Structure information

MC4 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7F58

SPECIES

Homo sapiens

RESOLUTION

3.100

PREFERRED CHAIN

R

REFERENCE

10.1038/S41422-021-00552-3

PUBLICATION DATE

Nov. 3, 2021

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
THIQ F45 N-term aromatic (edge-to-face)
THIQ E100 2.60x60 TM2 polar (charge-assisted hydrogen bond)
THIQ T101 2.61x61 TM2 Van der Waals
THIQ I104 2.64x64 TM2 Van der Waals
THIQ I104 2.64x64 TM2 hydrophobic
THIQ D126 3.29x29 TM3 polar (charge-assisted hydrogen bond)
THIQ I129 3.32x32 TM3 Van der Waals
THIQ I129 3.32x32 TM3 hydrophobic
THIQ C130 3.33x33 TM3 hydrophobic
THIQ C130 3.33x33 TM3 Van der Waals
THIQ L133 3.36x36 TM3 hydrophobic
THIQ F184 4.60x60 TM4 Van der Waals
THIQ I185 4.61x61 TM4 hydrophobic
THIQ S188 4.64x64 TM4 Van der Waals
THIQ I194 5.40x40 TM5 Van der Waals
THIQ I194 5.40x40 TM5 hydrophobic
THIQ L197 5.43x43 TM5 Van der Waals
THIQ F261 6.51x51 TM6 Van der Waals
THIQ F261 6.51x51 TM6 hydrophobic
THIQ H264 6.54x54 TM6 polar (hydrogen bond)
THIQ H264 6.54x54 TM6 aromatic (face-to-edge)
THIQ H264 6.54x54 TM6 Van der Waals
THIQ Y268 6.58x58 TM6 Van der Waals
THIQ Y268 6.58x58 TM6 hydrophobic
THIQ F284 7.35x34 TM7 Van der Waals
THIQ F284 7.35x34 TM7 hydrophobic
THIQ N285 7.36x35 TM7 Van der Waals
THIQ L288 7.39x38 TM7 Van der Waals
THIQ L288 7.39x38 TM7 hydrophobic

Ligands

THIQ

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Residue Diagrams

I N E L L S I V G L T V F V E P S 1 C S L A V A D M L V S V S N G S E T I V 2 S L L S C I S A L L S S C I V S D I V N 3 V G I I I S C I W A A C T V S G I L F I 4 Y L S A M L A L M T F F M T I L C I I V 5 T I L I G V F V V C W A P F F L H L I F 6 L P D I I S N C M I L I L Y L N F H 7
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ICL1 K N L H ICL1ECL1 N S T D T D A ECL1ICL2 A L Q Y H N I M ICL2ECL2 D ECL2ICL3 P G T G A I R ICL3ECL3 P Q N P Y C V C F M S ECL3N-term M V N S T H R G M H T S L H L W N R S S Y R L H S N A S E S L G K G Y S D G G C Y E Q L F V N-termC-term P L G G L C D L S S R Y C-term S P E V F V T L G V I S L L E N I L V I V A I A K N S P M Y F F I C S L A V A D M L V S V S N G S E T I V I T L L Q S F T V N I D N V I D S V I C S S L L A S I C S L L S I A V D R Y F T I F Y T V K R V G I I I S C I W A A C T V S G I L F I I Y S S S A V I I C L I T M F F T M L A L M A S L Y V H M F L M A R L H I K R I A V L Q G A N M K G A I T L T I L I G V F V V C W A P F F L H L I F Y I S C H F N L Y L I L I M C N S I I D P L I Y A L R S Q E F K E Y L R K T I I C C
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Residue Table


GPCRdb(A)
GPCRdb(A)
MC4 receptor
TM2
2x60 2.60x60 E100
2x61 2.61x61 T101
2x64 2.64x64 I104
TM3
3x29 3.29x29 D126
3x32 3.32x32 I129
3x33 3.33x33 C130
3x36 3.36x36 L133
TM4
4x60 4.60x60 F184
4x61 4.61x61 I185
4x64 4.64x64 S188
TM5
5x40 5.40x40 I194
5x43 5.43x43 L197
TM6
6x51 6.51x51 F261
6x54 6.54x54 H264
6x58 6.58x58 Y268
TM7
7x34 7.35x34 F284
7x35 7.36x35 N285
7x38 7.39x38 L288