PDB
2X72
Resolution
3.0 Å
Released
March 16, 2011
Receptor
Rhodopsin
Class
A
Species
Bos taurus
Ligand
all-trans-retinal
Function
Agonist
Reference
10.1038/NATURE09795

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Ligand Amino Acid Generic Number Segment Interaction Type
all-trans-retinal I189 45.52x52 ECL2 hydrophobic
all-trans-retinal Y191 ECL2 hydrophobic
all-trans-retinal V204 5.39x40 TM5 hydrophobic
all-trans-retinal M207 5.42x43 TM5 hydrophobic
all-trans-retinal F208 5.43x44 TM5 hydrophobic
all-trans-retinal F212 5.47x47 TM5 hydrophobic
all-trans-retinal W265 6.48x48 TM6 hydrophobic
all-trans-retinal Y268 6.51x51 TM6 hydrophobic
all-trans-retinal A269 6.52x52 TM6 hydrophobic
all-trans-retinal A272 6.55x55 TM6 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 K K L R ICL1ECL1 Y F V F ECL1ICL2 P M S N F R F ICL2ECL2 W S R Y I P E G M Q C S C G I D Y Y T P H E E T ECL2ICL3 Q E ICL3ECL3 Q G S D F ECL3N-term M N G T E G P N F Y V P F S N K T G V V R S P F E A P Q Y Y L A N-termC-term C G K N P L G D D E A S T T V S K T E T S Q V A P A C-term E P W Q F S M L A A Y M F L L I M L G F P I N F L T L Y V T V Q H T P L N Y I L L N L A V A D L F M V F G G F T T T L Y T S L H G G P T G C N L E G F F A T L G G E I A L W S L V V L A I E R Y V V V C K G E N H A I M G V A F T W V M A L A C A A P P L V G N N E S F V I Y M F V V H F I I P L I V I F F C Y G Q L V F T V K E A A A Q Q S A T T Q K A E K E V T R M V I I M V I A F L I C W L P Y A G V A F Y I F T H G P I F M T I P A F F A K T S A V Y N P V I Y I M M N K Q M V T F R N C T L C
Helix box plot — Download: PNG | SVG F N I P F G L M I L L F M Y A A L M S F 1 L N L A V A D L F M V G F G F T T T L Y T 2 V V L S W L A I E G G L T A F F G E L N 3 A I M G V A F T W V M A L A C A A P P L 4 Y C F F I V I L P I I F H V V F M Y I V F 5 I I M V I A F L I C W L P Y A G V A F Y 6 V P N Y V A S T K A F F A P I T M F I 7

GPCRdb(A)
GPCRdb(A)
Rhodopsin
ECL2
45x52 45.52x52 I189
TM5
5x40 5.39x40 V204
5x43 5.42x43 M207
5x44 5.43x44 F208
5x47 5.47x47 F212
TM6
6x48 6.48x48 W265
6x51 6.51x51 Y268
6x52 6.52x52 A269
6x55 6.55x55 A272