PDB
6FK8
Resolution
2.9 Å
Released
April 4, 2018
Receptor
Rhodopsin
Class
A
Species
Bos taurus
Ligand
RS08
Function
Agonist
Reference
10.1073/PNAS.1718084115

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Ligand Amino Acid Generic Number Segment Interaction Type
RS08 E122 3.37x37 TM3 polar (charge-assisted hydrogen bond)
RS08 L125 3.40x40 TM3 hydrophobic
RS08 L125 3.40x40 TM3 Van der Waals
RS08 Y191 ECL2 hydrophobic
RS08 Y191 ECL2 Van der Waals
RS08 V204 5.39x40 TM5 Van der Waals
RS08 M207 5.42x43 TM5 hydrophobic
RS08 M207 5.42x43 TM5 Van der Waals
RS08 F208 5.43x44 TM5 hydrophobic
RS08 H211 5.46x461 TM5 Van der Waals
RS08 F212 5.47x47 TM5 hydrophobic
RS08 F212 5.47x47 TM5 Van der Waals
RS08 C264 6.47x47 TM6 Van der Waals
RS08 W265 6.48x48 TM6 hydrophobic
RS08 W265 6.48x48 TM6 Van der Waals
RS08 Y268 6.51x51 TM6 Van der Waals
RS08 Y268 6.51x51 TM6 hydrophobic
RS08 A272 6.55x55 TM6 hydrophobic
RS08 M288 ECL3 Van der Waals
RS08 M288 ECL3 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 K K L R ICL1ECL1 Y F V F ECL1ICL2 P M S N F R F ICL2ECL2 W S R Y I P E G M Q C S C G I D Y Y T P H E E T ECL2ICL3 Q E ICL3ECL3 Q G S D F ECL3N-term M N G T E G P N F Y V P F S N K T G V V R S P F E A P Q Y Y L A N-termC-term C G K N P L G D D E A S T T V S K T E T S Q V A P A C-term E P W Q F S M L A A Y M F L L I M L G F P I N F L T L Y V T V Q H T P L N Y I L L N L A V A D L F M V F G G F T T T L Y T S L H G G P T G C N L E G F F A T L G G E I A L W S L V V L A I E R Y V V V C K G E N H A I M G V A F T W V M A L A C A A P P L V G N N E S F V I Y M F V V H F I I P L I V I F F C Y G Q L V F T V K E A A A Q Q S A T T Q K A E K E V T R M V I I M V I A F L I C W L P Y A G V A F Y I F T H G P I F M T I P A F F A K T S A V Y N P V I Y I M M N K Q M V T F R N C T L C
Helix box plot — Download: PNG | SVG F N I P F G L M I L L F M Y A A L M S F 1 L N L A V A D L F M V G F G F T T T L Y T 2 V V L S W L A I E G G L T A F F G E L N 3 A I M G V A F T W V M A L A C A A P P L 4 Y C F F I V I L P I I F H V V F M Y I V F 5 I I M V I A F L I C W L P Y A G V A F Y 6 V P N Y V A S T K A F F A P I T M F I 7

GPCRdb(A)
GPCRdb(A)
Rhodopsin
TM3
3x37 3.37x37 E122
3x40 3.40x40 L125
TM5
5x40 5.39x40 V204
5x43 5.42x43 M207
5x44 5.43x44 F208
5x461 5.46x461 H211
5x47 5.47x47 F212
TM6
6x47 6.47x47 C264
6x48 6.48x48 W265
6x51 6.51x51 Y268
6x55 6.55x55 A272