PDB
7VIH
Resolution
3.0 Å
Released
Sept. 28, 2022
Receptor
S1P1
Class
A
Species
Homo sapiens
Ligand
Function
icanbelimod
Agonist
Reference
10.1073/PNAS.2117716119

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file
Download list in excel
Ligand Amino Acid Generic Number Segment Interaction Type
icanbelimod Y29 N-term Van der Waals
icanbelimod K34 N-term polar (charge-charge)
icanbelimod K34 N-term polar (hydrogen bond)
icanbelimod N101 2.60x60 TM2 Van der Waals
icanbelimod S105 ECL1 Van der Waals
icanbelimod G106 23.47x47 ECL1 Van der Waals
icanbelimod R120 3.28x28 TM3 Van der Waals
icanbelimod E121 3.29x29 TM3 Van der Waals
icanbelimod M124 3.32x32 TM3 Van der Waals
icanbelimod F125 3.33x33 TM3 aromatic (face-to-face)
icanbelimod F125 3.33x33 TM3 hydrophobic
icanbelimod L128 3.36x36 TM3 hydrophobic
icanbelimod S129 3.37x37 TM3 Van der Waals
icanbelimod V132 3.40x40 TM3 hydrophobic
icanbelimod V194 ECL2 Van der Waals
icanbelimod L195 ECL2 Van der Waals
icanbelimod F210 5.47x47 TM5 hydrophobic
icanbelimod W269 6.48x48 TM6 Van der Waals
icanbelimod L272 6.51x51 TM6 hydrophobic
icanbelimod L276 6.55x55 TM6 hydrophobic
icanbelimod L297 7.39x38 TM7 hydrophobic

NGL is a WebGL based 3D viewer powered by MMTF.

Download PDB file

Snake plot — Download: PNG | SVG
ICL1 K K F H ICL1ECL1 G A T T Y K L ECL1ICL2 M K L H N G S ICL2ECL2 W N C I S A L S S C S T V L P L Y ECL2ICL3 F R K N I S K A ICL3ECL3 K V K T C ECL3N-term M G P T S V P L V K A H R S S V S D Y V N Y D I I V R H Y N Y T G K L N I S A D K N-termC-term C C K C P S G D S A G K F K R P I I A G M E F S R S K S D N S S H P Q K D E G D N P E T I M S S G N V N S S S C-term E N S I K L T S V V F I L I C C F I I L E N I F V L L T I W K T R P M Y Y F I G N L A L S D L L A G V A Y T A N L L L S T P A Q W F L R E G S M F V A L S A S V F S L L A I A I E R Y I T M L K N N F R L F L L I S A C W V I S L I L G G L P I M G H K H Y I L F C T T V F T L L L L S I V I L Y C R I Y S L V R T R S R R L T S R S S E K S L A L L K T V I I V L S V F I A C W A P L F I L L L L D V G C D I L F R A E Y F L V L A V L N S G T N P I I Y T L T N K E F I R M R R A I M S
Helix box plot — Download: PNG | SVG I N E L I I F C C I L I F V V S T L K I 1 G N L A L S D L L A G V A Y T A N L L L 2 A L L S F V S A S L A V F M S G E R L F 3 L F L L I S A C W V I S L I L G G L P I 4 Y L I V I S L L L L T F V T T C F L I Y 5 I I V L S V F I A C W A P L F I L L L L 6 I P N T G S N L V A L V L F Y E A R F 7

GPCRdb(A)
GPCRdb(A)
S1P1 receptor
TM2
2x60 2.60x60 N101
ECL1
23x47 23.47x47 G106
TM3
3x28 3.28x28 R120
3x29 3.29x29 E121
3x32 3.32x32 M124
3x33 3.33x33 F125
3x36 3.36x36 L128
3x37 3.37x37 S129
3x40 3.40x40 V132
TM5
5x47 5.47x47 F210
TM6
6x48 6.48x48 W269
6x51 6.51x51 L272
6x55 6.55x55 L276
TM7
7x38 7.39x38 L297