PDB
6FKC
Resolution
2.5 Å
Released
April 4, 2018
Receptor
Rhodopsin
Class
A
Species
Bos taurus
Ligand
RS15
Function
Agonist
Reference
10.1073/PNAS.1718084115

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Ligand Amino Acid Generic Number Segment Interaction Type
RS15 L125 3.40x40 TM3 hydrophobic
RS15 Y191 ECL2 hydrophobic
RS15 V204 5.39x40 TM5 hydrophobic
RS15 M207 5.42x43 TM5 hydrophobic
RS15 F208 5.43x44 TM5 aromatic (edge-to-face)
RS15 F212 5.47x47 TM5 aromatic (edge-to-face)
RS15 W265 6.48x48 TM6 hydrophobic
RS15 Y268 6.51x51 TM6 hydrophobic
RS15 A272 6.55x55 TM6 hydrophobic
RS15 I275 6.58x58 TM6 hydrophobic
RS15 M288 ECL3 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 K K L R ICL1ECL1 Y F V F ECL1ICL2 P M S N F R F ICL2ECL2 W S R Y I P E G M Q C S C G I D Y Y T P H E E T ECL2ICL3 Q E ICL3ECL3 Q G S D F ECL3N-term M N G T E G P N F Y V P F S N K T G V V R S P F E A P Q Y Y L A N-termC-term C G K N P L G D D E A S T T V S K T E T S Q V A P A C-term E P W Q F S M L A A Y M F L L I M L G F P I N F L T L Y V T V Q H T P L N Y I L L N L A V A D L F M V F G G F T T T L Y T S L H G G P T G C N L E G F F A T L G G E I A L W S L V V L A I E R Y V V V C K G E N H A I M G V A F T W V M A L A C A A P P L V G N N E S F V I Y M F V V H F I I P L I V I F F C Y G Q L V F T V K E A A A Q Q S A T T Q K A E K E V T R M V I I M V I A F L I C W L P Y A G V A F Y I F T H G P I F M T I P A F F A K T S A V Y N P V I Y I M M N K Q M V T F R N C T L C
Helix box plot — Download: PNG | SVG F N I P F G L M I L L F M Y A A L M S F 1 L N L A V A D L F M V G F G F T T T L Y T 2 V V L S W L A I E G G L T A F F G E L N 3 A I M G V A F T W V M A L A C A A P P L 4 Y C F F I V I L P I I F H V V F M Y I V F 5 I I M V I A F L I C W L P Y A G V A F Y 6 V P N Y V A S T K A F F A P I T M F I 7

GPCRdb(A)
GPCRdb(A)
Rhodopsin
TM3
3x40 3.40x40 L125
TM5
5x40 5.39x40 V204
5x43 5.42x43 M207
5x44 5.43x44 F208
5x47 5.47x47 F212
TM6
6x48 6.48x48 W265
6x51 6.51x51 Y268
6x55 6.55x55 A272
6x58 6.58x58 I275