mGlu3 receptor - Beta-arrestin-1

GPCR CLASS (FAMILY)

Class C (Glutamate)

GPCR SPECIES

Homo sapiens

GPCR PREFERRED CHAIN

B

ARRESTIN (FAMILY)

Beta

ARRESTIN

Beta-arrestin-1

ARRESTIN SPECIES

Human

ARRESTIN CHAIN

C

ARRESTIN COVERAGE

83

PDB CODE

9II2

RESOLUTION

3.7 Å

REFERENCE

10.1038/S41589-025-01858-8

PUBLICATION DATE

March 5, 2025

3D VIEW

NGL is a WebGL based 3D viewer powered by MMTF.

LIGAND INTERACTIONS

30 interactions (Click to see)

LIGANDS

L-glutamic acid - Agonist pubchem gtoplig chembl_ligand drugbank drug_central chembl_ligand pubchem pubchem drugbank

PHYSIOLOGICAL LIGANDS

NAAG, L-glutamic acid



GPCR - Arrestin interface interactions



The biflare plot is a modified version of a flareplot, where lines are drawn between an inner concentric circle (arrestin residues) and an outer concentric circle (GPCR residues) depicting the interface interactions.
Different interaction types are shown with different line types (aromatic - solid, hydrophobic - dashed, ionic - long dashed, polar - dotted, Van der Waals - dash-dot).
The interactive features include filtering on interaction type, segments, residues and backbone or sidechain interactions.


Interaction definitions:

Residue numbering:

GPCR-Arrestin backbone (bb) or sidechain (sc):





Structures

Sequence Color

Arrestin, GPCR
Interaction cut-off: strict (stick), loose (line)

NGL is a WebGL based 3D viewer powered by MMTF.

Interaction
type		 GPCR
Segment
AA
Number		 Generic
number		 Arrestin
segment
AA
Number		 Generic
number
Hydrophobic ICL2 Q 678 - s17s18 K 284 C.s17s18.10
Van-der-waals ICL2 Q 678 - s17s18 K 284 C.s17s18.10
Hydrophobic ICL2 N 675 - S16 P 252 C.S16.06
Polar TM6 E 763 6x31 s15s16 N 245 C.s15s16.04
Ionic ICL2 R 679 - s5s6 E 66 N.s5s6.03
Polar ICL2 R 679 - s5s6 E 66 N.s5s6.03
Hydrophobic ICL2 R 679 - s5s6 E 66 N.s5s6.03
Van-der-waals ICL2 R 679 - s5s6 E 66 N.s5s6.03
Hydrophobic C-term V 835 - s5s6 L 73 N.s5s6.10
Hydrophobic ICL2 V 673 - S16 P 252 C.S16.06
Van-der-waals ICL2 V 673 - S16 P 252 C.S16.06
Hydrophobic ICL2 V 673 - S16 V 251 C.S16.05
Polar C-term A 858 - S1 K 10 N.S1.03
Hydrophobic C-term A 858 - S1 K 10 N.S1.03
Van-der-waals C-term A 858 - S1 K 10 N.S1.03
Polar C-term V 862 - ns1 T 6 N.ns1.14
Van-der-waals C-term V 862 - ns1 T 6 N.ns1.14
Hydrophobic ICL2 V 673 - S16 Y 249 C.S16.03
Van-der-waals ICL2 V 673 - S16 Y 249 C.S16.03
Hydrophobic C-term V 862 - S1 V 8 N.S1.01
Hydrophobic ICL1 P 605 12x48 s5s6 L 73 N.s5s6.10
Hydrophobic C-term P 863 - H1 K 107 N.H1.09
Van-der-waals C-term P 863 - H1 K 107 N.H1.09
Hydrophobic TM6 P 762 6x30 S16 A 247 C.S16.01
Hydrophobic C-term V 862 - H1 L 104 N.H1.06
Hydrophobic TM3 I 669 3x57 S16 A 247 C.S16.01
Hydrophobic ICL2 N 675 - S16 M 255 C.S16.09
Van-der-waals ICL2 N 675 - S16 M 255 C.S16.09
Polar ICL2 N 675 - S15 R 236 C.S15.09
Van-der-waals ICL2 N 675 - S15 R 236 C.S15.09
Polar C-term V 835 - S6 R 76 N.S6.02
Van-der-waals C-term V 835 - S6 R 76 N.S6.02
Hydrophobic TM3 I 669 3x57 s5s6 R 65 N.s5s6.02
Van-der-waals TM3 I 669 3x57 s5s6 R 65 N.s5s6.02
Hydrophobic C-term V 862 - H1 K 107 N.H1.09
Hydrophobic ICL2 R 679 - s17s18 R 285 C.s17s18.11
Van-der-waals ICL2 R 679 - s17s18 R 285 C.s17s18.11
Hydrophobic ICL2 Q 678 - s17s18 E 283 C.s17s18.09
Hydrophobic ICL2 K 681 - s5s6 R 65 N.s5s6.02
Van-der-waals ICL2 K 681 - s5s6 R 65 N.s5s6.02
Hydrophobic C-term Q 855 - s1s2 S 13 N.s1s2.01
Hydrophobic TM3 F 670 3x58 S16 A 247 C.S16.01
Polar C-term T 864 - H1 R 103 N.H1.05
Hydrophobic C-term T 864 - H1 R 103 N.H1.05
Van-der-waals C-term T 864 - H1 R 103 N.H1.05
Hydrophobic C-term V 835 - s15s16 F 244 C.s15s16.03
Van-der-waals C-term V 835 - s15s16 F 244 C.s15s16.03
Van-der-waals TM6 F 765 6x33 s15s16 N 245 C.s15s16.04
Hydrophobic ICL3 C 761 - S16 A 247 C.S16.01
Hydrophobic ICL2 K 681 - s5s6 E 66 N.s5s6.03
Van-der-waals ICL2 K 681 - s5s6 E 66 N.s5s6.03
Hydrophobic C-term Y 861 - ns1 T 6 N.ns1.14
Van-der-waals C-term Y 861 - ns1 T 6 N.ns1.14
Hydrophobic C-term Q 855 - S1 A 12 N.S1.05
Van-der-waals C-term Q 855 - S1 A 12 N.S1.05
Hydrophobic C-term V 835 - S6 F 75 N.S6.01
Van-der-waals C-term V 835 - S6 F 75 N.S6.01
Hydrophobic C-term V 862 - H1 R 103 N.H1.05
Hydrophobic C-term H 837 - S6 K 77 N.S6.03
Van-der-waals C-term H 837 - S6 K 77 N.S6.03
Hydrophobic C-term Q 855 - s1s2 P 14 N.s1s2.02
Van-der-waals C-term Q 855 - s1s2 P 14 N.s1s2.02
Hydrophobic C-term T 836 - S6 R 76 N.S6.02
Van-der-waals C-term T 836 - S6 R 76 N.S6.02
Hydrophobic ICL1 K 608 12x51 s5s6 L 71 N.s5s6.08
Van-der-waals ICL1 K 608 12x51 s5s6 L 71 N.s5s6.08
Ionic TM3 D 671 3x59 S16 K 250 C.S16.04
Polar TM3 D 671 3x59 S16 K 250 C.S16.04
Hydrophobic TM3 D 671 3x59 S16 K 250 C.S16.04
Van-der-waals TM3 D 671 3x59 S16 K 250 C.S16.04
Polar ICL2 A 677 - s17s18 K 284 C.s17s18.10
Hydrophobic TM6 P 762 6x30 s15s16 N 245 C.s15s16.04
Van-der-waals TM6 P 762 6x30 s15s16 N 245 C.s15s16.04
Polar ICL2 V 673 - S16 K 250 C.S16.04
Hydrophobic ICL2 V 673 - S16 K 250 C.S16.04
Van-der-waals ICL2 V 673 - S16 K 250 C.S16.04
Hydrophobic C-term V 835 - s5s6 T 74 N.s5s6.11
Van-der-waals C-term V 835 - s5s6 T 74 N.s5s6.11
Hydrophobic C-term Y 861 - ns1 R 7 N.ns1.15
Polar C-term H 837 - S6 R 76 N.S6.02
Polar C-term Y 861 - H1 K 107 N.H1.09
Van-der-waals C-term Y 861 - H1 K 107 N.H1.09
Hydrophobic C-term Y 861 - ns1 G 5 N.ns1.13
Van-der-waals C-term Y 861 - ns1 G 5 N.ns1.13