PDB
2Y00
Resolution
2.5 Å
Released
Jan. 12, 2011
Receptor
β1
Class
A
Species
Meleagris gallopavo
Ligand
DOBUTAMINE
Function
Agonist (partial)
Reference
—

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Ligand Amino Acid Generic Number Segment Interaction Type
DOBUTAMINE L101 2.64x63 TM2 hydrophobic
DOBUTAMINE W117 3.28x28 TM3 aromatic (edge-to-face)
DOBUTAMINE D121 3.32x32 TM3 polar (charge-assisted hydrogen bond)
DOBUTAMINE V122 3.33x33 TM3 Van der Waals
DOBUTAMINE V122 3.33x33 TM3 hydrophobic
DOBUTAMINE V125 3.36x36 TM3 Van der Waals
DOBUTAMINE F201 45.52x52 ECL2 Van der Waals
DOBUTAMINE F201 45.52x52 ECL2 hydrophobic
DOBUTAMINE S211 5.42x43 TM5 polar (hydrogen bond with backbone)
DOBUTAMINE S211 5.42x43 TM5 polar (hydrogen bond)
DOBUTAMINE F306 6.51x51 TM6 Van der Waals
DOBUTAMINE F306 6.51x51 TM6 aromatic (edge-to-face)
DOBUTAMINE F307 6.52x52 TM6 Van der Waals
DOBUTAMINE F307 6.52x52 TM6 aromatic (edge-to-face)
DOBUTAMINE N310 6.55x55 TM6 polar (hydrogen bond)
DOBUTAMINE N310 6.55x55 TM6 Van der Waals
DOBUTAMINE V326 7.36x35 TM7 Van der Waals
DOBUTAMINE V326 7.36x35 TM7 hydrophobic
DOBUTAMINE N329 7.39x38 TM7 Van der Waals
DOBUTAMINE N329 7.39x38 TM7 polar (hydrogen bond)
DOBUTAMINE W330 7.40x39 TM7 Van der Waals
DOBUTAMINE W330 7.40x39 TM7 aromatic (face-to-edge)
DOBUTAMINE Y333 7.43x42 TM7 Van der Waals
DOBUTAMINE Y333 7.43x42 TM7 hydrophobic

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ICL1 Q R L Q ICL1ECL1 T W L W ECL1ICL2 P F R Y Q S L M ICL2ECL2 W W R D E D P Q A L K C Y Q D P G C C D F V T ECL2ICL3 G R F Y G S Q E Q P Q P P P L P Q H Q P I L G N G R A S K ICL3ECL3 R D L V ECL3N-term M G D G W L P P D C G P H N R S G G G G A T A A P T G S R Q V S N-termC-term F P R K A D R R L H A G G Q P A P L P G G F I S T L G S P E H S P G G T W S D C N G G T R G G S E S S L E E R H S K T S R S E S K M E R E K N I L A T T R F Y C T F L G N G D K A V F C T V L R I V K L F E D A T C T C P H T H K L K M K W R F K Q H Q A C-term A E L L S Q Q W E A G M S L L M A L V V L L I V A G N V L V I A A I G R T T L T N L F I T S L A C A D L V M G L L V V P F G A T L V V R G G S F L C E C W T S L D V L C V T A S I E T L C V I A I D R Y L A I T S T R A R A K V I I C T V W A I S A L V S F L P I M M H N R A Y A I A S S I I S F Y I P L L I M I F V Y L R V Y R E A K E Q I R K I D R C E R K T S R V M A M R E H K A L K T L G I I M G V F T L C W L P F F L V N I V N V F N P D W L F V F F N W L G Y A N S A F N P I I Y C R S P D F K R F R K A L L C
Helix box plot — Download: PNG | SVG V N G A V I L L V V L A M L L S M G A E 1 T S L A C A D L V M G L L V V P F G A T L 2 V C L T E I S A T V C L V D L S T W C E 3 A K V I I C T V W A I S A L V S F L P I 4 Y V F I M I L L P I Y F S I I S S A I A Y 5 G I I M G V F T L C W L P F F L V N I V 6 I P N F A S N A Y G L W N F F V F L W 7

GPCRdb(A)
GPCRdb(A)
β1-adrenoceptor
TM2
2x63 2.64x63 L101
TM3
3x28 3.28x28 W117
3x32 3.32x32 D121
3x33 3.33x33 V122
3x36 3.36x36 V125
ECL2
45x52 45.52x52 F201
TM5
5x43 5.42x43 S211
TM6
6x51 6.51x51 F306
6x52 6.52x52 F307
6x55 6.55x55 N310
TM7
7x35 7.36x35 V326
7x38 7.39x38 N329
7x39 7.40x39 W330
7x42 7.43x42 Y333