Structure information

δ receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

6PT3

SPECIES

Homo sapiens

RESOLUTION

3.300

PREFERRED CHAIN

A

REFERENCE

10.1126/SCIADV.AAX9115

PUBLICATION DATE

Dec. 11, 2019

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
DPI-287 A98 2.53x53 TM2 hydrophobic
DPI-287 D128 3.32x32 TM3 polar (charge-assisted hydrogen bond)
DPI-287 Y129 3.33x33 TM3 hydrophobic
DPI-287 Y129 3.33x33 TM3 Van der Waals
DPI-287 S131 3.35x35 TM3 Van der Waals
DPI-287 M132 3.36x36 TM3 Van der Waals
DPI-287 M132 3.36x36 TM3 hydrophobic
DPI-287 V217 5.42x43 TM5 Van der Waals
DPI-287 W274 6.48x48 TM6 Van der Waals
DPI-287 W274 6.48x48 TM6 hydrophobic
DPI-287 I277 6.51x51 TM6 hydrophobic
DPI-287 I277 6.51x51 TM6 Van der Waals
DPI-287 H278 6.52x52 TM6 aromatic (face-to-edge)
DPI-287 H278 6.52x52 TM6 Van der Waals
DPI-287 F280 6.54x54 TM6 hydrophobic
DPI-287 F280 6.54x54 TM6 Van der Waals
DPI-287 V281 6.55x55 TM6 Van der Waals
DPI-287 V281 6.55x55 TM6 hydrophobic
DPI-287 W284 6.58x58 TM6 hydrophobic
DPI-287 W284 6.58x58 TM6 Van der Waals
DPI-287 L300 7.35x34 TM7 Van der Waals
DPI-287 L300 7.35x34 TM7 hydrophobic
DPI-287 I304 7.39x38 TM7 hydrophobic
DPI-287 I304 7.39x38 TM7 Van der Waals
DPI-287 G307 7.42x41 TM7 Van der Waals
DPI-287 Y308 7.43x42 TM7 aromatic (face-to-face)
DPI-287 Y308 7.43x42 TM7 Van der Waals
DPI-287 S311 7.46x46 TM7 Van der Waals

Ligands

DPI-287

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Residue Diagrams

V N G L L G V A C V A S Y L A T I A I A 1 F N L A L A D A L A T S T L P F Q S A K 2 M T L T F I S T F M N Y Y D I S L V A K 3 A K L I N I C I W V L A S G V G V P I M 4 Y C V T I I L I P V V F A F L F V C I K T 5 L V V V G A F V V C W A P I H I F V I V 6 V P N L S S N A Y G L A I C L H L A A 7
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ICL1 T K M K ICL1ECL1 T W P F ECL1ICL2 P V K A L D F R ICL2ECL2 V T R P R D G A V V C M L Q F P S ECL2ICL3 R L L S G ICL3ECL3 D I D R R ECL3N-term M E P A P S A G A E L Q P P L F A N A S D A Y P S A C P S A G A N A S G P P N-termC-term P C G R P D P S S F S R A R E A T A R E R V T A C T P S D G P G G G A A A C-term G A R S A S S L A L A I A I T A L Y S A V C A V G L L G N V L V M F G I V R Y T A T N I Y I F N L A L A D A L A T S T L P F Q S A K Y L M E G E L L C K A V L S I D Y Y N M F T S I F T L T M M S V D R Y I A V C H T P A K A K L I N I C I W V L A S G V G V P I M V M A P S W Y W D T V T K I C V F L F A F V V P I L I I T V C Y G L M L L R L R S V S K E K D R S L R R I T R M V L V V V G A F V V C W A P I H I F V I V W T L V D P L V V A A L H L C I A L G Y A N S S L N P V L Y A F L D E N F R Q F K R C L C R K
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Residue Table


GPCRdb(A)
GPCRdb(A)
δ receptor
TM2
2x53 2.53x53 A98
TM3
3x32 3.32x32 D128
3x33 3.33x33 Y129
3x35 3.35x35 N131
3x36 3.36x36 M132
TM5
5x43 5.42x43 V217
TM6
6x48 6.48x48 W274
6x51 6.51x51 I277
6x52 6.52x52 H278
6x54 6.54x54 F280
6x55 6.55x55 V281
6x58 6.58x58 W284
TM7
7x34 7.35x34 L300
7x38 7.39x38 I304
7x41 7.42x41 G307
7x42 7.43x42 Y308
7x46 7.46x46 S311