Structure information

M4 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7TRP

SPECIES

Homo sapiens

RESOLUTION

2.400

PREFERRED CHAIN

R

REFERENCE

PUBLICATION DATE

May 17, 2023
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Ligand Interaction Browser

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LigandAmino AcidGeneric NumberSegmentInteraction Type
Ligand
Amino Acid
Generic Number
Segment
Interaction Type
Ligand
Amino Acid
Generic Number
Segment
Interaction Type
LY2033298 Y89 2.61x60 TM2 polar (hydrogen bond)
LY2033298 Y89 2.61x60 TM2 Van der Waals
LY2033298 Y92 2.64x63 TM2 hydrophobic
LY2033298 Y92 2.64x63 TM2 Van der Waals
LY2033298 F186 45.51x51 ECL2 aromatic (face-to-face)
LY2033298 F186 45.51x51 ECL2 Van der Waals
LY2033298 L190 ECL2 Van der Waals
LY2033298 L190 ECL2 hydrophobic
LY2033298 N423 6.58x58 TM6 Van der Waals
LY2033298 D432 7.32x31 TM7 Van der Waals
LY2033298 W435 7.35x34 TM7 Van der Waals
LY2033298 W435 7.35x34 TM7 aromatic (face-to-face)
LY2033298 Y439 7.39x38 TM7 Van der Waals
LigandAmino AcidGeneric NumberSegmentInteraction Type
Showing 1 to 13 of 13 entries

Ligands

LY2033298

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Residue Diagrams

I N G V V T V L S L S G T V T A I F V M 1 F S L A C A D L I I G F A S M N L Y T V Y 2 I L L N M V S A N S V V Y D L A L W L D 3 A G L M I A A A W V L S F V L W A P A I 4 Y L V T M I V V P L Y F A A I A T G F T V 5 F A I L L A F I L T W T P Y N V M V L V 6 A P N I T S N V Y C L W Y G I S W V T 7
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ICL1 ECL1 ICL2 ECL2 ICL3 ECL3 N-term C-term R Y E T V E M V F I A T V T G S L S L V T V V G N I L V M L S I K V N T V N N Y F L F S L A C A D L I I G A F S M N L Y T V Y I I K G G A V V C D L W L A L D Y V V S N A S V M N L L I I S F D R Y F C V T K T T K M A G L M I A A A W V L S F V L W A P A I L F W Q F V V G N P A V T F G T A I A A F Y L P V V I M T V L Y I H I S L A S R S R V H K H R P E R Q M A A R E R K V T R T I F A I L L A F I L T W T P Y N V M V L V N T F C P D T V W S I G Y W L C Y V N S T I N P A C Y A L C N A T F R H Q F K K T L L L C
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Residue Table


GPCRdb(A)
GPCRdb(A)
M4 receptor
TM2
2x60 2.61x60 Y89
2x63 2.64x63 Y92
ECL2
45x51 45.51x51 F186
TM6
6x58 6.58x58 N423
TM7
7x31 7.32x31 D432
7x34 7.35x34 W435
7x38 7.39x38 Y439