Arrestin Couplings



Source Receptor Ligand log(Emax/EC50) pEC50 Emax Standard Deviation
Group Biosensor Cl Receptor fam.
Uniprot
IUPHAR Ligand name Phys. / Surr. ARRB1 ARRB2
no GRK
ARRB2 ARRB1 ARRB2
no GRK
ARRB2 ARRB1 ARRB2
no GRK
ARRB2 ARRB1 ARRB2
no GRK
ARRB2
























Bouvier GEMTA A 5-Hydroxytryptamine 5HT1A 5-HT1A 5-hydroxytryptamine Physiological 5.3 5.1 5.5 6.5 6.6 6.6 7 3 8 2.1 6.6 3.5 Bouvier
Bouvier GEMTA A 5-Hydroxytryptamine 5HT1B 5-HT1B 5-hydroxytryptamine Physiological 5.7 5.7 6.1 7.5 7.6 7.7 2 1 3 2.1 2.1 2.1 Bouvier
Bouvier GEMTA A 5-Hydroxytryptamine 5HT1D 5-HT1D 5-hydroxytryptamine Physiological 0.0 0.0 0.0 0.0 0.0 0.0 0 0 0 0.0 0.0 0.0 Bouvier
Bouvier GEMTA A 5-Hydroxytryptamine 5HT2A 5-HT2A 5-hydroxytryptamine Physiological 6.3 5.9 6.6 7.0 6.7 7.0 24 17 34 24.8 16.9 128.5 Bouvier
Bouvier GEMTA A 5-Hydroxytryptamine 5HT2B 5-HT2B 5-hydroxytryptamine Physiological 5.9 6.6 7.2 7.4 7.8 8.2 4 6 11 2.9 5.4 17.1 Bouvier
Bouvier GEMTA A 5-Hydroxytryptamine 5HT2C 5-HT2C 5-hydroxytryptamine Physiological 7.7 7.7 7.9 8.1 8.0 8.5 36 53 31 28.6 69.8 23.8 Bouvier
Bouvier GEMTA A Acetylcholine (muscarinic) ACM1 M1 acetylcholine Physiological 4.0 0.0 4.1 5.2 0.0 5.1 7 0 9 26.8 0.0 18.2 Bouvier
Bouvier GEMTA A Acetylcholine (muscarinic) ACM2 M2 acetylcholine Physiological 5.6 7.0 7.3 5.8 7.3 7.6 57 48 51 115.5 152.3 103.2 Bouvier
Bouvier GEMTA A Dopamine DRD2 D2 dopamine Physiological 5.5 5.7 6.1 6.8 7.1 7.2 5 4 9 5.5 3.8 13.6 Bouvier
Bouvier GEMTA A Acetylcholine (muscarinic) ACM3 M3 acetylcholine Physiological 4.1 4.4 4.9 5.4 6.4 5.9 4 1 10 7.6 3.7 78.9 Bouvier
Bouvier GEMTA A Acetylcholine (muscarinic) ACM4 M4 acetylcholine Physiological 5.2 5.9 6.5 6.1 6.5 7.0 16 22 31 26.7 22.1 193.8 Bouvier
Bouvier GEMTA A Adrenoceptors ADA1A α1A-adrenoceptor noradrenaline Physiological 0.0 0.0 4.9 0.0 0.0 7.0 0 0 1 0.0 0.0 1.2 Bouvier
Bouvier GEMTA A Adrenoceptors ADA2A α2A-adrenoceptor noradrenaline Physiological 5.4 5.6 5.8 6.0 6.2 6.3 26 22 29 17.9 22.1 24.6 Bouvier
Bouvier GEMTA A Adrenoceptors ADA2B α2B-adrenoceptor noradrenaline Physiological 5.4 5.6 6.0 6.7 6.9 6.8 5 5 16 3.4 3.9 32.5 Bouvier
Bouvier GEMTA A Adrenoceptors ADA2C α2C-adrenoceptor noradrenaline Physiological 4.7 4.8 6.2 6.0 6.1 7.1 6 5 11 4.0 4.2 9.6 Bouvier
Bouvier GEMTA A Adrenoceptors ADRB1 β1-adrenoceptor noradrenaline Physiological 5.8 5.6 5.9 6.6 6.6 6.8 14 11 15 11.9 56.2 8.9 Bouvier
Bouvier GEMTA A Adrenoceptors ADRB2 β2-adrenoceptor noradrenaline Physiological 4.3 3.5 4.9 4.9 4.4 5.3 26 13 37 26.8 24.4 46.8 Bouvier
Bouvier GEMTA A Dopamine DRD1 D1 dopamine Physiological 4.9 4.7 5.1 5.3 5.6 5.6 40 15 30 28.8 36.9 84.1 Bouvier
Bouvier GEMTA A Dopamine DRD5 D5 dopamine Physiological 6.0 5.4 6.0 6.7 6.8 6.9 19 4 12 11.8 7.0 26.8 Bouvier
Bouvier GEMTA A Histamine HRH1 H1 histamine Physiological 4.4 3.4 5.2 4.6 4.3 5.5 68 13 44 74.9 24.5 128.0 Bouvier
Bouvier GEMTA A Histamine HRH2 H2 histamine Physiological 0.0 4.0 4.5 0.0 4.8 5.2 0 15 18 0.0 76.8 494.5 Bouvier
Bouvier GEMTA A Angiotensin AGTR1 AT1 angiotensin II Physiological 7.6 7.5 7.8 8.8 8.6 8.8 6 7 10 7.9 10.5 21.1 Bouvier
Bouvier GEMTA A Apelin APJ apelin [Pyr1]apelin-13 Physiological 7.0 7.7 7.9 7.8 8.8 9.0 16 8 8 14.5 10.1 6.8 Bouvier
Bouvier GEMTA A Bradykinin BKRB1 B1 kallidin Physiological 0.0 0.0 0.0 0.0 0.0 0.0 0 0 0 0.0 0.0 0.0 Bouvier
Bouvier GEMTA A Bradykinin BKRB2 B2 kallidin Physiological 8.3 8.4 8.2 8.5 8.6 8.5 62 58 52 65.9 74.8 54.8 Bouvier
Bouvier GEMTA A Cholecystokinin CCKAR CCK1 CCK-8 Physiological 7.7 8.0 8.5 7.9 8.3 8.7 57 46 66 421.6 72.1 150.5 Bouvier
Bouvier GEMTA A Complement peptide C5AR1 C5a1 C5a Physiological 7.6 7.8 7.7 7.7 7.8 7.7 83 100 100 72.2 119.9 248.5 Bouvier
Bouvier GEMTA A Endothelin EDNRA ETA endothelin-1 Physiological 8.0 7.5 8.2 8.5 8.2 8.4 30 20 69 29.7 26.5 83.2 Bouvier
Bouvier GEMTA A Ghrelin GHSR ghrelin ghrelin Physiological 7.9 6.6 7.4 8.8 8.2 8.5 12 2 7 12.9 5.3 11.8 Bouvier
Bouvier GEMTA A Gonadotrophin-releasing hormone GNRHR GnRH1 GnRH I Physiological 0.0 0.0 0.0 0.0 0.0 0.0 0 0 0 0.0 0.0 0.0 Bouvier
Bouvier GEMTA A Melanocortin MC3R MC3 γ-MSH Physiological 8.2 7.0 8.2 8.7 8.7 8.8 28 2 27 42.9 5.7 245.9 Bouvier
Bouvier GEMTA A Melanocortin MC4R MC4 α-MSH Physiological 5.5 0.0 6.0 7.0 0.0 7.4 3 0 3 25.1 0.0 9.7 Bouvier
Bouvier GEMTA A Neuropeptide FF/neuropeptide AF NPFF1 NPFF1 RFRP-3 Physiological 6.5 7.0 7.2 7.4 8.0 7.8 14 11 27 20.8 150.3 29.5 Bouvier
Bouvier GEMTA A Neuropeptide FF/neuropeptide AF NPFF2 NPFF2 neuropeptide FF Physiological 0.0 0.0 6.2 0.0 0.0 8.0 0 0 2 0.0 0.0 2.3 Bouvier
Bouvier GEMTA A Neuropeptide Y NPY1R Y1 neuropeptide Y Physiological 0.0 6.4 7.1 0.0 8.5 8.8 0 1 2 0.0 1.1 9.7 Bouvier
Bouvier GEMTA A Neuropeptide Y NPY5R Y5 neuropeptide Y Physiological 0.0 0.0 0.0 0.0 0.0 0.0 0 0 0 0.0 0.0 0.0 Bouvier
Bouvier GEMTA A Opioid OPRD δ SNC-80 Surrogate 6.4 6.5 7.1 6.9 7.1 7.5 34 26 43 21.6 46.0 92.3 Bouvier
Bouvier GEMTA A Opioid OPRK κ dynorphin A Physiological 7.5 7.2 7.4 8.4 8.4 8.4 12 7 10 10.1 32.9 20.6 Bouvier
Bouvier GEMTA A Opioid OPRM μ DAMGO Surrogate 5.5 6.6 7.1 6.1 7.1 7.4 26 34 52 27.0 168.2 92.5 Bouvier
Bouvier GEMTA A Opioid OPRX NOP nociceptin/orphanin FQ Physiological 7.3 6.9 7.7 8.6 8.2 8.7 5 5 10 6.5 12.0 18.3 Bouvier
Bouvier GEMTA A Orexin OX2R OX2 orexin-A Physiological 8.1 7.9 8.1 8.4 8.5 8.6 44 29 38 106.7 96.2 144.3 Bouvier
Bouvier GEMTA A Proteinase-activated PAR1 PAR1 PAR1 peptide Physiological 4.6 4.3 4.5 5.1 5.1 5.2 31 15 21 151.3 36.5 52.2 Bouvier
Bouvier GEMTA A Proteinase-activated PAR2 PAR2 PAR2 peptide Physiological 4.4 4.1 4.1 4.6 4.6 4.7 54 29 21 3732.9 62.3 18.6 Bouvier
Bouvier GEMTA A Somatostatin SSR2 SST2 SRIF-14 Physiological 8.4 8.8 8.8 8.4 8.8 8.9 100 96 80 195.7 1147.4 112.7 Bouvier
Bouvier GEMTA A Chemokine CXCR2 CXCR2 CXCL8 Physiological 7.6 8.3 7.6 8.0 8.6 8.2 43 44 26 54.8 57.4 27.0 Bouvier
Bouvier GEMTA A Vasopressin and oxytocin V1AR V1A vasopressin Physiological 7.5 7.2 7.4 7.8 7.7 7.8 48 30 41 177.4 97.9 164.6 Bouvier
Bouvier GEMTA A Vasopressin and oxytocin V2R V2 vasopressin Physiological 7.3 6.7 7.0 7.6 7.6 7.8 49 12 15 42.5 63.0 81.5 Bouvier
Bouvier GEMTA A Vasopressin and oxytocin OXYR OT oxytocin Physiological 7.3 6.7 7.6 8.2 8.1 8.6 12 4 10 12.8 8.1 27.8 Bouvier
Bouvier GEMTA A Chemokine CCR5 CCR5 CCL3 Physiological 6.9 7.7 8.0 7.6 8.2 8.3 21 34 52 10.1 24.9 39.5 Bouvier
Bouvier GEMTA A Chemokine CCR6 CCR6 CCL2 Physiological 6.4 6.3 6.5 7.8 7.6 7.5 4 5 9 10.9 6.1 11.4 Bouvier
Bouvier GEMTA A Chemokine CXCR4 CXCR4 CXCL12α Physiological 5.1 6.4 5.9 6.4 8.4 7.3 5 1 4 12.8 9.6 5.2 Bouvier
Bouvier GEMTA A Chemokine CXCR5 CXCR5 CXCL13 Physiological 6.5 6.5 6.8 6.8 6.9 7.0 46 45 57 41.4 37.7 82.6 Bouvier
Bouvier GEMTA A Free fatty acid FFAR2 FFA2 propanoic acid Physiological 0.0 0.0 0.0 0.0 0.0 0.0 0 0 0 0.0 0.0 0.0 Bouvier
Bouvier GEMTA A Free fatty acid FFAR3 FFA3 propanoic acid Physiological 0.0 0.0 0.0 0.0 0.0 0.0 0 0 0 0.0 0.0 0.0 Bouvier
Bouvier GEMTA A Free fatty acid FFAR4 FFA4 α-linolenic acid Physiological 4.8 4.3 4.5 4.9 4.7 4.9 69 37 44 80.3 42.6 88.3 Bouvier
Bouvier GEMTA A Leukotriene LT4R1 BLT1 LTB4 Physiological 7.6 6.7 7.7 7.7 7.0 7.9 83 46 64 74.8 71.4 60.6 Bouvier
Bouvier GEMTA A Leukotriene LT4R2 BLT2 LTB4 Physiological 5.9 0.0 5.4 7.7 0.0 6.9 2 0 3 1.1 0.0 3.3 Bouvier
Bouvier GEMTA A Leukotriene CLTR1 CysLT1 LTB4 Physiological 6.0 5.6 5.9 6.7 6.4 6.6 18 14 20 20.1 25.7 24.9 Bouvier
Bouvier GEMTA A Leukotriene CLTR2 CysLT2 LTB4 Physiological 2.8 5.5 6.2 2.9 6.9 7.6 93 4 4 196.0 8.1 18.3 Bouvier
Bouvier GEMTA A Lysophospholipid (LPA) LPAR1 LPA1 2-oleoyl-LPA Physiological 6.0 6.5 6.5 6.6 7.5 7.5 27 10 10 26.4 95.6 11.5 Bouvier
Bouvier GEMTA A Lysophospholipid (LPA) LPAR2 LPA2 2-oleoyl-LPA Physiological 6.2 6.2 6.7 6.6 6.8 7.1 35 24 41 39.3 328.7 199.4 Bouvier
Bouvier GEMTA A Lysophospholipid (S1P) S1PR1 S1P1 sphingosine 1-phosphate Physiological 6.0 6.5 6.8 6.8 7.3 7.5 16 16 24 77.0 179.5 55.9 Bouvier
Bouvier GEMTA A Cannabinoid CNR1 CB1 WIN55212-2 Surrogate 4.5 0.0 5.2 5.3 0.0 6.2 17 0 11 17.0 0.0 9.4 Bouvier
Bouvier GEMTA A Cannabinoid CNR2 CB2 WIN55212-2 Surrogate 7.1 7.2 7.3 8.6 8.6 8.6 3 4 5 5.2 10.4 6.5 Bouvier
Bouvier GEMTA A Prostanoid PE2R1 EP1 PGE2 Physiological 5.8 0.0 0.0 7.4 0.0 0.0 2 0 0 3.1 0.0 0.0 Bouvier
Bouvier GEMTA A Prostanoid PE2R2 EP2 PGE2 Physiological 5.9 5.1 5.6 7.3 6.5 6.9 4 4 4 4.1 4.9 5.1 Bouvier
Bouvier GEMTA A Prostanoid PE2R3 EP3 PGE2 Physiological 0.0 0.0 0.0 0.0 0.0 0.0 0 0 0 0.0 0.0 0.0 Bouvier
Bouvier GEMTA A Prostanoid PE2R4 EP4 PGE2 Physiological 8.0 7.8 8.1 8.6 8.9 9.2 28 8 6 34.9 32.5 9.2 Bouvier
Bouvier GEMTA A Prostanoid PF2R FP PGD2 Physiological 0.0 0.0 0.0 0.0 0.0 0.0 0 0 0 0.0 0.0 0.0 Bouvier
Bouvier GEMTA A Melatonin MTR1A MT1 melatonin Physiological 8.0 7.4 7.6 8.9 8.9 8.8 13 3 7 13.2 10.6 16.7 Bouvier
Bouvier GEMTA A Melatonin MTR1B MT2 melatonin Physiological 0.0 5.6 6.4 0.0 7.8 8.6 0 1 1 0.0 4.8 1.5 Bouvier
Bouvier GEMTA A Adenosine AA1R A1 adenosine Physiological 4.9 0.0 4.8 6.5 0.0 6.3 3 0 3 4.2 0.0 6.9 Bouvier
Bouvier GEMTA A Adenosine AA2AR A2A adenosine Physiological 0.0 0.0 0.0 0.0 0.0 0.0 0 0 0 0.0 0.0 0.0 Bouvier
Bouvier GEMTA A Adenosine AA2BR A2B adenosine Physiological 0.0 0.0 0.0 0.0 0.0 0.0 0 0 0 0.0 0.0 0.0 Bouvier
Bouvier GEMTA A Adenosine AA3R A3 adenosine Physiological 0.0 0.0 0.0 0.0 0.0 0.0 0 0 0 0.0 0.0 0.0 Bouvier
Bouvier GEMTA A P2Y P2RY2 P2Y2 uridine triphosphate Physiological 4.4 4.0 4.0 5.0 5.2 5.4 24 6 4 28.5 20.4 12.8 Bouvier
Bouvier GEMTA A Bile acid GPBAR GPBA lithocholic acid Physiological 0.0 0.0 0.0 0.0 0.0 0.0 0 0 0 0.0 0.0 0.0 Bouvier
Bouvier GEMTA A Hydroxycarboxylic acid HCAR2 HCA2 Nicotinic acid Physiological 4.9 4.6 5.5 5.9 6.1 6.3 12 3 14 19.6 7.2 17.0 Bouvier
Bouvier GEMTA A Hydroxycarboxylic acid HCAR3 HCA3 3-hydroxyoctanoic acid Physiological 2.4 2.8 2.8 3.5 3.5 3.5 8 20 21 5.6 28.1 41.5 Bouvier
Bouvier GEMTA A A orphans GPR4 GPR4 pH (proton) Physiological 6.1 5.8 0.0 7.0 7.7 0.0 12 1 0 31.0 5.9 0.0 Bouvier
Bouvier GEMTA A A orphans GPR39 GPR39 Zn2+ Physiological 2.7 0.0 2.3 4.0 0.0 4.0 4 0 2 18.8 0.0 6.9 Bouvier
Bouvier GEMTA A A orphans PSYR GPR65 pH (proton) Physiological 5.0 4.3 0.0 6.3 6.0 0.0 5 2 0 18.7 2.6 0.0 Bouvier
Bouvier GEMTA A A orphans OGR1 GPR68 pH (proton) Physiological 4.9 4.7 4.9 6.0 6.3 6.1 7 3 6 6.7 5.0 9.8 Bouvier
Bouvier GEMTA A A orphans GPR84 GPR84 Undecanoic acid Physiological 0.0 0.0 1.1 0.0 0.0 2.4 0 0 5 0.0 0.0 15.4 Bouvier
Bouvier GEMTA A A orphans GP183 GPR183 7α,25-dihydroxycholesterol Physiological 7.8 8.5 8.2 8.2 8.9 8.8 35 37 25 103.2 57.9 24.8 Bouvier
Bouvier GEMTA B1 Calcitonin CALCR CT calcitonin Physiological 7.0 6.5 7.1 8.2 8.3 8.2 7 2 8 9.5 15.4 18.3 Bouvier
Bouvier GEMTA B1 Corticotropin-releasing factor CRFR1 CRF1 corticotrophin-releasing hormone Physiological 6.1 6.4 6.1 6.9 7.4 6.8 18 10 21 29.2 38.3 221.9 Bouvier
Bouvier GEMTA B1 Corticotropin-releasing factor CRFR2 CRF2 urocortin 2 Physiological 7.9 7.8 8.0 8.0 8.1 8.2 76 48 63 127.7 72.1 220.6 Bouvier
Bouvier GEMTA B1 Glucagon GIPR GIP gastric inhibitory polypeptide Physiological 6.7 5.7 7.2 8.4 7.4 8.4 2 2 6 2.2 9.7 19.0 Bouvier
Bouvier GEMTA B1 Glucagon GLP1R GLP-1 glucagon-like peptide 1-(7-37) Physiological 7.8 7.6 8.1 8.1 8.3 8.5 46 19 41 46.0 95.7 97.5 Bouvier
Bouvier GEMTA B1 Glucagon GLP2R GLP-2 glucagon-like peptide 2 Physiological 7.4 8.1 8.1 8.2 8.8 8.6 16 20 30 13.7 18.2 76.8 Bouvier
Bouvier GEMTA B1 Glucagon GLR glucagon glucagon Physiological 7.3 7.0 7.8 7.7 7.5 8.2 45 33 39 187.4 62.7 43.0 Bouvier
Bouvier GEMTA B1 Parathyroid hormone PTH1R PTH1 Parathyroid Hormone Physiological 8.4 8.7 8.6 8.6 8.7 8.8 64 91 69 69.5 217.4 135.7 Bouvier
Bouvier GEMTA B1 VIP and PACAP VIPR1 VPAC1 VIP Physiological 8.8 8.8 8.9 9.1 9.1 9.3 49 46 46 113.3 331.9 252.8 Bouvier
Bouvier GEMTA C Metabotropic glutamate GRM2 mGlu2 L-glutamic acid Physiological 0.0 0.0 0.0 0.0 0.0 0.0 0 0 0 0.0 0.0 0.0 Bouvier
Bouvier GEMTA C Metabotropic glutamate GRM4 mGlu4 L-glutamic acid Physiological 0.0 0.0 0.0 0.0 0.0 0.0 0 0 0 0.0 0.0 0.0 Bouvier
Bouvier GEMTA C Metabotropic glutamate GRM5 mGlu5 L-glutamic acid Physiological 3.4 0.0 0.0 5.6 0.0 0.0 1 0 0 1.6 0.0 0.0 Bouvier
Bouvier GEMTA C Metabotropic glutamate GRM6 mGlu6 L-glutamic acid Physiological 0.0 0.0 0.0 0.0 0.0 0.0 0 0 0 0.0 0.0 0.0 Bouvier
Bouvier GEMTA C Metabotropic glutamate GRM8 mGlu8 L-glutamic acid Physiological 0.0 0.0 0.0 0.0 0.0 0.0 0 0 0 0.0 0.0 0.0 Bouvier