PDB
6N51
Resolution
4.0 Å
Released
Jan. 23, 2019
Receptor
mGlu5
Class
C
Species
Homo sapiens
Ligands
Nanobody 43
quisqualate
Function
PAM
Agonist
Reference
10.1038/S41586-019-0881-4
Nanobody 43 quisqualate

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Ligand Amino Acid Generic Number Segment Interaction Type
Nanobody 43 R25 N-term Van der Waals
quisqualate Y64 N-term aromatic (edge-to-face)
quisqualate Y64 N-term polar (hydrogen bond)
quisqualate Y64 N-term polar (hydrogen bond)
quisqualate W100 N-term aromatic (edge-to-face)
quisqualate W100 N-term Van der Waals
quisqualate S152 N-term Van der Waals
quisqualate S173 N-term polar (hydrogen bond with backbone)
quisqualate S173 N-term Van der Waals
quisqualate T175 N-term polar (hydrogen bond)
quisqualate T175 N-term Van der Waals
quisqualate Y223 N-term Van der Waals
quisqualate Y223 N-term hydrophobic
quisqualate E279 N-term Van der Waals
quisqualate G280 N-term polar (hydrogen bond with backbone)
quisqualate G280 N-term Van der Waals
quisqualate D305 N-term Van der Waals
quisqualate G306 N-term polar (hydrogen bond with backbone)
quisqualate G306 N-term Van der Waals
Nanobody 43 H350 N-term Van der Waals
Nanobody 43 H350 N-term polar (hydrogen bond)
Nanobody 43 R351 N-term Van der Waals
Nanobody 43 N352 N-term Van der Waals
Nanobody 43 P353 N-term Van der Waals
Nanobody 43 E368 N-term polar (hydrogen bond with backbone)
Nanobody 43 E368 N-term Van der Waals
Nanobody 43 G369 N-term Van der Waals
Nanobody 43 G369 N-term polar (hydrogen bond with backbone)
Nanobody 43 F370 N-term Van der Waals
Nanobody 43 P371 N-term polar (hydrogen bond with backbone)
Nanobody 43 P371 N-term Van der Waals
Nanobody 43 Q372 N-term Van der Waals
Nanobody 43 Q372 N-term polar (hydrogen bond)
Nanobody 43 E373 N-term Van der Waals
Nanobody 43 N374 N-term Van der Waals
quisqualate K396 N-term Van der Waals

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

Snake plot — Download: PNG | SVG
ICL1 T R D P V V K S S ICL1ECL1 A K P ECL1ICL2 A G S K K K I C T K K P R F M ICL2ECL2 P P D I M H D Y P S I R E V Y L I C N T ECL2ICL3 R N V P A N F N ICL3ECL3 N ECL3N-term M V L L L I L S V L L L K E D V R G S A Q S S E R R V V A H M P G D I I I G A L F S V H H Q P T V D K V H E R K C G A V R E Q Y G I Q R V E A M L H T L E R I N S D P T L L P N I T L G C E I R D S C W H S A V A L E Q S I E F I R D S L I S S E E E E G L V R C V D G S S S S F R S K K P I V G V I G P G S S S V A I Q V Q N L L Q L F N I P Q I A Y S A T S M D L S D K T L F K Y F M R V V P S D A Q Q A R A M V D I V K R Y N W T Y V S A V H T E G N Y G E S G M E A F K D M S A K E G I C I A H S Y K I Y S N A G E Q S F D K L L K K L T S H L P K A R V V A C F C E G M T V R G L L M A M R R L G L A G E F L L L G S D G W A D R Y D V T D G Y Q R E A V G G I T I K L Q S P D V K W F D D Y Y L K L R P E T N H R N P W F Q E F W Q H R F Q C R L E G F P Q E N S K Y N K T C N S S L T L K T H H V Q D S K M G F V I N A I Y S M A Y G L H N M Q M S L C P G Y A G L C D A M K P I D G R K L L E S L M K T N F T G V S G D T I L F D E N G D S P G R Y E I M N F K E M G K D Y F D Y I N V G S W D N G E L K M D D D E V W S K K S N I I R S V C S E P C E K G Q I K V I R K G E V S C C W T C T P C K E N E Y V F D E Y T C K A C Q L G S W P T D D L T G C D L I P V Q Y L R W G D N-termC-term T V V R M H V G D G K S S S A A S R S S S L V N L W K R R G S S G E T L R Y K D R R L A Q H K S E I E C F T P K G S M G N G G R A T M S S S N G K S V T W A Q N E K S S R G Q H L W Q R L S I H I N K K E N P N Q T A V I K P F P K S T E S R G L G A G A G A G G S A G G V G A T G G A G C A G A G P G G P E S P D A G P K A L Y D V A E A E E H F P A P A R P R S P S P I S T L S H R A G S A S R T D D D V P S L H S E P V A R S S S S Q G S L M E Q I S S V V T R F T A N I S E L N S M M L S T A A P S P G V G A P L C S S Y L I P K E I Q L P T T M T T F A E I Q P L P A I E V T G G A Q P A A G A Q A A G D A A R E S P A A G P E A A A A K P D L E E L V A L T P P S P F R D S V D S G S T T P N S P V S E S A L C I P S S P K Y D T L I I R D Y T Q S S S S L C-term P E P I A A V V F A C L G L L A T L F V T V V F I I Y S R E L C Y I I L A G I C L G Y L C T F C L I K Q I Y C Y L Q R I G I G L S P A M S Y S A L V T K T N R I A R I L S A C A Q L V I A F I L I C I Q L G I I V A L F I M E T N L G V V T P L G Y N G L L I L S C T F Y A F K T E A K Y I A F T M Y T T C I I W L A F V P I Y F G S Y K I I T M C F S V S L S A T V A L G C M F V P K V Y I I L A K P E R A F T N V R S T S
Helix box plot — Download: PNG | SVG L T A L L G L C A F V V A A I P E P 1 Y I I L A G I C L G Y L C T F C L I 2 T V L A S Y S M A P S L G I G I R Q L Y 3 Q L V I A F I L I C I Q L G I I V A L F 4 A Y F T C S L I L L G N Y G L P T V V G 5 A F T M Y T T C I I W L A F V P I Y F G 6 G L A V T A S L S V S F C M T I I K Y 7

GPCRdb(A)
GPCRdb(C)
mGlu5 receptor