Structure information

MC4 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7F54

SPECIES

Homo sapiens

RESOLUTION

3.000

PREFERRED CHAIN

R

REFERENCE

10.1038/S41422-021-00552-3

PUBLICATION DATE

Nov. 3, 2021

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
afamelanotide E100 2.60x60 TM2 polar (charge-assisted hydrogen bond)
afamelanotide I104 2.64x64 TM2 hydrophobic
afamelanotide I104 2.64x64 TM2 Van der Waals
afamelanotide D122 3.25x25 TM3 Van der Waals
afamelanotide D126 3.29x29 TM3 polar (charge-assisted hydrogen bond)
afamelanotide I129 3.32x32 TM3 Van der Waals
afamelanotide I129 3.32x32 TM3 hydrophobic
afamelanotide I185 4.61x61 TM4 Van der Waals
afamelanotide I185 4.61x61 TM4 hydrophobic
afamelanotide S188 4.64x64 TM4 polar (hydrogen bond with backbone)
afamelanotide S188 4.64x64 TM4 polar (hydrogen bond)
afamelanotide V193 5.39x39 TM5 Van der Waals
afamelanotide I194 5.40x40 TM5 hydrophobic
afamelanotide I194 5.40x40 TM5 Van der Waals
afamelanotide L197 5.43x43 TM5 Van der Waals
afamelanotide L197 5.43x43 TM5 hydrophobic
afamelanotide F261 6.51x51 TM6 hydrophobic
afamelanotide F261 6.51x51 TM6 Van der Waals
afamelanotide H264 6.54x54 TM6 Van der Waals
afamelanotide H264 6.54x54 TM6 polar (hydrogen bond)
afamelanotide L265 6.55x55 TM6 hydrophobic
afamelanotide L265 6.55x55 TM6 Van der Waals
afamelanotide Y268 6.58x58 TM6 Van der Waals
afamelanotide Y268 6.58x58 TM6 aromatic (face-to-edge)
afamelanotide Y268 6.58x58 TM6 polar (hydrogen bond)
afamelanotide P272 ECL3 Van der Waals
afamelanotide P272 ECL3 hydrophobic
afamelanotide M281 ECL3 Van der Waals
afamelanotide F284 7.35x34 TM7 hydrophobic
afamelanotide F284 7.35x34 TM7 Van der Waals
afamelanotide N285 7.36x35 TM7 Van der Waals
afamelanotide L288 7.39x38 TM7 Van der Waals
afamelanotide L288 7.39x38 TM7 hydrophobic

Ligands

afamelanotide

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Residue Diagrams

I N E L L S I V G L T V F V E P S 1 C S L A V A D M L V S V S N G S E T I V 2 S L L S C I S A L L S S C I V S D I V N 3 V G I I I S C I W A A C T V S G I L F I 4 Y L S A M L A L M T F F M T I L C I I V 5 T I L I G V F V V C W A P F F L H L I F 6 L P D I I S N C M I L I L Y L N F H 7
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ICL1 K N L H ICL1ECL1 N S T D T D A ECL1ICL2 A L Q Y H N I M ICL2ECL2 D ECL2ICL3 P G T G A I R ICL3ECL3 P Q N P Y C V C F M S ECL3N-term M V N S T H R G M H T S L H L W N R S S Y R L H S N A S E S L G K G Y S D G G C Y E Q L F V N-termC-term P L G G L C D L S S R Y C-term S P E V F V T L G V I S L L E N I L V I V A I A K N S P M Y F F I C S L A V A D M L V S V S N G S E T I V I T L L Q S F T V N I D N V I D S V I C S S L L A S I C S L L S I A V D R Y F T I F Y T V K R V G I I I S C I W A A C T V S G I L F I I Y S S S A V I I C L I T M F F T M L A L M A S L Y V H M F L M A R L H I K R I A V L Q G A N M K G A I T L T I L I G V F V V C W A P F F L H L I F Y I S C H F N L Y L I L I M C N S I I D P L I Y A L R S Q E F K E Y L R K T I I C C
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Residue Table


GPCRdb(A)
GPCRdb(A)
MC4 receptor
TM2
2x60 2.60x60 E100
2x64 2.64x64 I104
TM3
3x25 3.25x25 D122
3x29 3.29x29 D126
3x32 3.32x32 I129
TM4
4x61 4.61x61 I185
4x64 4.64x64 S188
TM5
5x39 5.39x39 V193
5x40 5.40x40 I194
5x43 5.43x43 L197
TM6
6x51 6.51x51 F261
6x54 6.54x54 H264
6x55 6.55x55 L265
6x58 6.58x58 Y268
TM7
7x34 7.35x34 F284
7x35 7.36x35 N285
7x38 7.39x38 L288