PDB
7EWR
Resolution
4.7 Å
Released
Dec. 1, 2021
Receptor
MGLYR
Class
C
Species
Homo sapiens
Ligand
Regulator of G-protein signaling 7
Function
Allosteric antagonist
Reference
10.1038/S41467-021-27147-1

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Ligand Amino Acid Generic Number Segment Interaction Type
Regulator of G-protein signaling 7 F510 3.58x58 TM3 hydrophobic
Regulator of G-protein signaling 7 L511 3.59x59 TM3 polar (hydrogen bond)
Regulator of G-protein signaling 7 Y598 5.59x59 TM5 Van der Waals
Regulator of G-protein signaling 7 A599 5.60x60 TM5 hydrophobic
Regulator of G-protein signaling 7 A599 5.60x60 TM5 Van der Waals
Regulator of G-protein signaling 7 R601 ICL3 Van der Waals
Regulator of G-protein signaling 7 T602 ICL3 polar (hydrogen bond)
Regulator of G-protein signaling 7 T602 ICL3 polar (hydrogen bond)
Regulator of G-protein signaling 7 T602 ICL3 polar (hydrogen bond)
Regulator of G-protein signaling 7 V603 ICL3 Van der Waals
Regulator of G-protein signaling 7 P604 ICL3 polar (hydrogen bond)
Regulator of G-protein signaling 7 W704 C-term hydrophobic
Regulator of G-protein signaling 7 W704 C-term Van der Waals
Regulator of G-protein signaling 7 E706 C-term Van der Waals
Regulator of G-protein signaling 7 Q724 C-term Van der Waals
Regulator of G-protein signaling 7 I727 C-term polar (hydrogen bond with backbone)
Regulator of G-protein signaling 7 I727 C-term Van der Waals
Regulator of G-protein signaling 7 K731 C-term Van der Waals

NGL is a WebGL based 3D viewer powered by MMTF.

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ICL1 A R K K S I R A S ICL1ECL1 F E P S T ECL1ICL2 R I P Y M ICL2ECL2 E K Q I S L I G Q G K T S D H L I F N M C L I ECL2ICL3 R T V P S A F ICL3ECL3 A S R L ECL3N-term M G A M A Y P L L L C L L L A Q L G L G A V G A S R D P Q G R P D S P R E R T P K G K P H A Q Q P G R A S A S D S S A P W S R S T D G T I L A Q K L A E E V P M D V A S Y L Y T G D S H Q L K R A N C S G R Y E L A G L P G K W P A L A S A H P S L H R A L D T L T H A T N F L N V M L Q S N K S R E Q N L Q D D L D W Y Q A L V W S L L E G E P S I S R A A I T F S T D S L S A P A P Q V F L Q A T R E E S R I L L Q D L S S S A P H L A N A T L E T E W F H G L R R K W R P H L H R R G P N Q G P R G L G H S W R R K D G L G G D K S H F K W S P P Y L E C E N G S Y K P G W L V T L S S A I Y G L Q P N L V P E F R G V M K V D I N L Q K V D I D Q C S S D G W F S G T H K C H L N N S E C M P I K G L G F V L G A Y E C I C K A G F Y H P G V L P V N N F R R R G P D Q H I S G S T K D V S E E A Y V C L P C R E G C P F C A D D S P C F V Q E N-termC-term E L D M G R S G S Y L N S S I N S A W S E H S L D P E D I R D E L K K L Y A Q L E I Y K R K K M I T N N P H L Q K K R C S K K G L G R S I M R R I T E I P E T V S R Q C S K E D K E G A D H G T A K G T A L I R K N P P E S S G N T G K S K E E T L K N R V F S L K K S H S T Y D H V R D Q T E E S S S L P T E S Q E E E T T E N S T L E S L S G K K L T Q K L K E D S E A E S T E S V P L V C K S A S A H N L S S E K K T G H P R T S M L Q K S L S V I A S A K E K T L G L A G K T Q T A G V E E R T K S Q K P L P K D K E T N R N H S N S D N T E T K D P A P Q N S N P A E E P R K P Q K S G I M K Q Q R V N P T T A N S D L N P G T T Q M K D N F D I G E V C P W E V Y D L T P G P V P S E S K V Q K H V S I V A S E M E K N P T F S L K E K S H H K P K A A E V C Q Q S N Q K R I D K A E V C L W E S Q G Q S I L E D E K L L I S K T P V L P E R A K E E N G G Q P R A A N V C A G Q S E E L P P K A V A S K T E N E N L N Q I G H Q E K K T S S S E E N V R G S Y N S S N N F Q Q P L T S R A E V C P W E F E T P A Q P N A G R S V A L P A S S A L S A N K I A G P R K E E I W D S F K V C-term D K Y L R L A I I S F Q A L C M L L D F V S M L V V Y H F G L I L L E T I L F G S L L L Y F P V V I L Y F R C I L L R W A R L L G F A T V Y G T V T L K L H R V L K V F L S R T A Q T G G R V M R M L A V I L L V V F W F L I G W T S S V C Q N L D R W D Y M T A V A E F L F L L W G V Y L C Y A V H E P R Y M A V A V H N E L I I S A I F H T I R F V L Q S D W M L M L Y F A H T H L T V T V T I G L L L I P K F S H S S N N P R D E A Y D I A T E D
Helix box plot — Download: PNG | SVG F D L L M C L A Q F S I I A L R L Y K D 1 E T I L F G S L L L Y F P V V I L Y 2 L T V T G Y V T A F G L L R A W R L L I 3 V M R M L A V I L L V V F W F L I G W T 4 C L Y V G W L L F L F E A V A T M Y D W 5 A V A V H N E L I I S A I F H T I R F V 6 G I T V T V T L H T H A F Y L M L M W D 7

GPCRdb(A)
GPCRdb(C)
MGLYR
TM3
3x54 3.58x58 F510
3x55 3.59x59 L511
TM5
5x59 5.59x59 Y598
5x60 5.60x60 A599