PDB
5VEW
Resolution
2.7 Å
Released
May 24, 2017
Receptor
GLP-1
Class
B1
Species
Homo sapiens
Ligand
Function
PF-06372222
NAM
Reference
10.1038/NATURE22378

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Ligand Amino Acid Generic Number Segment Interaction Type
PF-06372222 V331 5.61x61 TM5 Van der Waals
PF-06372222 V332 5.62x62 TM5 Van der Waals
PF-06372222 L335 5.65x65 TM5 Van der Waals
PF-06372222 F347 6.36x36 TM6 aromatic (edge-to-face)
PF-06372222 R348 6.37x37 TM6 hydrophobic
PF-06372222 R348 6.37x37 TM6 polar (charge-charge)
PF-06372222 K351 6.40x40 TM6 hydrophobic
PF-06372222 S352 6.41x41 TM6 polar (hydrogen bond)
PF-06372222 S352 6.41x41 TM6 polar (hydrogen bond)
PF-06372222 L354 6.43x43 TM6 Van der Waals
PF-06372222 T355 6.44x44 TM6 polar (hydrogen bond)
PF-06372222 T355 6.44x44 TM6 hydrophobic
PF-06372222 M397 7.52x52 TM7 hydrophobic
PF-06372222 L401 7.56x56 TM7 hydrophobic
PF-06372222 V405 7.60x60 TM7 Van der Waals
PF-06372222 N406 8.47x47 H8 polar (hydrogen bond)

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ICL1 R H L H ICL1ECL1 T A A Q Q H Q W D G L L S Y Q D S ECL1ICL2 S V L ICL2ECL2 D E G C W T R N S ECL2ICL3 M ICL3ECL3 D E H A R ECL3N-term M A G A P G P L R L A L L L L G M V G R A G P R P Q G A T V S L W E T V Q K W R E Y R R Q C Q R S L T E D P P P A T D L F C N R T F D E Y A C W P D G E P G S F V N V S C P W Y L P W A S S V P Q G H V Y R F C T A E G L W L Q K D N S S L P W R D L S E C E E S K R G E R S S P N-termC-term S M K P L K C P T S S L S S G A T A G S S M Y T A T C Q A S C S C-term E E Q L L F L Y I I Y T V G Y A L S F S A L V I A S A I L L G F C T R N Y I H L N L F A S F I L R A L S V F I K D A A L K W M Y S L S C R L V F L L M Q Y C V A A N Y Y W L L V E G V Y L Y T L L A F S E Q W I F R L Y V S I G W G V P L L F V V P W G I V K Y L Y E N M N Y W L I I R L P I L F A I G V N F L I F V R V I C I V V S K L K A N L C K T D I K C R L A K S T L T L I P L L G T H E V I F A F V M G T L R F I K L F T E L S F T S F Q G L M V A I L Y C F V N N E F R K W R L I Q R V Q L E S W E R E H L H D S
Helix box plot — Download: PNG | SVG V L A S F S L A Y G V T Y I I Y L F L L 1 L N L F A S F I L R A L S V F I K D A A 2 V L L W Y Y N A A V C Y Q M L L F V L R 3 I F R L Y V S G I W G V P L L F V V P W G 4 F I L F N V G I A F L I P L R I I L W Y N 5 L T L I P L L G T H E V I F A F V M 6 I A V M L G Q F S T F S L E T F L K I 7

GPCRdb(A)
GPCRdb(B)
GLP-1 receptor
TM5
5x65 5.61x61 V331
5x66 5.62x62 V332
5x69 5.65x65 L335
TM6
6x31 6.36x36 C347
6x32 6.37x37 R348
6x35 6.40x40 K351
6x36 6.41x41 S352
6x38 6.43x43 L354
6x39 6.44x44 T355
TM7
7x48 7.52x52 M397
7x52 7.56x56 L401
7x56 7.60x60 V405
H8
8x47 8.47x47 N406