Structure information

CT receptor

PROTEIN CLASS

Class B1 (Secretin)

PDB CODE

6NIY

SPECIES

Homo sapiens

RESOLUTION

3.340

PREFERRED CHAIN

R

REFERENCE

10.1021/ACSPTSCI.8B00056

PUBLICATION DATE

Jan. 23, 2019

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
calcitonin (salmon synthetic) L142 1.33x33 TM1 hydrophobic
calcitonin (salmon synthetic) A145 1.36x36 TM1 hydrophobic
calcitonin (salmon synthetic) L148 1.39x39 TM1 hydrophobic
calcitonin (salmon synthetic) Y149 1.40x40 TM1 hydrophobic
calcitonin (salmon synthetic) I198 2.64x64 TM2 hydrophobic
calcitonin (salmon synthetic) L291 45.52x52 ECL2 hydrophobic
calcitonin (salmon synthetic) V293 ECL2 Van der Waals
calcitonin (salmon synthetic) V293 ECL2 polar (hydrogen bond with backbone)
calcitonin (salmon synthetic) E294 ECL2 polar (charge-assisted hydrogen bond)
calcitonin (salmon synthetic) T295 ECL2 polar (hydrogen bond with backbone)
calcitonin (salmon synthetic) T295 ECL2 Van der Waals
calcitonin (salmon synthetic) L298 5.36x37 TM5 Van der Waals
calcitonin (salmon synthetic) L298 5.36x37 TM5 hydrophobic
calcitonin (salmon synthetic) Y299 5.37x38 TM5 polar (hydrogen bond)
calcitonin (salmon synthetic) H302 5.40x40 TM5 polar (hydrogen bond)
calcitonin (salmon synthetic) F356 6.53x53 TM6 Van der Waals
calcitonin (salmon synthetic) F359 6.56x56 TM6 polar (hydrogen bond with backbone)
calcitonin (salmon synthetic) F359 6.56x56 TM6 Van der Waals
calcitonin (salmon synthetic) P360 ECL3 polar (hydrogen bond with backbone)
calcitonin (salmon synthetic) P360 ECL3 Van der Waals
calcitonin (salmon synthetic) W361 ECL3 polar (hydrogen bond)
calcitonin (salmon synthetic) W361 ECL3 Van der Waals
calcitonin (salmon synthetic) R362 ECL3 Van der Waals
calcitonin (salmon synthetic) Y372 7.38x37 TM7 polar (hydrogen bond)
calcitonin (salmon synthetic) Y372 7.38x37 TM7 Van der Waals
calcitonin (salmon synthetic) H377 7.43x42 TM7 Van der Waals
calcitonin (salmon synthetic) I380 7.46x45 TM7 Van der Waals

Ligands

calcitonin (salmon synthetic)

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Residue Diagrams

V L T F I S L S H G V I A L Y Y L V Y A 1 K N M F L T Y I L N S M I I I I H L V E 2 C L M W F Y N C A M M Y Q H F F H L I K 3 R L R W Y Y L G L W G F P L V P T T I H A 4 L F F F N V V L A A M V P G H I I Y L 5 M I L V P L L G I Q F V V F P W 6 T A V F F G Q F H I L S H M V Y D Y I 7
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ICL1 R S L G ICL1ECL1 V P N G E L V R R D ECL1ICL2 A V F T E K Q ICL2ECL2 N D N C W L S V E T H L ECL2ICL3 E ICL3ECL3 R P S ECL3N-term M R F T F T S R C L A L F L L L N H P T P I L P A F S N Q T Y P T I E P K P F L Y V V G R K K M M D A Q Y K C Y D R M Q Q L P A Y Q G E G P Y C N R T W D G W L C W D D T P A G V L S Y Q F C P D Y F P D F D P S E K V T K Y C D E K G V W F K H P E N N R T W S N Y N-termC-term P S N R S A R A A A A A A E A G D I P I Y I C H Q E L R N E P A N N Q G E E S A E I I P L N I I E Q E S S A C-term T M C N A F T P E K L K N A Y V L Y Y L A I V G H S L S I F T L V I S L G I F V F F C Q R V T L H K N M F L T Y I L N S M I I I I H L V E V P V S C K I L H F F H Q Y M M A C N Y F W M L C E G I Y L H T L I V V R L R W Y Y L L G W G F P L V P T T I H A I T R A V Y F L Y I I H G P V M A A L V V N F F F L L N I V R V L V T K M R E T H A E S H M Y L K A V K A T M I L V P L L G I Q F V V F P W N K M L G K I Y D Y V M H S L I H F Q G F F V A T I Y C F C N N E V K R F K I R W G V Q T T Q W A Q Q W N Q R R
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Residue Table


GPCRdb(A)
GPCRdb(B)
CT receptor
TM1
1x29 1.33x33 L142
1x32 1.36x36 A145
1x35 1.39x39 L148
1x36 1.40x40 Y149
TM2
2x57 2.64x64 I198
ECL2
45x52 45.52x52 L291
TM5
5x41 5.36x37 L298
5x42 5.37x38 Y299
5x44 5.40x40 H302
TM6
6x48 6.53x53 F356
6x51 6.56x56 F359
TM7
7x33 7.38x37 Y372
7x38 7.43x42 H377
7x41 7.46x45 I380