PDB
7BB6
Resolution
4.2 Å
Released
June 2, 2021
Receptor
V2
Class
A
Species
Homo sapiens
Ligand
vasopressin (Human)
Function
Agonist
Reference
10.1126/SCIADV.ABG5628

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Ligand Amino Acid Generic Number Segment Interaction Type
vasopressin (Human) M123 3.36x36 TM3 hydrophobic
vasopressin (Human) W193 45.51x51 ECL2 hydrophobic
vasopressin (Human) A194 45.52x52 ECL2 polar (hydrogen bond with backbone)
vasopressin (Human) A194 45.52x52 ECL2 Van der Waals
vasopressin (Human) Q291 6.55x55 TM6 Van der Waals
vasopressin (Human) E303 ECL3 Van der Waals
vasopressin (Human) F307 7.35x34 TM7 hydrophobic
vasopressin (Human) F307 7.35x34 TM7 Van der Waals
vasopressin (Human) M311 7.39x38 TM7 polar (hydrogen bond with backbone)
vasopressin (Human) M311 7.39x38 TM7 Van der Waals
vasopressin (Human) A314 7.42x41 TM7 Van der Waals
vasopressin (Human) S315 7.43x42 TM7 polar (hydrogen bond)

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Snake plot — Download: PNG | SVG
ICL1 H W ICL1ECL1 R F R G ECL1ICL2 P M L A Y R H G ICL2ECL2 A Q R N V E G G S G V T D C W A C F A E P ECL2ICL3 P G G R R R G R R T G S P G E G ICL3ECL3 P E A P L E ECL3N-term M L M A S T T S A V P G H P S L P S L P S N S S Q E R P L D T R N-termC-term R T P P S L G P Q D E S C T T A S S S L A K D T S S C-term D P L L A R A E L A L L S I V F V A V A L S N G L V L A A L A R R G R R G A P I H V F I G H L C L A D L A V A L F Q V L P Q L A W K A T D P D A L C R A V K Y L Q M V G M Y A S S Y M I L A M T L D R H R A I C R S G A H W N R P V L V A W A F S L L L S L P Q L F I F W G R R T Y V T W I A L M V F V A P T L G I A A C Q V L I F R E I H A S L V P G P S E R A H V S A A V A K T V R M T L V I V V V Y V L C W A P F F L V Q L W A A W D G A P F V L L M L L A S L N S C T N P W I Y A S F S S S L R S A R G V S S E L L C C
Helix box plot — Download: PNG | SVG G N S L A V A V F V I S L L A L E A R A 1 G H L C L A D L A V A F L Q V L P Q L A W 2 A L I M Y S S A Y M G V M Q L Y K V A R 3 W N R P V L V A W A F S L L L S L P Q 4 Q C A A I G L T P A V F V M L A I W T V Y 5 L V I V V V Y V L C W A P F F L V Q L W 6 W P N T C S N L S A L L M L L V F P A 7

GPCRdb(A)
GPCRdb(A)
V2 receptor
TM3
3x36 3.36x36 M123
ECL2
45x51 45.51x51 W193
45x52 45.52x52 A194
TM6
6x55 6.55x55 Q291
TM7
7x34 7.35x34 F307
7x38 7.39x38 M311
7x41 7.42x41 A314
7x42 7.43x42 S315