ArrestinDb

s1pr3_human

NAME

9W0L

ORGANISM

Human (Homo sapiens)

PROTEIN NAME

s1pr3_human

SOURCE

SWISSPROT

SEQUENCE

Perspective: Wild-type Construct


N-term
M	A	T	A	L	P	P	R	L	Q
10



P	V	R	G	N	E	T	L	R	E
20



H	Y	Q	Y	V	G	K	L	A	G
30



R	L	K	E	A	S	E	G	S	T
40


TM1
L	T	T	V	L	F	L	V	I	C
50



S	F	I	V	L	E	N	L	M	V
60



L	I	A	I	W	K	N	N	K	F
70


ICL1				TM2
H	N	R	M	Y	F	F	I	G	N
80



L	A	L	C	D	L	L	A	G	I
90



A	Y	K	V	N	I	L	M	S	G
100


ECL1						TM3
K	K	T	F	S	L	S	P	T	V
110



W	F	L	R	E	G	S	M	F	V
120



A	L	G	A	S	T	C	S	L	L
130



A	I	A	I	E	R	H	L	T	M
140


		ICL2
I	K	M	R	P	Y	D	A	N	K
150


TM4
R	H	R	V	F	L	L	I	G	M
160



C	W	L	I	A	F	T	L	G	A
170


					ECL2
L	P	I	L	G	W	N	C	L	H
180



N	L	P	D	C	S	T	I	L	P
190


		TM5
L	Y	S	K	K	Y	I	A	F	C
200



I	S	I	F	T	A	I	L	V	T
210



I	V	I	L	Y	A	R	I	Y	F
220



L	V	K	S	S	S	R	K	V	A
230


TM6
N	H	N	N	S	E	R	S	M	A
240



L	L	R	T	V	V	I	V	V	S
250



V	F	I	A	C	W	S	P	L	F
260



I	L	F	L	I	D	V	A	C	R
270


ECL3				TM7
V	Q	A	C	P	I	L	F	K	A
280



Q	W	F	I	V	L	A	V	L	N
290



S	A	M	N	P	V	I	Y	T	L
300


	H8
A	S	K	E	M	R	R	A	F	F
310


				C-term
R	L	V	C	N	C	L	V	R	G
320



R	G	A	R	A	S	P	I	Q	P
330



A	L	D	P	S	R	S	K	S	S
340



S	S	N	N	S	S	H	S	P	K
350



V	K	E	D	L	P	H	T	A	P
360



S	S	C	I	M	D	K	N	A	A
370



L	Q	N	G	I	F	C	N


	N-term
	E	T	L	R	E	H	Y	Q	Y
24



V	G	K	L	A	G	R	L	K	E
34


				TM1
A	S	E	G	S	T	L	T	T	V
44



L	F	L	V	I	C	S	F	I	V
54



L	E	N	L	M	V	L	I	A	I
64


			ICL1				TM2
W	K	N	N	K	F	H	N	R	M
74



Y	F	F	I	G	N	L	A	L	C
84



D	L	L	A	G	I	A	Y	K	V
94


					ECL1
N	I	L	M	S	G	K	K	T	F
104


		TM3
S	L	S	P	T	V	W	F	L	R
114



E	G	S	M	F	V	A	L	G	A
124



S	T	C	S	L	L	A	I	A	I
134



E	R	H	L	T	M	I	K	M	R
144


ICL2					TM4
P	Y	D	A	N	K	R	H	R	V
154



F	L	L	I	G	M	C	W	L	I
164



A	F	T	L	G	A	L	P	I	L
174


	ECL2
G	W	N	C	L	H	N	L	P	D
184



C	S	T	I	L	P	L	Y	S	K
194


TM5
K	Y	I	A	F	C	I	S	I	F
204



T	A	I	L	V	T	I	V	I	L
214

TM6

Y

A

R

I

Y

F

L

V

K

S

N

H

N

N

S

E

R

S

M

224

239



A	L	L	R	T	V	V	I	V	V
249



S	V	F	I	A	C	W	S	P	L
259



F	I	L	F	L	I	D	V	A	C
269


ECL3					TM7
R	V	Q	A	C	P	I	L	F	K
279



A	Q	W	F	I	V	L	A	V	L
289



N	S	A	M	N	P	V	I	Y	T
299


		H8
L	A	S	K	E	M	R	R	A	F
309



F	R	L	V	C	N	C	L	V	R
319


C-term
G

SCHEMATIC

Perspective: Wild-type Construct

N-term

TM1

ICL1

TM2

ECL1

TM3

ICL2

TM4

ECL2

TM5

ICL3

TM6

ECL3

TM7

H8

C-term

N-term

TM1

ICL1

TM2

ECL1

TM3

ICL2

TM4

ECL2

TM5

TM6

ECL3

TM7

H8

C-term

DIAGRAMS

MUTATIONS

Position	Wild-type	Mutated

DELETIONS

from 1 to 15

from 225 to 230

from 321 to 378

MODIFICATIONS

AUXILIARY PROTEINS

EXPRESSION

Expression method	Host cell type	Host cell	Remarks

SOLUBILIZATION

Solvent type	Item	Concentration

Remarks:

PURIFICATION

Purification type	Description

Remarks:

CRYSTALLIZATION

METHOD:

TYPE: ()

PROTEIN CONCENTRATION:

Temperature:

ph : -

Remarks:

Chemical lists

Type	Item	Concentration