, Niu XG, Xiao KH, Wang J, Jin C, Sun JP, Yu X 33888704 2021-07-28
Beta Beta-arrestin-2 Rat - - X-ray 6K3F - 2.3 - - - - - - - Peptide from Atypical chemokine receptor 3 - - - - - Min K, Yoon HJ, Park JY, Baidya M, Dwivedi-Agnihotri H, Maharana J, Chaturvedi M, Chung KY, Shukla AK, Lee HH 32579945 2020-06-10
Beta Beta-arrestin-2 Bovine - - X-ray 5TV1 - 2.4 - - - - - - - - - - - - - Chen Q, Perry NA, Vishnivetskiy SA, Berndt S, Gilbert NC, Zhuo Y, Singh PK, Tholen J, Ohi MD, Gurevich EV, Brautigam CA, Klug CS, Gurevich VV, Iverson TM 29127291 2017-11-22
Visual Arrestin-C Eastern tiger salamander - - X-ray 1SUJ - 2.4 - - - - - - - - - - - - - Sutton RB, Vishnivetskiy SA, Robert J, Hanson SM, Raman D, Knox BE, Kono M, Navarro J, Gurevich VV 16289201 2005-08-23
Visual S-arrestin Bovine - - X-ray 1AYR - 3.3 - - - - - - - - - - - - - Granzin J, Wilden U, Choe HW, Labahn J, Krafft B, Buldt G 9495348 1998-11-25
Visual S-arrestin Bovine - - X-ray 1CF1 - 2.8 - - - - - - - - - - - - - Hirsch JA, Schubert C, Gurevich VV, Sigler PB 10219246 1999-04-16
Visual S-arrestin Bovine - - X-ray 3UGU - 1.9 - - - - - - - - - - - - - Granzin J, Cousin A, Weirauch M, Schlesinger R, Buldt G, Batra-Safferling R 22306737 2012-02-08
Visual S-arrestin Bovine - - X-ray 3UGX - 2.6 - - - - - - - - - - - - - Granzin J, Cousin A, Weirauch M, Schlesinger R, Buldt G, Batra-Safferling R 22306737 2012-02-08
Visual S-arrestin Bovine - - X-ray 4J2Q - 3.0 - - - - - - - - - - - - - Kim YJ, Hofmann KP, Ernst OP, Scheerer P, Choe HW, Sommer ME 23604253 2013-05-01
Visual S-arrestin Bovine - - X-ray 4ZRG - 2.7 - - - - - - - - - - - - - Granzin J, Stadler A, Cousin A, Schlesinger R, Batra-Safferling R 26510463 2015-11-11
Visual S-arrestin Bovine - - X-ray 7F1W - 3.1 - - - - - - - - - - - - - - - 2021-10-27
Visual S-arrestin Bovine - - X-ray 7F1X - 3.0 - - - - - - - - - - - - - - - 2021-10-27
Visual S-arrestin Bovine - - X-ray 7JSM - 2.5 - - - - - - - - - - - - - Sander CL, Luu J, Kim K, Furkert D, Jang K, Reichenwallner J, Kang M, Lee HJ, Eger BT, Choe HW, Fiedler D, Ernst OP, Kim YJ, Palczewski K, Kiser PD 34678158 2021-10-13
Visual S-arrestin Bovine - - X-ray 7JTB - 2.6 - - - - - - - - - - - - - Sander CL, Luu J, Kim K, Furkert D, Jang K, Reichenwallner J, Kang M, Lee HJ, Eger BT, Choe HW, Fiedler D, Ernst OP, Kim YJ, Palczewski K, Kiser PD 34678158 2021-10-13
Visual S-arrestin Bovine - - X-ray 7JXA - 2.4 - - - - - - - - - - - - - Sander CL, Luu J, Kim K, Furkert D, Jang K, Reichenwallner J, Kang M, Lee HJ, Eger BT, Choe HW, Fiedler D, Ernst OP, Kim YJ, Palczewski K, Kiser PD 34678158 2021-10-13
Visual S-arrestin Bovine - - X-ray 7MOR - 2.8 - - - - - - - - - - - - - Sander CL, Luu J, Kim K, Furkert D, Jang K, Reichenwallner J, Kang M, Lee HJ, Eger BT, Choe HW, Fiedler D, Ernst OP, Kim YJ, Palczewski K, Kiser PD 34678158 2021-10-13
Visual S-arrestin Bovine - - X-ray 7MP0 - 2.6 - - - - - - - - - - - - - Sander CL, Luu J, Kim K, Furkert D, Jang K, Reichenwallner J, Kang M, Lee HJ, Eger BT, Choe HW, Fiedler D, Ernst OP, Kim YJ, Palczewski K, Kiser PD 34678158 2021-10-13
Visual S-arrestin Bovine - - X-ray 7MP1 - 2.7 - - - - - - - - - - - - - Sander CL, Luu J, Kim K, Furkert D, Jang K, Reichenwallner J, Kang M, Lee HJ, Eger BT, Choe HW, Fiedler D, Ernst OP, Kim YJ, Palczewski K, Kiser PD 34678158 2021-10-13
Visual S-arrestin Bovine - - X-ray 7MP2 - 3.0 - - - - - - - - - - - - - Sander CL, Luu J, Kim K, Furkert D, Jang K, Reichenwallner J, Kang M, Lee HJ, Eger BT, Choe HW, Fiedler D, Ernst OP, Kim YJ, Palczewski K, Kiser PD 34678158 2021-10-13
Visual Visual arrestin Longfin inshore squid - - X-ray 6BK9 - 3.0 - - - - - - - - - - - - - Bandyopadhyay A, Van Eps N, Eger BT, Rauscher S, Yedidi RS, Moroni T, West GM, Robinson KA, Griffin PR, Mitchell J, Ernst OP 30120952 2018-09-19