Structure information

5-HT5A receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7UM7

SPECIES

Homo sapiens

RESOLUTION

2.750

PREFERRED CHAIN

A

REFERENCE

10.1038/S41594-022-00796-6

PUBLICATION DATE

July 20, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
methylergonovine W117 3.28x28 TM3 hydrophobic
methylergonovine V122 3.33x33 TM3 hydrophobic
methylergonovine C125 3.36x36 TM3 hydrophobic
methylergonovine T126 3.37x37 TM3 Van der Waals
methylergonovine T126 3.37x37 TM3 polar (hydrogen bond)
methylergonovine S204 5.42x43 TM5 Van der Waals
methylergonovine W298 6.48x48 TM6 Van der Waals
methylergonovine F301 6.51x51 TM6 Van der Waals
methylergonovine F301 6.51x51 TM6 hydrophobic
methylergonovine F302 6.52x52 TM6 aromatic (edge-to-face)
methylergonovine F302 6.52x52 TM6 Van der Waals
methylergonovine L324 7.39x38 TM7 hydrophobic
methylergonovine L324 7.39x38 TM7 Van der Waals
methylergonovine Y328 7.43x42 TM7 Van der Waals

Ligands

methylergonovine

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Residue Diagrams

L N W A F T A A V L F G L L T L I L V G 1 A S M A V S D V L V A L A V M P L S L V H 2 A T V N W I S A T C C L V D C A I W L Q 3 S N V M I A L T W A L S A V I S L A P L 4 Y V F L V V C L P L Y F A G V T S F V A Y 5 G I L I G V F V L C W I P F F L T E L I 6 L P N F F S N S Y G L W L F I S K W I 7
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ICL1 R T F H ICL1ECL1 R R W Q L ECL1ICL2 H M E Y T ICL2ECL2 W G E T Y S E G S E E C Q V S R ECL2ICL3 V S P I S E A V E V K D S A K Q P Q M V F T V R H A T V T F Q P E G D ICL3ECL3 S C D I ECL3N-term M D L P V N L T S F S L S T P S P L E T N H S L G K D D L R P S S P L N-termC-term S R Q H C-term L S V F G V L I L T L L G F L V A A T F A W N L L V L A T I L R V R V P H N L V A S M A V S D V L V A A L V M P L S L V H E L S G G R R L C Q L W I A C D V L C C T A S I W N V T A I A L D R Y W S I T R L R T R K C V S N V M I A L T W A L S A V I S L A P L L F G E P S Y A V F S T V G A F Y L P L C V V L F V Y W K I Y K A A K F R V G S R K T N S T W R E Q K E Q R A A L M V G I L I G V F V L C W I P F F L T E L I S P L C P A I W K S I F L W L G Y S N S F F N P L I Y T A F N K N F K N Y N S A F F
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Residue Table


GPCRdb(A)
GPCRdb(A)
5-HT5A receptor
TM3
3x28 3.28x28 W117
3x33 3.33x33 V122
3x36 3.36x36 C125
3x37 3.37x37 T126
TM5
5x43 5.42x43 S204
TM6
6x48 6.48x48 W298
6x51 6.51x51 F301
6x52 6.52x52 F302
TM7
7x38 7.39x38 L324
7x42 7.43x42 Y328