PDB
7BB7
Resolution
4.4 Å
Released
June 2, 2021
Receptor
V2
Class
A
Species
Homo sapiens
Ligand
vasopressin (Human)
Function
Agonist
Reference
10.1126/SCIADV.ABG5628

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Ligand Amino Acid Generic Number Segment Interaction Type
vasopressin (Human) R32 N-term polar (charge-assisted hydrogen bond)
vasopressin (Human) D33 1.28x28 TM1 polar (charge-assisted hydrogen bond)
vasopressin (Human) Q96 2.61x60 TM2 Van der Waals
vasopressin (Human) Q119 3.32x32 TM3 Van der Waals
vasopressin (Human) Q119 3.32x32 TM3 polar (hydrogen bond)
vasopressin (Human) M120 3.33x33 TM3 hydrophobic
vasopressin (Human) M120 3.33x33 TM3 Van der Waals
vasopressin (Human) M123 3.36x36 TM3 hydrophobic
vasopressin (Human) M123 3.36x36 TM3 Van der Waals
vasopressin (Human) Y124 3.37x37 TM3 Van der Waals
vasopressin (Human) F178 4.64x65 TM4 Van der Waals
vasopressin (Human) F178 4.64x65 TM4 hydrophobic
vasopressin (Human) W193 45.51x51 ECL2 hydrophobic
vasopressin (Human) W193 45.51x51 ECL2 Van der Waals
vasopressin (Human) A194 45.52x52 ECL2 Van der Waals
vasopressin (Human) A194 45.52x52 ECL2 hydrophobic
vasopressin (Human) F307 7.35x34 TM7 hydrophobic
vasopressin (Human) F307 7.35x34 TM7 Van der Waals
vasopressin (Human) M311 7.39x38 TM7 hydrophobic
vasopressin (Human) M311 7.39x38 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 H W ICL1ECL1 R F R G ECL1ICL2 P M L A Y R H G ICL2ECL2 A Q R N V E G G S G V T D C W A C F A E P ECL2ICL3 P G G R R R G R R T G S P G E G ICL3ECL3 P E A P L E ECL3N-term M L M A S T T S A V P G H P S L P S L P S N S S Q E R P L D T R N-termC-term R T P P S L G P Q D E S C T T A S S S L A K D T S S C-term D P L L A R A E L A L L S I V F V A V A L S N G L V L A A L A R R G R R G A P I H V F I G H L C L A D L A V A L F Q V L P Q L A W K A T D P D A L C R A V K Y L Q M V G M Y A S S Y M I L A M T L D R H R A I C R S G A H W N R P V L V A W A F S L L L S L P Q L F I F W G R R T Y V T W I A L M V F V A P T L G I A A C Q V L I F R E I H A S L V P G P S E R A H V S A A V A K T V R M T L V I V V V Y V L C W A P F F L V Q L W A A W D G A P F V L L M L L A S L N S C T N P W I Y A S F S S S L R S A R G V S S E L L C C
Helix box plot — Download: PNG | SVG G N S L A V A V F V I S L L A L E A R A 1 G H L C L A D L A V A F L Q V L P Q L A W 2 A L I M Y S S A Y M G V M Q L Y K V A R 3 W N R P V L V A W A F S L L L S L P Q 4 Q C A A I G L T P A V F V M L A I W T V Y 5 L V I V V V Y V L C W A P F F L V Q L W 6 W P N T C S N L S A L L M L L V F P A 7

GPCRdb(A)
GPCRdb(A)
V2 receptor
TM1
1x28 1.28x28 D33
TM2
2x60 2.61x60 Q96
TM3
3x32 3.32x32 Q119
3x33 3.33x33 M120
3x36 3.36x36 M123
3x37 3.37x37 Y124
TM4
4x65 4.64x65 F178
ECL2
45x51 45.51x51 W193
45x52 45.52x52 A194
TM7
7x34 7.35x34 F307
7x38 7.39x38 M311