PDB
7EJK
Resolution
3.4 Å
Released
April 13, 2022
Receptor
α2A
Class
A
Species
Homo sapiens
Ligand
oxymetazoline
Function
Agonist
Reference
10.1126/SCIADV.ABJ5347

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Ligand Amino Acid Generic Number Segment Interaction Type
oxymetazoline D128 3.32x32 TM3 polar (charge-assisted hydrogen bond)
oxymetazoline V129 3.33x33 TM3 hydrophobic
oxymetazoline V129 3.33x33 TM3 Van der Waals
oxymetazoline C132 3.36x36 TM3 Van der Waals
oxymetazoline C132 3.36x36 TM3 hydrophobic
oxymetazoline S215 5.42x43 TM5 Van der Waals
oxymetazoline F405 6.51x51 TM6 aromatic (edge-to-face)
oxymetazoline F405 6.51x51 TM6 Van der Waals
oxymetazoline F427 7.39x38 TM7 hydrophobic
oxymetazoline F427 7.39x38 TM7 Van der Waals
oxymetazoline Y431 7.43x42 TM7 hydrophobic
oxymetazoline Y431 7.43x42 TM7 Van der Waals

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ICL1 R A L K ICL1ECL1 Y W Y F ECL1ICL2 A I E Y N L K R ICL2ECL2 S I E K K G G G G G P Q P A E P R C E I N D ECL2ICL3 R G P D A V A A P P G G T E R R P N G L G P E R S A G P G G A E A E P L P T Q L N G A P G E P A P A G P R D T D A L D L E E S S S S D H A E R P P G P R R P E R G P R G K G K A R A S Q V K P G D S L P R R G P G A T G I G T P A A G P G E E R V G A A K A S R W ICL3ECL3 C S V ECL3N-term M F R Q E Q P L A E G S F A P M G S L Q P D A G N A S W N G T E A P G G G A R A T P Y S L N-termC-term G D R K R I V C-term Q V T L T L V C L A G L L M L L T V F G N V L V I I A V F T S A P Q N L F L V S L A S A D I L V A T L V I P F S L A N E V M G G K A W C E I Y L A L D V L F C T S S I V H L C A I S L D R Y W S I T Q T P R R I K A I I I T V W V I S A V I S F P P L I Q K W Y V I S S C I G S F F A P C L I M I L V Y V R I Y Q I A K R R T R V P P S R R G R Q N R E K R F T F V L A V V I G V F V V C W F P F F F T Y T L T A V G P R T L F K F F F W F G Y C N S S L N P V I Y T I F N H D F K K F R R A I L C R
Helix box plot — Download: PNG | SVG V N G F V T L L M L L G A L C V L T L T 1 V S L A S A D I L V A L T V I P F S L A N 2 A C L H V I S S T C F L V D L A L Y I E 3 I K A I I I T V W V I S A V I S F P P L 4 Y V L I M I L C P A F F S G I C S S I V Y 5 A V V I G V F V V C W F P F F F T Y T L 6 V P N L S S N C Y G F W F F F K F L T 7

GPCRdb(A)
GPCRdb(A)
α2A-adrenoceptor
TM3
3x32 3.32x32 D128
3x33 3.33x33 V129
3x36 3.36x36 C132
TM5
5x43 5.42x43 S215
TM6
6x51 6.51x51 F405
TM7
7x38 7.39x38 F427
7x42 7.43x42 Y431