Structure information

CCR5

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

5UIW

SPECIES

Homo sapiens

RESOLUTION

2.200

PREFERRED CHAIN

A

REFERENCE

10.1016/J.IMMUNI.2017.05.002

PUBLICATION DATE

June 28, 2017

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
5P7-CCL5 S17 N-term Van der Waals
5P7-CCL5 S17 N-term polar (hydrogen bond with backbone)
5P7-CCL5 E18 N-term Van der Waals
5P7-CCL5 P19 N-term hydrophobic
5P7-CCL5 P19 N-term Van der Waals
5P7-CCL5 C20 N-term Van der Waals
5P7-CCL5 C20 N-term polar (hydrogen bond with backbone)
5P7-CCL5 K22 1.24x24 TM1 Van der Waals
5P7-CCL5 K26 1.28x28 TM1 Van der Waals
5P7-CCL5 A29 1.31x31 TM1 hydrophobic
5P7-CCL5 W86 2.60x60 TM2 Van der Waals
5P7-CCL5 W86 2.60x60 TM2 hydrophobic
5P7-CCL5 Y89 2.63x63 TM2 hydrophobic
5P7-CCL5 Y89 2.63x63 TM2 Van der Waals
5P7-CCL5 A90 2.64x64 TM2 Van der Waals
5P7-CCL5 T105 3.29x29 TM3 Van der Waals
5P7-CCL5 Y108 3.32x32 TM3 Van der Waals
5P7-CCL5 Y108 3.32x32 TM3 hydrophobic
5P7-CCL5 F109 3.33x33 TM3 Van der Waals
5P7-CCL5 F109 3.33x33 TM3 hydrophobic
5P7-CCL5 T167 4.64x65 TM4 Van der Waals
5P7-CCL5 Q170 ECL2 Van der Waals
5P7-CCL5 Q170 ECL2 polar (hydrogen bond)
5P7-CCL5 K171 ECL2 polar (charge-assisted hydrogen bond)
5P7-CCL5 E172 ECL2 polar (hydrogen bond with backbone)
5P7-CCL5 E172 ECL2 polar (charge-assisted hydrogen bond)
5P7-CCL5 G173 ECL2 Van der Waals
5P7-CCL5 T177 ECL2 Van der Waals
5P7-CCL5 C178 45.50x50 ECL2 Van der Waals
5P7-CCL5 S179 45.51x51 ECL2 polar (hydrogen bond)
5P7-CCL5 S179 45.51x51 ECL2 polar (hydrogen bond)
5P7-CCL5 S180 45.52x52 ECL2 Van der Waals
5P7-CCL5 S180 45.52x52 ECL2 polar (hydrogen bond with backbone)
5P7-CCL5 H181 ECL2 Van der Waals
5P7-CCL5 F182 ECL2 polar (hydrogen bond with backbone)
5P7-CCL5 F182 ECL2 Van der Waals
5P7-CCL5 Y184 ECL2 Van der Waals
5P7-CCL5 Y184 ECL2 hydrophobic
5P7-CCL5 Y187 5.31x32 TM5 Van der Waals
5P7-CCL5 Y187 5.31x32 TM5 polar (hydrogen bond)
5P7-CCL5 K191 5.35x36 TM5 polar (charge-assisted hydrogen bond)
5P7-CCL5 Q194 5.38x39 TM5 Van der Waals
5P7-CCL5 T195 5.39x40 TM5 Van der Waals
5P7-CCL5 L255 6.55x55 TM6 Van der Waals
5P7-CCL5 N258 6.58x58 TM6 Van der Waals
5P7-CCL5 N258 6.58x58 TM6 polar (hydrogen bond)
5P7-CCL5 Q261 6.61x61 TM6 Van der Waals
5P7-CCL5 N267 ECL3 Van der Waals
5P7-CCL5 N268 7.24x23 TM7 Van der Waals
5P7-CCL5 C269 7.25x24 TM7 hydrophobic
5P7-CCL5 C269 7.25x24 TM7 Van der Waals
5P7-CCL5 S272 7.28x27 TM7 Van der Waals
5P7-CCL5 D276 7.32x31 TM7 polar (charge-assisted hydrogen bond)
5P7-CCL5 M279 7.35x34 TM7 hydrophobic
5P7-CCL5 M279 7.35x34 TM7 Van der Waals
5P7-CCL5 Q280 7.36x35 TM7 Van der Waals
5P7-CCL5 E283 7.39x38 TM7 polar (charge-assisted hydrogen bond)

Ligands

5P7-CCL5

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Residue Diagrams

M N G V F G F I F V L S Y L P P L L R A 1 L N L A I S D L F F L L T V P F W A H Y 2 L I I F F I G S F F G I F Y L G T L L Q 3 G V V T S V I T W V V A V F A S L P G 4 Y C I V M V L L P L V L G L I V I K L T Q 5 F T I M I V Y F L F W A P Y N I V L L L 6 I P N I C C H T M G L T E T V Q M A Q 7
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ICL1 K R L K ICL1ECL1 Q W D F ECL1ICL2 A V F A L K A R ICL2ECL2 R S Q K E G L H Y T C S S H F P Y S ECL2ICL3 R ICL3ECL3 L N ECL3N-term M D Y Q V S S P I Y D I N Y Y T S E P C Q N-termC-term K H I A K R F C K C C S I F Q Q E A P E R A S S V Y T R S T G E Q E I S V G L C-term K I N V K Q I A A R L L P P L Y S L V F I F G F V G N M L V I L I L I N C S M T D I Y L L N L A I S D L F F L L T V P F W A H Y A A A G N T M C Q L L T G L Y F I G F F S G I F F I I L L T I D R Y L A V V H T V T F G V V T S V I T W V V A V F A S L P G I I F T Q Y Q F W K N F Q T L K I V I L G L V L P L L V M V I C Y S G I L K T L L R C N E K K R H R A V R L I F T I M I V Y F L F W A P Y N I V L L L N T F Q E F F G N C S S S N R L D Q A M Q V T E T L G M T H C C I N P I I Y A F V G E K L L V F R N Y F F Q
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Residue Table


GPCRdb(A)
GPCRdb(A)
CCR5
TM1
1x24 1.24x24 K22
1x28 1.28x28 K26
1x31 1.31x31 A29
TM2
2x60 2.60x60 W86
2x63 2.63x63 Y89
2x64 2.64x64 A90
TM3
3x29 3.29x29 T105
3x32 3.32x32 Y108
3x33 3.33x33 F109
TM4
4x65 4.64x65 T167
ECL2
45x50 45.50x50 C178
45x51 45.51x51 S179
45x52 45.52x52 S180
TM5
5x32 5.31x32 Y187
5x36 5.35x36 K191
5x39 5.38x39 Q194
5x40 5.39x40 T195
TM6
6x55 6.55x55 L255
6x58 6.58x58 N258
6x61 6.61x61 Q261
TM7
7x23 7.24x23 N268
7x24 7.25x24 C269
7x27 7.28x27 S272
7x31 7.32x31 D276
7x34 7.35x34 M279
7x35 7.36x35 Q280
7x38 7.39x38 E283