PDB
5EE7
Resolution
2.5 Å
Released
April 20, 2016
Receptor
glucagon
Class
B1
Species
Homo sapiens
Ligand
MK-0893
Function
Allosteric antagonist
Reference
10.1038/NATURE17414

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Ligand Amino Acid Generic Number Segment Interaction Type
MK-0893 F345 6.36x36 TM6 hydrophobic
MK-0893 R346 6.37x37 TM6 polar (charge-assisted hydrogen bond)
MK-0893 A348 6.39x39 TM6 hydrophobic
MK-0893 A348 6.39x39 TM6 Van der Waals
MK-0893 K349 6.40x40 TM6 Van der Waals
MK-0893 S350 6.41x41 TM6 polar (hydrogen bond)
MK-0893 L352 6.43x43 TM6 hydrophobic
MK-0893 L352 6.43x43 TM6 Van der Waals
MK-0893 T353 6.44x44 TM6 Van der Waals
MK-0893 L399 7.56x56 TM7 Van der Waals
MK-0893 L399 7.56x56 TM7 hydrophobic
MK-0893 L403 ICL4 hydrophobic
MK-0893 L403 ICL4 Van der Waals
MK-0893 N404 8.47x47 H8 polar (hydrogen bond)
MK-0893 N404 8.47x47 H8 Van der Waals
MK-0893 K405 8.48x48 H8 polar (hydrogen bond with backbone)
MK-0893 K405 8.48x48 H8 Van der Waals

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ICL1 S K L H ICL1ECL1 Q K I G D D L S V S T W L S D G ECL1ICL2 A T L P E R ICL2ECL2 N V Q C W T S N D N M G F ECL2ICL3 R Q M H H T ICL3ECL3 E H A Q ECL3N-term M P P C Q P Q R P L L L L L L L L A C Q P Q V P S A Q V M D F L F E K W K L Y G D Q C H H N L S L L P P P T E L V C N R T F D K Y S C W P D T P A N T T A N I S C P W Y L P W H H K V Q H R F V F K R C G P D G Q W V R G P R G Q P W R D A S Q C Q M D G E E I E V N-termC-term T S N H R A S S S P G H G P P S K E L Q F G R G G G S Q D S S A E T P L A G G L P R L A E S P F C-term Q K E V A K M Y S S F Q V M Y T V G Y S L S L G A L L L A L A I L G G L C T R N A I H A N L F A S F V L K A S S V L V I D G L L R T R Y S A V A G C R V A A V F M Q Y G I V A N Y C W L L V E G L Y L H N L L G L S F F S L Y L G I G W G A P M L F V V P W A V V K C L F E W W I L R F P V F L A I L I N F F I F V R I V Q L L V A K L R A D Y K F R L A K S T L T L I P L L G V H E V V F A F V T D G T L R S A K L F F D L F L S S F Q G L L V A V L Y C F L N K E L R R W R L W E E V Q S E R W H R G K V L R N
Helix box plot — Download: PNG | SVG L L A G L S L S Y G V T Y M V Q F S S Y 1 A N L F A S F V L K A S S V L V I D G L 2 V L L W C Y N A V I G Y Q M F V A A V R 3 F F S L Y L G G I W G A P M L F V V P W A 4 F I F F N I L I A L F V P F R L I W W 5 L T L I P L L G V H E V V F A F V T D 6 V A V L L G Q F S S L F L D F F L K A 7

GPCRdb(A)
GPCRdb(B)
glucagon receptor
TM6
6x31 6.36x36 F345
6x32 6.37x37 R346
6x34 6.39x39 A348
6x35 6.40x40 K349
6x36 6.41x41 S350
6x38 6.43x43 L352
6x39 6.44x44 T353
TM7
7x52 7.56x56 L399
H8
8x47 8.47x47 N404
8x48 8.48x48 K405