Arrestin Couplings
| Source | Receptor | Ligand | log(Emax/EC50) | pEC50 | Emax | Standard Deviation | |||||||||||||||
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| Group | Biosensor | Cl | Receptor fam. |
Uniprot
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IUPHAR | Ligand name | Phys. / Surr. | ARRB1 |
ARRB2 no GRK |
ARRB2 | ARRB1 |
ARRB2 no GRK |
ARRB2 | ARRB1 |
ARRB2 no GRK |
ARRB2 | ARRB1 |
ARRB2 no GRK |
ARRB2 | ||
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| Bouvier | GEMTA | A | 5-Hydroxytryptamine | 5HT1A | 5-HT1A | 5-hydroxytryptamine | Physiological | 5.3 | 5.1 | 5.5 | 6.5 | 6.6 | 6.6 | 7 | 3 | 8 | 2.1 | 6.6 | 3.5 | Bouvier | |
| Bouvier | GEMTA | A | 5-Hydroxytryptamine | 5HT1B | 5-HT1B | 5-hydroxytryptamine | Physiological | 5.7 | 5.7 | 6.1 | 7.5 | 7.6 | 7.7 | 2 | 1 | 3 | 2.1 | 2.1 | 2.1 | Bouvier | |
| Bouvier | GEMTA | A | 5-Hydroxytryptamine | 5HT1D | 5-HT1D | 5-hydroxytryptamine | Physiological | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0 | 0 | 0 | 0.0 | 0.0 | 0.0 | Bouvier | |
| Bouvier | GEMTA | A | 5-Hydroxytryptamine | 5HT2A | 5-HT2A | 5-hydroxytryptamine | Physiological | 6.3 | 5.9 | 6.6 | 7.0 | 6.7 | 7.0 | 24 | 17 | 34 | 24.8 | 16.9 | 128.5 | Bouvier | |
| Bouvier | GEMTA | A | 5-Hydroxytryptamine | 5HT2B | 5-HT2B | 5-hydroxytryptamine | Physiological | 5.9 | 6.6 | 7.2 | 7.4 | 7.8 | 8.2 | 4 | 6 | 11 | 2.9 | 5.4 | 17.1 | Bouvier | |
| Bouvier | GEMTA | A | 5-Hydroxytryptamine | 5HT2C | 5-HT2C | 5-hydroxytryptamine | Physiological | 7.7 | 7.7 | 7.9 | 8.1 | 8.0 | 8.5 | 36 | 53 | 31 | 28.6 | 69.8 | 23.8 | Bouvier | |
| Bouvier | GEMTA | A | Acetylcholine (muscarinic) | ACM1 | M1 | acetylcholine | Physiological | 4.0 | 0.0 | 4.1 | 5.2 | 0.0 | 5.1 | 7 | 0 | 9 | 26.8 | 0.0 | 18.2 | Bouvier | |
| Bouvier | GEMTA | A | Acetylcholine (muscarinic) | ACM2 | M2 | acetylcholine | Physiological | 5.6 | 7.0 | 7.3 | 5.8 | 7.3 | 7.6 | 57 | 48 | 51 | 115.5 | 152.3 | 103.2 | Bouvier | |
| Bouvier | GEMTA | A | Dopamine | DRD2 | D2 | dopamine | Physiological | 5.5 | 5.7 | 6.1 | 6.8 | 7.1 | 7.2 | 5 | 4 | 9 | 5.5 | 3.8 | 13.6 | Bouvier | |
| Bouvier | GEMTA | A | Acetylcholine (muscarinic) | ACM3 | M3 | acetylcholine | Physiological | 4.1 | 4.4 | 4.9 | 5.4 | 6.4 | 5.9 | 4 | 1 | 10 | 7.6 | 3.7 | 78.9 | Bouvier | |
| Bouvier | GEMTA | A | Acetylcholine (muscarinic) | ACM4 | M4 | acetylcholine | Physiological | 5.2 | 5.9 | 6.5 | 6.1 | 6.5 | 7.0 | 16 | 22 | 31 | 26.7 | 22.1 | 193.8 | Bouvier | |
| Bouvier | GEMTA | A | Adrenoceptors | ADA1A | α1A-adrenoceptor | noradrenaline | Physiological | 0.0 | 0.0 | 4.9 | 0.0 | 0.0 | 7.0 | 0 | 0 | 1 | 0.0 | 0.0 | 1.2 | Bouvier | |
| Bouvier | GEMTA | A | Adrenoceptors | ADA2A | α2A-adrenoceptor | noradrenaline | Physiological | 5.4 | 5.6 | 5.8 | 6.0 | 6.2 | 6.3 | 26 | 22 | 29 | 17.9 | 22.1 | 24.6 | Bouvier | |
| Bouvier | GEMTA | A | Adrenoceptors | ADA2B | α2B-adrenoceptor | noradrenaline | Physiological | 5.4 | 5.6 | 6.0 | 6.7 | 6.9 | 6.8 | 5 | 5 | 16 | 3.4 | 3.9 | 32.5 | Bouvier | |
| Bouvier | GEMTA | A | Adrenoceptors | ADA2C | α2C-adrenoceptor | noradrenaline | Physiological | 4.7 | 4.8 | 6.2 | 6.0 | 6.1 | 7.1 | 6 | 5 | 11 | 4.0 | 4.2 | 9.6 | Bouvier | |
| Bouvier | GEMTA | A | Adrenoceptors | ADRB1 | β1-adrenoceptor | noradrenaline | Physiological | 5.8 | 5.6 | 5.9 | 6.6 | 6.6 | 6.8 | 14 | 11 | 15 | 11.9 | 56.2 | 8.9 | Bouvier | |
| Bouvier | GEMTA | A | Adrenoceptors | ADRB2 | β2-adrenoceptor | noradrenaline | Physiological | 4.3 | 3.5 | 4.9 | 4.9 | 4.4 | 5.3 | 26 | 13 | 37 | 26.8 | 24.4 | 46.8 | Bouvier | |
| Bouvier | GEMTA | A | Dopamine | DRD1 | D1 | dopamine | Physiological | 4.9 | 4.7 | 5.1 | 5.3 | 5.6 | 5.6 | 40 | 15 | 30 | 28.8 | 36.9 | 84.1 | Bouvier | |
| Bouvier | GEMTA | A | Dopamine | DRD5 | D5 | dopamine | Physiological | 6.0 | 5.4 | 6.0 | 6.7 | 6.8 | 6.9 | 19 | 4 | 12 | 11.8 | 7.0 | 26.8 | Bouvier | |
| Bouvier | GEMTA | A | Histamine | HRH1 | H1 | histamine | Physiological | 4.4 | 3.4 | 5.2 | 4.6 | 4.3 | 5.5 | 68 | 13 | 44 | 74.9 | 24.5 | 128.0 | Bouvier | |
| Bouvier | GEMTA | A | Histamine | HRH2 | H2 | histamine | Physiological | 0.0 | 4.0 | 4.5 | 0.0 | 4.8 | 5.2 | 0 | 15 | 18 | 0.0 | 76.8 | 494.5 | Bouvier | |
| Bouvier | GEMTA | A | Angiotensin | AGTR1 | AT1 | angiotensin II | Physiological | 7.6 | 7.5 | 7.8 | 8.8 | 8.6 | 8.8 | 6 | 7 | 10 | 7.9 | 10.5 | 21.1 | Bouvier | |
| Bouvier | GEMTA | A | Apelin | APJ | apelin | [Pyr1]apelin-13 | Physiological | 7.0 | 7.7 | 7.9 | 7.8 | 8.8 | 9.0 | 16 | 8 | 8 | 14.5 | 10.1 | 6.8 | Bouvier | |
| Bouvier | GEMTA | A | Bradykinin | BKRB1 | B1 | kallidin | Physiological | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0 | 0 | 0 | 0.0 | 0.0 | 0.0 | Bouvier | |
| Bouvier | GEMTA | A | Bradykinin | BKRB2 | B2 | kallidin | Physiological | 8.3 | 8.4 | 8.2 | 8.5 | 8.6 | 8.5 | 62 | 58 | 52 | 65.9 | 74.8 | 54.8 | Bouvier | |
| Bouvier | GEMTA | A | Cholecystokinin | CCKAR | CCK1 | CCK-8 | Physiological | 7.7 | 8.0 | 8.5 | 7.9 | 8.3 | 8.7 | 57 | 46 | 66 | 421.6 | 72.1 | 150.5 | Bouvier | |
| Bouvier | GEMTA | A | Complement peptide | C5AR1 | C5a1 | C5a | Physiological | 7.6 | 7.8 | 7.7 | 7.7 | 7.8 | 7.7 | 83 | 100 | 100 | 72.2 | 119.9 | 248.5 | Bouvier | |
| Bouvier | GEMTA | A | Endothelin | EDNRA | ETA | endothelin-1 | Physiological | 8.0 | 7.5 | 8.2 | 8.5 | 8.2 | 8.4 | 30 | 20 | 69 | 29.7 | 26.5 | 83.2 | Bouvier | |
| Bouvier | GEMTA | A | Ghrelin | GHSR | ghrelin | ghrelin | Physiological | 7.9 | 6.6 | 7.4 | 8.8 | 8.2 | 8.5 | 12 | 2 | 7 | 12.9 | 5.3 | 11.8 | Bouvier | |
| Bouvier | GEMTA | A | Gonadotrophin-releasing hormone | GNRHR | GnRH1 | GnRH I | Physiological | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0 | 0 | 0 | 0.0 | 0.0 | 0.0 | Bouvier | |
| Bouvier | GEMTA | A | Melanocortin | MC3R | MC3 | γ-MSH | Physiological | 8.2 | 7.0 | 8.2 | 8.7 | 8.7 | 8.8 | 28 | 2 | 27 | 42.9 | 5.7 | 245.9 | Bouvier | |
| Bouvier | GEMTA | A | Melanocortin | MC4R | MC4 | α-MSH | Physiological | 5.5 | 0.0 | 6.0 | 7.0 | 0.0 | 7.4 | 3 | 0 | 3 | 25.1 | 0.0 | 9.7 | Bouvier | |
| Bouvier | GEMTA | A | Neuropeptide FF/neuropeptide AF | NPFF1 | NPFF1 | RFRP-3 | Physiological | 6.5 | 7.0 | 7.2 | 7.4 | 8.0 | 7.8 | 14 | 11 | 27 | 20.8 | 150.3 | 29.5 | Bouvier | |
| Bouvier | GEMTA | A | Neuropeptide FF/neuropeptide AF | NPFF2 | NPFF2 | neuropeptide FF | Physiological | 0.0 | 0.0 | 6.2 | 0.0 | 0.0 | 8.0 | 0 | 0 | 2 | 0.0 | 0.0 | 2.3 | Bouvier | |
| Bouvier | GEMTA | A | Neuropeptide Y | NPY1R | Y1 | neuropeptide Y | Physiological | 0.0 | 6.4 | 7.1 | 0.0 | 8.5 | 8.8 | 0 | 1 | 2 | 0.0 | 1.1 | 9.7 | Bouvier | |
| Bouvier | GEMTA | A | Neuropeptide Y | NPY5R | Y5 | neuropeptide Y | Physiological | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0 | 0 | 0 | 0.0 | 0.0 | 0.0 | Bouvier | |
| Bouvier | GEMTA | A | Opioid | OPRD | δ | SNC80 | Surrogate | 6.4 | 6.5 | 7.1 | 6.9 | 7.1 | 7.5 | 34 | 26 | 43 | 21.6 | 46.0 | 92.3 | Bouvier | |
| Bouvier | GEMTA | A | Opioid | OPRK | κ | dynorphin A | Physiological | 7.5 | 7.2 | 7.4 | 8.4 | 8.4 | 8.4 | 12 | 7 | 10 | 10.1 | 32.9 | 20.6 | Bouvier | |
| Bouvier | GEMTA | A | Opioid | OPRM | μ | DAMGO | Surrogate | 5.5 | 6.6 | 7.1 | 6.1 | 7.1 | 7.4 | 26 | 34 | 52 | 27.0 | 168.2 | 92.5 | Bouvier | |
| Bouvier | GEMTA | A | Opioid | OPRX | NOP | nociceptin/orphanin FQ | Physiological | 7.3 | 6.9 | 7.7 | 8.6 | 8.2 | 8.7 | 5 | 5 | 10 | 6.5 | 12.0 | 18.3 | Bouvier | |
| Bouvier | GEMTA | A | Orexin | OX2R | OX2 | orexin-A | Physiological | 8.1 | 7.9 | 8.1 | 8.4 | 8.5 | 8.6 | 44 | 29 | 38 | 106.7 | 96.2 | 144.3 | Bouvier | |
| Bouvier | GEMTA | A | Proteinase-activated | PAR1 | PAR1 | TFLLR-NH2 | Physiological | 4.6 | 4.3 | 4.5 | 5.1 | 5.1 | 5.2 | 31 | 15 | 21 | 151.3 | 36.5 | 52.2 | Bouvier | |
| Bouvier | GEMTA | A | Proteinase-activated | PAR2 | PAR2 | PAR2 peptide | Physiological | 4.4 | 4.1 | 4.1 | 4.6 | 4.6 | 4.7 | 54 | 29 | 21 | 3732.9 | 62.3 | 18.6 | Bouvier | |
| Bouvier | GEMTA | A | Somatostatin | SSR2 | SST2 | SRIF-14 | Physiological | 8.4 | 8.8 | 8.8 | 8.4 | 8.8 | 8.9 | 100 | 96 | 80 | 195.7 | 1147.4 | 112.7 | Bouvier | |
| Bouvier | GEMTA | A | Vasopressin and oxytocin | V1AR | V1A | vasopressin | Physiological | 7.5 | 7.2 | 7.4 | 7.8 | 7.7 | 7.8 | 48 | 30 | 41 | 177.4 | 97.9 | 164.6 | Bouvier | |
| Bouvier | GEMTA | A | Vasopressin and oxytocin | V2R | V2 | vasopressin | Physiological | 7.3 | 6.7 | 7.0 | 7.6 | 7.6 | 7.8 | 49 | 12 | 15 | 42.5 | 63.0 | 81.5 | Bouvier | |
| Bouvier | GEMTA | A | Vasopressin and oxytocin | OXYR | OT | oxytocin | Physiological | 7.3 | 6.7 | 7.6 | 8.2 | 8.1 | 8.6 | 12 | 4 | 10 | 12.8 | 8.1 | 27.8 | Bouvier | |
| Bouvier | GEMTA | A | Chemokine | CCR5 | CCR5 | CCL3 | Physiological | 6.9 | 7.7 | 8.0 | 7.6 | 8.2 | 8.3 | 21 | 34 | 52 | 10.1 | 24.9 | 39.5 | Bouvier | |
| Bouvier | GEMTA | A | Chemokine | CCR6 | CCR6 | CCL2 | Physiological | 6.4 | 6.3 | 6.5 | 7.8 | 7.6 | 7.5 | 4 | 5 | 9 | 10.9 | 6.1 | 11.4 | Bouvier | |
| Bouvier | GEMTA | A | Chemokine | CXCR2 | CXCR2 | CXCL8 | Physiological | 7.6 | 8.3 | 7.6 | 8.0 | 8.6 | 8.2 | 43 | 44 | 26 | 54.8 | 57.4 | 27.0 | Bouvier | |
| Bouvier | GEMTA | A | Chemokine | CXCR4 | CXCR4 | CXCL12α | Physiological | 5.1 | 6.4 | 5.9 | 6.4 | 8.4 | 7.3 | 5 | 1 | 4 | 12.8 | 9.6 | 5.2 | Bouvier | |
| Bouvier | GEMTA | A | Chemokine | CXCR5 | CXCR5 | CXCL13 | Physiological | 6.5 | 6.5 | 6.8 | 6.8 | 6.9 | 7.0 | 46 | 45 | 57 | 41.4 | 37.7 | 82.6 | Bouvier | |
| Bouvier | GEMTA | A | Free fatty acid | FFAR2 | FFA2 | propanoic acid | Physiological | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0 | 0 | 0 | 0.0 | 0.0 | 0.0 | Bouvier | |
| Bouvier | GEMTA | A | Free fatty acid | FFAR3 | FFA3 | propanoic acid | Physiological | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0 | 0 | 0 | 0.0 | 0.0 | 0.0 | Bouvier | |
| Bouvier | GEMTA | A | Free fatty acid | FFAR4 | FFA4 | α-linolenic acid | Physiological | 4.8 | 4.3 | 4.5 | 4.9 | 4.7 | 4.9 | 69 | 37 | 44 | 80.3 | 42.6 | 88.3 | Bouvier | |
| Bouvier | GEMTA | A | Leukotriene | LT4R1 | BLT1 | LTB4 | Physiological | 7.6 | 6.7 | 7.7 | 7.7 | 7.0 | 7.9 | 83 | 46 | 64 | 74.8 | 71.4 | 60.6 | Bouvier | |
| Bouvier | GEMTA | A | Leukotriene | LT4R2 | BLT2 | LTB4 | Physiological | 5.9 | 0.0 | 5.4 | 7.7 | 0.0 | 6.9 | 2 | 0 | 3 | 1.1 | 0.0 | 3.3 | Bouvier | |
| Bouvier | GEMTA | A | Leukotriene | CLTR1 | CysLT1 | LTB4 | Physiological | 6.0 | 5.6 | 5.9 | 6.7 | 6.4 | 6.6 | 18 | 14 | 20 | 20.1 | 25.7 | 24.9 | Bouvier | |
| Bouvier | GEMTA | A | Leukotriene | CLTR2 | CysLT2 | LTB4 | Physiological | 2.8 | 5.5 | 6.2 | 2.9 | 6.9 | 7.6 | 93 | 4 | 4 | 196.0 | 8.1 | 18.3 | Bouvier | |
| Bouvier | GEMTA | A | Lysophospholipid (LPA) | LPAR1 | LPA1 | 2-oleoyl-LPA | Physiological | 6.0 | 6.5 | 6.5 | 6.6 | 7.5 | 7.5 | 27 | 10 | 10 | 26.4 | 95.6 | 11.5 | Bouvier | |
| Bouvier | GEMTA | A | Lysophospholipid (LPA) | LPAR2 | LPA2 | 2-oleoyl-LPA | Physiological | 6.2 | 6.2 | 6.7 | 6.6 | 6.8 | 7.1 | 35 | 24 | 41 | 39.3 | 328.7 | 199.4 | Bouvier | |
| Bouvier | GEMTA | A | Lysophospholipid (S1P) | S1PR1 | S1P1 | sphingosine 1-phosphate | Physiological | 6.0 | 6.5 | 6.8 | 6.8 | 7.3 | 7.5 | 16 | 16 | 24 | 77.0 | 179.5 | 55.9 | Bouvier | |
| Bouvier | GEMTA | A | Cannabinoid | CNR1 | CB1 | WIN55212-2 | Surrogate | 4.5 | 0.0 | 5.2 | 5.3 | 0.0 | 6.2 | 17 | 0 | 11 | 17.0 | 0.0 | 9.4 | Bouvier | |
| Bouvier | GEMTA | A | Cannabinoid | CNR2 | CB2 | WIN55212-2 | Surrogate | 7.1 | 7.2 | 7.3 | 8.6 | 8.6 | 8.6 | 3 | 4 | 5 | 5.2 | 10.4 | 6.5 | Bouvier | |
| Bouvier | GEMTA | A | Prostanoid | PE2R1 | EP1 | PGE2 | Physiological | 5.8 | 0.0 | 0.0 | 7.4 | 0.0 | 0.0 | 2 | 0 | 0 | 3.1 | 0.0 | 0.0 | Bouvier | |
| Bouvier | GEMTA | A | Prostanoid | PE2R2 | EP2 | PGE2 | Physiological | 5.9 | 5.1 | 5.6 | 7.3 | 6.5 | 6.9 | 4 | 4 | 4 | 4.1 | 4.9 | 5.1 | Bouvier | |
| Bouvier | GEMTA | A | Prostanoid | PE2R3 | EP3 | PGE2 | Physiological | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0 | 0 | 0 | 0.0 | 0.0 | 0.0 | Bouvier | |
| Bouvier | GEMTA | A | Prostanoid | PE2R4 | EP4 | PGE2 | Physiological | 8.0 | 7.8 | 8.1 | 8.6 | 8.9 | 9.2 | 28 | 8 | 6 | 34.9 | 32.5 | 9.2 | Bouvier | |
| Bouvier | GEMTA | A | Prostanoid | PF2R | FP | PGD2 | Physiological | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0 | 0 | 0 | 0.0 | 0.0 | 0.0 | Bouvier | |
| Bouvier | GEMTA | A | Melatonin | MTR1A | MT1 | melatonin | Physiological | 8.0 | 7.4 | 7.6 | 8.9 | 8.9 | 8.8 | 13 | 3 | 7 | 13.2 | 10.6 | 16.7 | Bouvier | |
| Bouvier | GEMTA | A | Melatonin | MTR1B | MT2 | melatonin | Physiological | 0.0 | 5.6 | 6.4 | 0.0 | 7.8 | 8.6 | 0 | 1 | 1 | 0.0 | 4.8 | 1.5 | Bouvier | |
| Bouvier | GEMTA | A | Adenosine | AA1R | A1 | adenosine | Physiological | 4.9 | 0.0 | 4.8 | 6.5 | 0.0 | 6.3 | 3 | 0 | 3 | 4.2 | 0.0 | 6.9 | Bouvier | |
| Bouvier | GEMTA | A | Adenosine | AA2AR | A2A | adenosine | Physiological | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0 | 0 | 0 | 0.0 | 0.0 | 0.0 | Bouvier | |
| Bouvier | GEMTA | A | Adenosine | AA2BR | A2B | adenosine | Physiological | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0 | 0 | 0 | 0.0 | 0.0 | 0.0 | Bouvier | |
| Bouvier | GEMTA | A | Adenosine | AA3R | A3 | adenosine | Physiological | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0 | 0 | 0 | 0.0 | 0.0 | 0.0 | Bouvier | |
| Bouvier | GEMTA | A | P2Y | P2RY2 | P2Y2 | uridine triphosphate | Physiological | 4.4 | 4.0 | 4.0 | 5.0 | 5.2 | 5.4 | 24 | 6 | 4 | 28.5 | 20.4 | 12.8 | Bouvier | |
| Bouvier | GEMTA | A | Bile acid | GPBAR | GPBA | lithocholic acid | Physiological | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0 | 0 | 0 | 0.0 | 0.0 | 0.0 | Bouvier | |
| Bouvier | GEMTA | A | Hydroxycarboxylic acid | HCAR2 | HCA2 | nicotinic acid | Physiological | 4.9 | 4.6 | 5.5 | 5.9 | 6.1 | 6.3 | 12 | 3 | 14 | 19.6 | 7.2 | 17.0 | Bouvier | |
| Bouvier | GEMTA | A | Hydroxycarboxylic acid | HCAR3 | HCA3 | 3-hydroxyoctanoic acid | Physiological | 2.4 | 2.8 | 2.8 | 3.5 | 3.5 | 3.5 | 8 | 20 | 21 | 5.6 | 28.1 | 41.5 | Bouvier | |
| Bouvier | GEMTA | A | A orphans | GPR4 | GPR4 | pH (proton) | Physiological | 6.1 | 5.8 | 0.0 | 7.0 | 7.7 | 0.0 | 12 | 1 | 0 | 31.0 | 5.9 | 0.0 | Bouvier | |
| Bouvier | GEMTA | A | A orphans | GPR39 | GPR39 | Zn2+ | Physiological | 2.7 | 0.0 | 2.3 | 4.0 | 0.0 | 4.0 | 4 | 0 | 2 | 18.8 | 0.0 | 6.9 | Bouvier | |
| Bouvier | GEMTA | A | A orphans | PSYR | GPR65 | pH (proton) | Physiological | 5.0 | 4.3 | 0.0 | 6.3 | 6.0 | 0.0 | 5 | 2 | 0 | 18.7 | 2.6 | 0.0 | Bouvier | |
| Bouvier | GEMTA | A | A orphans | OGR1 | GPR68 | pH (proton) | Physiological | 4.9 | 4.7 | 4.9 | 6.0 | 6.3 | 6.1 | 7 | 3 | 6 | 6.7 | 5.0 | 9.8 | Bouvier | |
| Bouvier | GEMTA | A | A orphans | GPR84 | GPR84 | undecanoic acid | Physiological | 0.0 | 0.0 | 1.1 | 0.0 | 0.0 | 2.4 | 0 | 0 | 5 | 0.0 | 0.0 | 15.4 | Bouvier | |
| Bouvier | GEMTA | A | A orphans | GP183 | GPR183 | 7α,25-dihydroxycholesterol | Physiological | 7.8 | 8.5 | 8.2 | 8.2 | 8.9 | 8.8 | 35 | 37 | 25 | 103.2 | 57.9 | 24.8 | Bouvier | |
| Bouvier | GEMTA | B1 | Calcitonin | CALCR | CT | Human Calcitonin (hCT) | Physiological | 7.0 | 6.5 | 7.1 | 8.2 | 8.3 | 8.2 | 7 | 2 | 8 | 9.5 | 15.4 | 18.3 | Bouvier | |
| Bouvier | GEMTA | B1 | Corticotropin-releasing factor | CRFR1 | CRF1 | urocortin 2 | Physiological | 6.1 | 6.4 | 6.1 | 6.9 | 7.4 | 6.8 | 18 | 10 | 21 | 29.2 | 38.3 | 221.9 | Bouvier | |
| Bouvier | GEMTA | B1 | Corticotropin-releasing factor | CRFR2 | CRF2 | urocortin 2 | Physiological | 7.9 | 7.8 | 8.0 | 8.0 | 8.1 | 8.2 | 76 | 48 | 63 | 127.7 | 72.1 | 220.6 | Bouvier | |
| Bouvier | GEMTA | B1 | Glucagon | GIPR | GIP | gastric inhibitory polypeptide | Physiological | 6.7 | 5.7 | 7.2 | 8.4 | 7.4 | 8.4 | 2 | 2 | 6 | 2.2 | 9.7 | 19.0 | Bouvier | |
| Bouvier | GEMTA | B1 | Glucagon | GLP1R | GLP-1 | glucagon-like peptide 1-(7-37) | Physiological | 7.8 | 7.6 | 8.1 | 8.1 | 8.3 | 8.5 | 46 | 19 | 41 | 46.0 | 95.7 | 97.5 | Bouvier | |
| Bouvier | GEMTA | B1 | Glucagon | GLP2R | GLP-2 | glucagon-like peptide 2 | Physiological | 7.4 | 8.1 | 8.1 | 8.2 | 8.8 | 8.6 | 16 | 20 | 30 | 13.7 | 18.2 | 76.8 | Bouvier | |
| Bouvier | GEMTA | B1 | Glucagon | GLR | glucagon | glucagon | Physiological | 7.3 | 7.0 | 7.8 | 7.7 | 7.5 | 8.2 | 45 | 33 | 39 | 187.4 | 62.7 | 43.0 | Bouvier | |
| Bouvier | GEMTA | B1 | Parathyroid hormone | PTH1R | PTH1 | teriparatide | Physiological | 8.4 | 8.7 | 8.6 | 8.6 | 8.7 | 8.8 | 64 | 91 | 69 | 69.5 | 217.4 | 135.7 | Bouvier | |
| Bouvier | GEMTA | B1 | VIP and PACAP | VIPR1 | VPAC1 | VIP | Physiological | 8.8 | 8.8 | 8.9 | 9.1 | 9.1 | 9.3 | 49 | 46 | 46 | 113.3 | 331.9 | 252.8 | Bouvier | |
| Bouvier | GEMTA | C | Metabotropic glutamate | GRM2 | mGlu2 | L-glutamic acid | Physiological | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0 | 0 | 0 | 0.0 | 0.0 | 0.0 | Bouvier | |
| Bouvier | GEMTA | C | Metabotropic glutamate | GRM4 | mGlu4 | L-glutamic acid | Physiological | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0 | 0 | 0 | 0.0 | 0.0 | 0.0 | Bouvier | |
| Bouvier | GEMTA | C | Metabotropic glutamate | GRM5 | mGlu5 | L-glutamic acid | Physiological | 3.4 | 0.0 | 0.0 | 5.6 | 0.0 | 0.0 | 1 | 0 | 0 | 1.6 | 0.0 | 0.0 | Bouvier | |
| Bouvier | GEMTA | C | Metabotropic glutamate | GRM6 | mGlu6 | L-glutamic acid | Physiological | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0 | 0 | 0 | 0.0 | 0.0 | 0.0 | Bouvier | |
| Bouvier | GEMTA | C | Metabotropic glutamate | GRM8 | mGlu8 | L-glutamic acid | Physiological | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0.0 | 0 | 0 | 0 | 0.0 | 0.0 | 0.0 | Bouvier | |