PDB
25ST
Resolution
3.0 Å
Released
June 24, 2026
Receptor
TAS2R4
Class
T2
Species
Homo sapiens
Ligand
L-Trp-Trp-Trp
Function
Agonist
Reference
—

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Ligand Amino Acid Generic Number Segment Interaction Type
L-Trp-Trp-Trp F69 2.64x64 TM2 hydrophobic
L-Trp-Trp-Trp R76 ECL1 polar (charge-assisted hydrogen bond)
L-Trp-Trp-Trp Q249 6.55x55 TM6 Van der Waals
L-Trp-Trp-Trp Y250 6.56x56 TM6 hydrophobic
L-Trp-Trp-Trp Y250 6.56x56 TM6 Van der Waals
L-Trp-Trp-Trp M259 7.32x31 TM7 hydrophobic
L-Trp-Trp-Trp M259 7.32x31 TM7 Van der Waals
L-Trp-Trp-Trp K262 7.35x34 TM7 polar (charge-assisted hydrogen bond)

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Snake plot — Download: PNG | SVG
ICL1 R I ICL1ECL1 N T E R ECL1ICL2 N F Q H S V F L L L K R ICL2ECL2 A S P F P E L V T T R N N T S F N I S E G I L S ECL2ICL3 T G F W ICL3ECL3 G M D ECL3N-term M N-term L R L F Y F S A I I A S V I L N F V G I I M N L F I T V V N C K T W V K S H S S S D R I L F S L G I T R F L M L G L F L V N T I Y F V S S S V Y L S A F F V L C F M F L D S S S V W F V T L L N I L Y C V K I T N I S P K I P R L L L A C V L I S A F T T C L Y I T L S Q L V V S L V L S S S L Q F I I N V T S A S L L I H S L R R H I Q K M Q K N A N P Q T E A H V G A M K L M V Y F L I L Y I P Y S V A T L V Q Y L P F Y A M G T K S I C L I F A T L Y S P G H S V L I I I T H P K A K K K K L K T T I L C F
Helix box plot — Download: PNG | SVG L N M I I G V F N L I V S A I I A S F Y 1 F S L G I T R F L M L G L F L V N T I Y 2 L T V F W V S S S D L F M F C L V F F A 3 I P R L L L A C V L I S A F T T C L Y I 4 A S T V N I I F Q L S S S L V L S V V L 5 M V Y F L I L Y I P Y S V A T L V Q Y L 6 V S H G P S Y L T A F I L C I S K T G 7

GPCRdb(A)
GPCRdb(A)
TAS2R4
TM2
2x64 2.64x64 F69
TM6
6x55 6.55x55 Q249
6x56 6.56x56 Y250
TM7
7x31 7.32x31 M259
7x34 7.35x34 K262