Structure information

GLP-1 receptor

PROTEIN CLASS

Class B1 (Secretin)

PDB CODE

7RTB

SPECIES

Homo sapiens

RESOLUTION

2.140

PREFERRED CHAIN

R

REFERENCE

10.1016/J.BBRC.2021.09.016

PUBLICATION DATE

Oct. 6, 2021

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Peptide-19 T29 N-term polar (hydrogen bond with backbone)
Peptide-19 T29 N-term Van der Waals
Peptide-19 S31 N-term Van der Waals
Peptide-19 S31 N-term polar (hydrogen bond with backbone)
Peptide-19 L32 N-term Van der Waals
Peptide-19 E68 N-term Van der Waals
Peptide-19 Y69 N-term Van der Waals
Peptide-19 Y69 N-term hydrophobic
Peptide-19 E138 1.33x33 TM1 Van der Waals
Peptide-19 L141 1.36x36 TM1 Van der Waals
Peptide-19 L144 1.39x39 TM1 hydrophobic
Peptide-19 L144 1.39x39 TM1 Van der Waals
Peptide-19 Y145 1.40x40 TM1 Van der Waals
Peptide-19 Y145 1.40x40 TM1 aromatic (face-to-face)
Peptide-19 Y148 1.43x43 TM1 polar (hydrogen bond)
Peptide-19 Y148 1.43x43 TM1 Van der Waals
Peptide-19 R190 2.60x60 TM2 Van der Waals
Peptide-19 K197 2.67x67 TM2 polar (charge-assisted hydrogen bond)
Peptide-19 L201 2.71x71 TM2 Van der Waals
Peptide-19 L201 2.71x71 TM2 hydrophobic
Peptide-19 K202 2.72x72 TM2 polar (charge-assisted hydrogen bond)
Peptide-19 Y205 2.75x75 TM2 hydrophobic
Peptide-19 Y205 2.75x75 TM2 Van der Waals
Peptide-19 R310 5.40x40 TM5 polar (charge-assisted hydrogen bond)
Peptide-19 I313 5.43x43 TM5 Van der Waals
Peptide-19 I313 5.43x43 TM5 hydrophobic
Peptide-19 L314 5.44x44 TM5 hydrophobic
Peptide-19 L314 5.44x44 TM5 Van der Waals
Peptide-19 L388 7.43x42 TM7 Van der Waals
Peptide-19 L388 7.43x42 TM7 hydrophobic

Ligands

Peptide-19

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Residue Diagrams

V L A S F S L A Y G V T Y I I Y L F L L 1 L N L F A S F I L R A L S V F I K D A A 2 V L L W Y Y N A A V C Y Q M L L F V L R 3 I F R L Y V S G I W G V P L L F V V P W G 4 F I L F N V G I A F L I P L R I I L W Y N 5 L T L I P L L G T H E V I F A F V M 6 I A V M L G Q F S T F S L E T F L K I 7
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ICL1 R H L H ICL1ECL1 T A A Q Q H Q W D G L L S Y Q D S ECL1ICL2 S V L ICL2ECL2 D E G C W T R N S ECL2ICL3 M ICL3ECL3 D E H A R ECL3N-term M A G A P G P L R L A L L L L G M V G R A G P R P Q G A T V S L W E T V Q K W R E Y R R Q C Q R S L T E D P P P A T D L F C N R T F D E Y A C W P D G E P G S F V N V S C P W Y L P W A S S V P Q G H V Y R F C T A E G L W L Q K D N S S L P W R D L S E C E E S K R G E R S S P N-termC-term S M K P L K C P T S S L S S G A T A G S S M Y T A T C Q A S C S C-term E E Q L L F L Y I I Y T V G Y A L S F S A L V I A S A I L L G F C T R N Y I H L N L F A S F I L R A L S V F I K D A A L K W M Y S L S C R L V F L L M Q Y C V A A N Y Y W L L V E G V Y L Y T L L A F S E Q W I F R L Y V S I G W G V P L L F V V P W G I V K Y L Y E N M N Y W L I I R L P I L F A I G V N F L I F V R V I C I V V S K L K A N L C K T D I K C R L A K S T L T L I P L L G T H E V I F A F V M G T L R F I K L F T E L S F T S F Q G L M V A I L Y C F V N N E F R K W R L I Q R V Q L E S W E R E H L H D S
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Residue Table


GPCRdb(A)
GPCRdb(B)
GLP-1 receptor
TM1
1x29 1.33x33 E138
1x32 1.36x36 L141
1x35 1.39x39 L144
1x36 1.40x40 Y145
1x39 1.43x43 Y148
TM2
2x53 2.60x60 R190
2x60 2.67x67 K197
2x64 2.71x71 L201
2x65 2.72x72 K202
2x68 2.75x75 Y205
TM5
5x44 5.40x40 R310
5x47 5.43x43 I313
5x48 5.44x44 L314
TM7
7x38 7.43x42 L388