Structure information

5-HT5A receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7UM4

SPECIES

Homo sapiens

RESOLUTION

2.800

PREFERRED CHAIN

A

REFERENCE

10.1038/S41594-022-00796-6

PUBLICATION DATE

July 20, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
CHEMBL3654198 E101 2.65x64 TM2 polar (charge-assisted hydrogen bond)
CHEMBL3654198 W117 3.28x28 TM3 Van der Waals
CHEMBL3654198 D121 3.32x32 TM3 polar (charge-assisted hydrogen bond)
CHEMBL3654198 V122 3.33x33 TM3 hydrophobic
CHEMBL3654198 V122 3.33x33 TM3 Van der Waals
CHEMBL3654198 C125 3.36x36 TM3 Van der Waals
CHEMBL3654198 T126 3.37x37 TM3 Van der Waals
CHEMBL3654198 T126 3.37x37 TM3 polar (hydrogen bond)
CHEMBL3654198 V194 45.52x52 ECL2 hydrophobic
CHEMBL3654198 V194 45.52x52 ECL2 Van der Waals
CHEMBL3654198 S195 ECL2 Van der Waals
CHEMBL3654198 Y200 5.38x39 TM5 hydrophobic
CHEMBL3654198 Y200 5.38x39 TM5 Van der Waals
CHEMBL3654198 A201 5.39x40 TM5 Van der Waals
CHEMBL3654198 A201 5.39x40 TM5 hydrophobic
CHEMBL3654198 S204 5.42x43 TM5 polar (hydrogen bond)
CHEMBL3654198 S204 5.42x43 TM5 Van der Waals
CHEMBL3654198 T205 5.43x44 TM5 Van der Waals
CHEMBL3654198 A208 5.46x461 TM5 hydrophobic
CHEMBL3654198 A208 5.46x461 TM5 Van der Waals
CHEMBL3654198 F301 6.51x51 TM6 Van der Waals
CHEMBL3654198 F301 6.51x51 TM6 hydrophobic
CHEMBL3654198 F302 6.52x52 TM6 aromatic (edge-to-face)
CHEMBL3654198 F302 6.52x52 TM6 Van der Waals
CHEMBL3654198 E305 6.55x55 TM6 polar (charge-assisted hydrogen bond)
CHEMBL3654198 L324 7.39x38 TM7 hydrophobic
CHEMBL3654198 L324 7.39x38 TM7 Van der Waals
CHEMBL3654198 Y328 7.43x42 TM7 polar (hydrogen bond)

Ligands

CHEMBL3654198

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Residue Diagrams

L N W A F T A A V L F G L L T L I L V G 1 A S M A V S D V L V A L A V M P L S L V H 2 A T V N W I S A T C C L V D C A I W L Q 3 S N V M I A L T W A L S A V I S L A P L 4 Y V F L V V C L P L Y F A G V T S F V A Y 5 G I L I G V F V L C W I P F F L T E L I 6 L P N F F S N S Y G L W L F I S K W I 7
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ICL1 R T F H ICL1ECL1 R R W Q L ECL1ICL2 H M E Y T ICL2ECL2 W G E T Y S E G S E E C Q V S R ECL2ICL3 V S P I S E A V E V K D S A K Q P Q M V F T V R H A T V T F Q P E G D ICL3ECL3 S C D I ECL3N-term M D L P V N L T S F S L S T P S P L E T N H S L G K D D L R P S S P L N-termC-term S R Q H C-term L S V F G V L I L T L L G F L V A A T F A W N L L V L A T I L R V R V P H N L V A S M A V S D V L V A A L V M P L S L V H E L S G G R R L C Q L W I A C D V L C C T A S I W N V T A I A L D R Y W S I T R L R T R K C V S N V M I A L T W A L S A V I S L A P L L F G E P S Y A V F S T V G A F Y L P L C V V L F V Y W K I Y K A A K F R V G S R K T N S T W R E Q K E Q R A A L M V G I L I G V F V L C W I P F F L T E L I S P L C P A I W K S I F L W L G Y S N S F F N P L I Y T A F N K N F K N Y N S A F F
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Residue Table


GPCRdb(A)
GPCRdb(A)
5-HT5A receptor
TM2
2x64 2.65x64 E101
TM3
3x28 3.28x28 W117
3x32 3.32x32 D121
3x33 3.33x33 V122
3x36 3.36x36 C125
3x37 3.37x37 T126
ECL2
45x52 45.52x52 V194
TM5
5x39 5.38x39 Y200
5x40 5.39x40 A201
5x43 5.42x43 S204
5x44 5.43x44 T205
5x461 5.46x461 A208
TM6
6x51 6.51x51 F301
6x52 6.52x52 F302
6x55 6.55x55 E305
TM7
7x38 7.39x38 L324
7x42 7.43x42 Y328