PDB
7VLA
Resolution
2.7 Å
Released
March 23, 2022
Receptor
CCR1
Class
A
Species
Homo sapiens
Ligand
Function
CCL15(27-92) (CCL15M)
Agonist
Reference
10.1038/S41589-021-00918-Z

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Ligand Amino Acid Generic Number Segment Interaction Type
CCL15(27-92) (CCL15M) D17 N-term polar (hydrogen bond)
CCL15(27-92) (CCL15M) Y18 N-term hydrophobic
CCL15(27-92) (CCL15M) Y18 N-term polar (hydrogen bond)
CCL15(27-92) (CCL15M) G19 N-term Van der Waals
CCL15(27-92) (CCL15M) D20 N-term polar (hydrogen bond)
CCL15(27-92) (CCL15M) A21 N-term hydrophobic
CCL15(27-92) (CCL15M) T22 N-term Van der Waals
CCL15(27-92) (CCL15M) P23 N-term hydrophobic
CCL15(27-92) (CCL15M) Q25 N-term polar (hydrogen bond)
CCL15(27-92) (CCL15M) K26 1.24x24 TM1 polar (hydrogen bond with backbone)
CCL15(27-92) (CCL15M) R30 1.28x28 TM1 polar (charge-charge)
CCL15(27-92) (CCL15M) R30 1.28x28 TM1 polar (hydrogen bond)
CCL15(27-92) (CCL15M) W90 2.60x60 TM2 aromatic (pi-cation)
CCL15(27-92) (CCL15M) Y93 2.63x63 TM2 hydrophobic
CCL15(27-92) (CCL15M) Y93 2.63x63 TM2 aromatic (edge-to-face)
CCL15(27-92) (CCL15M) K94 2.64x64 TM2 polar (hydrogen bond)
CCL15(27-92) (CCL15M) K94 2.64x64 TM2 hydrophobic
CCL15(27-92) (CCL15M) D97 2.67x67 TM2 Van der Waals
CCL15(27-92) (CCL15M) K173 ECL2 polar (charge-charge)
CCL15(27-92) (CCL15M) Q175 ECL2 hydrophobic
CCL15(27-92) (CCL15M) Q175 ECL2 polar (hydrogen bond)
CCL15(27-92) (CCL15M) Q175 ECL2 polar (hydrogen bond)
CCL15(27-92) (CCL15M) W176 ECL2 Van der Waals
CCL15(27-92) (CCL15M) E177 ECL2 Van der Waals
CCL15(27-92) (CCL15M) F178 ECL2 hydrophobic
CCL15(27-92) (CCL15M) S184 45.51x51 ECL2 Van der Waals
CCL15(27-92) (CCL15M) L185 45.52x52 ECL2 Van der Waals
CCL15(27-92) (CCL15M) H186 ECL2 polar (hydrogen bond)
CCL15(27-92) (CCL15M) F187 ECL2 Van der Waals
CCL15(27-92) (CCL15M) H189 ECL2 polar (hydrogen bond)
CCL15(27-92) (CCL15M) E190 ECL2 Van der Waals
CCL15(27-92) (CCL15M) L192 5.31x32 TM5 hydrophobic
CCL15(27-92) (CCL15M) R193 5.32x33 TM5 polar (hydrogen bond)
CCL15(27-92) (CCL15M) K196 5.35x36 TM5 polar (hydrogen bond)
CCL15(27-92) (CCL15M) Q265 6.61x61 TM6 Van der Waals
CCL15(27-92) (CCL15M) D266 ECL3 Van der Waals
CCL15(27-92) (CCL15M) E272 ECL3 hydrophobic
CCL15(27-92) (CCL15M) C273 ECL3 hydrophobic
CCL15(27-92) (CCL15M) D280 7.32x31 TM7 polar (charge-charge)
CCL15(27-92) (CCL15M) D280 7.32x31 TM7 hydrophobic
CCL15(27-92) (CCL15M) V283 7.35x34 TM7 hydrophobic
CCL15(27-92) (CCL15M) Q284 7.36x35 TM7 polar (hydrogen bond)
CCL15(27-92) (CCL15M) E287 7.39x38 TM7 polar (charge-charge)

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ICL1 K R L K ICL1ECL1 D W V F ECL1ICL2 A V F A L R A R ICL2ECL2 K T Q W E F T H H T C S L H F P H E ECL2ICL3 R P ICL3ECL3 T H ECL3N-term M E T P N T T E D Y D T T T E F D Y G D A T P C Q N-termC-term R V A V H L V K W L P F L S V D R L E R V S S T S P S T G E H E L S A G F C-term K V N E R A F G A Q L L P P L Y S L V F V I G L V G N I L V V L V L V Q Y N M T S I Y L L N L A I S D L L F L F T L P F W I D Y K L K D G D A M C K I L S G F Y Y T G L Y S E I F F I I L L T I D R Y L A I V H T V T F G V I T S I I I W A L A I L A S M P G L Y F S S L R E W K L F Q A L K L N L F G L V L P L L V M I I C Y T G I I K I L L R N E K K S K A V R L I F V I M I I F F L F W T P Y N L T I L I S V F Q D F L F E C E Q S R H L D L A V Q V T E V I A Y T H C C V N P V I Y A F V G E R L R Q F R K Y L F H R
Helix box plot — Download: PNG | SVG I N G V L G I V F V L S Y L P P L L Q A 1 L N L A I S D L L F L F T L P F W I D Y 2 L I I F F I E S Y L G T Y Y F G S L I K 3 G V I T S I I I W A L A I L A S M P G 4 Y C I I M V L L P L V L G F L N L K L A Q 5 F V I M I I F F L F W T P Y N L T I L I 6 V P N V C C H T Y A I V E T V Q V A L 7

GPCRdb(A)
GPCRdb(A)
CCR1
TM1
1x24 1.24x24 K26
1x28 1.28x28 R30
TM2
2x60 2.60x60 W90
2x63 2.63x63 Y93
2x64 2.64x64 K94
2x67 2.67x67 D97
ECL2
45x51 45.51x51 S184
45x52 45.52x52 L185
TM5
5x32 5.31x32 L192
5x33 5.32x33 R193
5x36 5.35x36 K196
TM6
6x61 6.61x61 Q265
TM7
7x31 7.32x31 D280
7x34 7.35x34 V283
7x35 7.36x35 Q284
7x38 7.39x38 E287