PDB
7V35
Resolution
3.4 Å
Released
March 2, 2022
Receptor
glucagon
Class
B1
Species
Homo sapiens
Ligand
Peptide 20
Function
Agonist
Reference
10.1038/S41467-022-28683-0

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Ligand Amino Acid Generic Number Segment Interaction Type
Peptide 20 V28 N-term hydrophobic
Peptide 20 M29 N-term hydrophobic
Peptide 20 L32 N-term hydrophobic
Peptide 20 W36 N-term aromatic (face-to-edge)
Peptide 20 Y65 N-term hydrophobic
Peptide 20 P114 N-term polar (hydrogen bond with backbone)
Peptide 20 P114 N-term Van der Waals
Peptide 20 R116 N-term Van der Waals
Peptide 20 Q131 1.29x29 TM1 Van der Waals
Peptide 20 A135 1.33x33 TM1 hydrophobic
Peptide 20 A135 1.33x33 TM1 Van der Waals
Peptide 20 Y138 1.36x36 TM1 Van der Waals
Peptide 20 Y138 1.36x36 TM1 hydrophobic
Peptide 20 S139 1.37x37 TM1 polar (hydrogen bond)
Peptide 20 S139 1.37x37 TM1 Van der Waals
Peptide 20 F141 1.39x39 TM1 hydrophobic
Peptide 20 Q142 1.40x40 TM1 polar (hydrogen bond)
Peptide 20 V143 1.41x41 TM1 Van der Waals
Peptide 20 Y145 1.43x43 TM1 Van der Waals
Peptide 20 Y145 1.43x43 TM1 hydrophobic
Peptide 20 T146 1.44x44 TM1 Van der Waals
Peptide 20 L192 2.65x65 TM2 hydrophobic
Peptide 20 L192 2.65x65 TM2 Van der Waals
Peptide 20 L198 2.71x71 TM2 hydrophobic
Peptide 20 L198 2.71x71 TM2 Van der Waals
Peptide 20 R199 2.72x72 TM2 polar (charge-assisted hydrogen bond)
Peptide 20 Y202 2.75x75 TM2 polar (hydrogen bond with backbone)
Peptide 20 Y202 2.75x75 TM2 Van der Waals
Peptide 20 K205 ECL1 Van der Waals
Peptide 20 I206 ECL1 Van der Waals
Peptide 20 I206 ECL1 polar (hydrogen bond with backbone)
Peptide 20 G207 ECL1 Van der Waals
Peptide 20 D208 ECL1 Van der Waals
Peptide 20 D209 ECL1 Van der Waals
Peptide 20 Q232 3.37x37 TM3 polar (hydrogen bond)
Peptide 20 I235 3.40x40 TM3 hydrophobic
Peptide 20 I235 3.40x40 TM3 Van der Waals
Peptide 20 T296 45.52x52 ECL2 Van der Waals
Peptide 20 S297 ECL2 polar (hydrogen bond)
Peptide 20 S297 ECL2 Van der Waals
Peptide 20 N298 ECL2 polar (hydrogen bond)
Peptide 20 N298 ECL2 Van der Waals
Peptide 20 W304 5.36x37 TM5 Van der Waals
Peptide 20 W304 5.36x37 TM5 hydrophobic
Peptide 20 D370 ECL3 Van der Waals
Peptide 20 R378 7.35x34 TM7 polar (charge-assisted hydrogen bond)
Peptide 20 L382 7.39x38 TM7 Van der Waals
Peptide 20 L382 7.39x38 TM7 hydrophobic
Peptide 20 D385 7.42x41 TM7 Van der Waals
Peptide 20 L386 7.43x42 TM7 Van der Waals
Peptide 20 L386 7.43x42 TM7 hydrophobic

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ICL1 S K L H ICL1ECL1 Q K I G D D L S V S T W L S D G ECL1ICL2 A T L P E R ICL2ECL2 N V Q C W T S N D N M G F ECL2ICL3 R Q M H H T ICL3ECL3 E H A Q ECL3N-term M P P C Q P Q R P L L L L L L L L A C Q P Q V P S A Q V M D F L F E K W K L Y G D Q C H H N L S L L P P P T E L V C N R T F D K Y S C W P D T P A N T T A N I S C P W Y L P W H H K V Q H R F V F K R C G P D G Q W V R G P R G Q P W R D A S Q C Q M D G E E I E V N-termC-term T S N H R A S S S P G H G P P S K E L Q F G R G G G S Q D S S A E T P L A G G L P R L A E S P F C-term Q K E V A K M Y S S F Q V M Y T V G Y S L S L G A L L L A L A I L G G L C T R N A I H A N L F A S F V L K A S S V L V I D G L L R T R Y S A V A G C R V A A V F M Q Y G I V A N Y C W L L V E G L Y L H N L L G L S F F S L Y L G I G W G A P M L F V V P W A V V K C L F E W W I L R F P V F L A I L I N F F I F V R I V Q L L V A K L R A D Y K F R L A K S T L T L I P L L G V H E V V F A F V T D G T L R S A K L F F D L F L S S F Q G L L V A V L Y C F L N K E L R R W R L W E E V Q S E R W H R G K V L R N
Helix box plot — Download: PNG | SVG L L A G L S L S Y G V T Y M V Q F S S Y 1 A N L F A S F V L K A S S V L V I D G L 2 V L L W C Y N A V I G Y Q M F V A A V R 3 F F S L Y L G G I W G A P M L F V V P W A 4 F I F F N I L I A L F V P F R L I W W 5 L T L I P L L G V H E V V F A F V T D 6 V A V L L G Q F S S L F L D F F L K A 7

GPCRdb(A)
GPCRdb(B)
glucagon receptor
TM1
1x25 1.29x29 Q131
1x29 1.33x33 A135
1x32 1.36x36 Y138
1x33 1.37x37 S139
1x35 1.39x39 F141
1x36 1.40x40 Q142
1x37 1.41x41 V143
1x39 1.43x43 Y145
1x40 1.44x44 T146
TM2
2x58 2.65x65 L192
2x64 2.71x71 L198
2x65 2.72x72 R199
2x68 2.75x75 Y202
TM3
3x33 3.37x37 Q232
3x36 3.40x40 I235
ECL2
45x52 45.52x52 T296
TM5
5x41 5.36x37 W304
TM7
7x30 7.35x34 R378
7x34 7.39x38 L382
7x37 7.42x41 D385
7x38 7.43x42 L386