Structure information

CT receptor

PROTEIN CLASS

Class B1 (Secretin)

PDB CODE

7TYL

SPECIES

Homo sapiens

RESOLUTION

3.300

PREFERRED CHAIN

R

REFERENCE

10.1126/SCIENCE.ABM9609

PUBLICATION DATE

March 23, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Amylin rat W79 N-term aromatic (face-to-edge)
Amylin rat F99 N-term hydrophobic
Amylin rat W128 N-term hydrophobic
Amylin rat Y131 N-term hydrophobic
Amylin rat L142 1.33x33 TM1 hydrophobic
Amylin rat A145 1.36x36 TM1 hydrophobic
Amylin rat Y146 1.37x37 TM1 polar (hydrogen bond)
Amylin rat Y146 1.37x37 TM1 Van der Waals
Amylin rat L148 1.39x39 TM1 Van der Waals
Amylin rat L148 1.39x39 TM1 hydrophobic
Amylin rat Y149 1.40x40 TM1 Van der Waals
Amylin rat Y149 1.40x40 TM1 hydrophobic
Amylin rat V206 ECL1 hydrophobic
Amylin rat V206 ECL1 Van der Waals
Amylin rat P207 ECL1 polar (hydrogen bond with backbone)
Amylin rat P207 ECL1 Van der Waals
Amylin rat N208 ECL1 Van der Waals
Amylin rat G209 ECL1 Van der Waals
Amylin rat Q227 3.37x37 TM3 polar (hydrogen bond)
Amylin rat M230 3.40x40 TM3 polar (hydrogen bond)
Amylin rat Y234 3.44x44 TM3 Van der Waals
Amylin rat Y234 3.44x44 TM3 hydrophobic
Amylin rat L291 45.52x52 ECL2 polar (hydrogen bond with backbone)
Amylin rat L291 45.52x52 ECL2 Van der Waals
Amylin rat V293 ECL2 Van der Waals
Amylin rat V293 ECL2 polar (hydrogen bond with backbone)
Amylin rat E294 ECL2 Van der Waals
Amylin rat E294 ECL2 polar (hydrogen bond with backbone)
Amylin rat H296 ECL2 Van der Waals
Amylin rat Y299 5.37x38 TM5 Van der Waals
Amylin rat Y299 5.37x38 TM5 hydrophobic
Amylin rat H302 5.40x40 TM5 polar (hydrogen bond)
Amylin rat H302 5.40x40 TM5 polar (hydrogen bond)
Amylin rat M306 5.44x44 TM5 Van der Waals
Amylin rat M306 5.44x44 TM5 hydrophobic
Amylin rat F356 6.53x53 TM6 hydrophobic
Amylin rat F356 6.53x53 TM6 Van der Waals
Amylin rat R362 ECL3 Van der Waals
Amylin rat Y372 7.38x37 TM7 Van der Waals
Amylin rat H377 7.43x42 TM7 polar (hydrogen bond)
Amylin rat H377 7.43x42 TM7 Van der Waals
Amylin rat H381 7.47x46 TM7 Van der Waals

Ligands

Amylin rat

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Residue Diagrams

V L T F I S L S H G V I A L Y Y L V Y A 1 K N M F L T Y I L N S M I I I I H L V E 2 C L M W F Y N C A M M Y Q H F F H L I K 3 R L R W Y Y L G L W G F P L V P T T I H A 4 L F F F N V V L A A M V P G H I I Y L 5 M I L V P L L G I Q F V V F P W 6 T A V F F G Q F H I L S H M V Y D Y I 7
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ICL1 R S L G ICL1ECL1 V P N G E L V R R D ECL1ICL2 A V F T E K Q ICL2ECL2 N D N C W L S V E T H L ECL2ICL3 E ICL3ECL3 R P S ECL3N-term M R F T F T S R C L A L F L L L N H P T P I L P A F S N Q T Y P T I E P K P F L Y V V G R K K M M D A Q Y K C Y D R M Q Q L P A Y Q G E G P Y C N R T W D G W L C W D D T P A G V L S Y Q F C P D Y F P D F D P S E K V T K Y C D E K G V W F K H P E N N R T W S N Y N-termC-term P S N R S A R A A A A A A E A G D I P I Y I C H Q E L R N E P A N N Q G E E S A E I I P L N I I E Q E S S A C-term T M C N A F T P E K L K N A Y V L Y Y L A I V G H S L S I F T L V I S L G I F V F F C Q R V T L H K N M F L T Y I L N S M I I I I H L V E V P V S C K I L H F F H Q Y M M A C N Y F W M L C E G I Y L H T L I V V R L R W Y Y L L G W G F P L V P T T I H A I T R A V Y F L Y I I H G P V M A A L V V N F F F L L N I V R V L V T K M R E T H A E S H M Y L K A V K A T M I L V P L L G I Q F V V F P W N K M L G K I Y D Y V M H S L I H F Q G F F V A T I Y C F C N N E V K R F K I R W G V Q T T Q W A Q Q W N Q R R
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Residue Table


GPCRdb(A)
GPCRdb(B)
CT receptor
TM1
1x29 1.33x33 L142
1x32 1.36x36 A145
1x33 1.37x37 Y146
1x35 1.39x39 L148
1x36 1.40x40 Y149
TM3
3x33 3.37x37 Q227
3x36 3.40x40 M230
3x40 3.44x44 Y234
ECL2
45x52 45.52x52 L291
TM5
5x42 5.37x38 Y299
5x44 5.40x40 H302
5x48 5.44x44 M306
TM6
6x48 6.53x53 F356
TM7
7x33 7.38x37 Y372
7x38 7.43x42 H377
7x42 7.47x46 H381