PDB
7W40
Resolution
3.0 Å
Released
Feb. 22, 2023
Receptor
BB2
Class
A
Species
Homo sapiens
Ligand
Function
Bombesin (6-14) [D-Phe6, beta-Ala11, Phe13, Nle14] Bn (6-14)
Agonist
Reference
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Ligand Amino Acid Generic Number Segment Interaction Type
Bombesin (6-14) [D-Phe6, beta-Ala11, Phe13, Nle14] Bn (6-14) C93 2.57x56 TM2 Van der Waals
Bombesin (6-14) [D-Phe6, beta-Ala11, Phe13, Nle14] Bn (6-14) D97 2.61x60 TM2 Van der Waals
Bombesin (6-14) [D-Phe6, beta-Ala11, Phe13, Nle14] Bn (6-14) R100 2.64x63 TM2 polar (hydrogen bond)
Bombesin (6-14) [D-Phe6, beta-Ala11, Phe13, Nle14] Bn (6-14) R100 2.64x63 TM2 hydrophobic
Bombesin (6-14) [D-Phe6, beta-Ala11, Phe13, Nle14] Bn (6-14) Y101 2.65x64 TM2 hydrophobic
Bombesin (6-14) [D-Phe6, beta-Ala11, Phe13, Nle14] Bn (6-14) A103 2.67x66 TM2 Van der Waals
Bombesin (6-14) [D-Phe6, beta-Ala11, Phe13, Nle14] Bn (6-14) D104 ECL1 Van der Waals
Bombesin (6-14) [D-Phe6, beta-Ala11, Phe13, Nle14] Bn (6-14) W106 23.50x50 ECL1 Van der Waals
Bombesin (6-14) [D-Phe6, beta-Ala11, Phe13, Nle14] Bn (6-14) P117 3.29x29 TM3 Van der Waals
Bombesin (6-14) [D-Phe6, beta-Ala11, Phe13, Nle14] Bn (6-14) Q120 3.32x32 TM3 Van der Waals
Bombesin (6-14) [D-Phe6, beta-Ala11, Phe13, Nle14] Bn (6-14) L121 3.33x33 TM3 hydrophobic
Bombesin (6-14) [D-Phe6, beta-Ala11, Phe13, Nle14] Bn (6-14) V124 3.36x36 TM3 hydrophobic
Bombesin (6-14) [D-Phe6, beta-Ala11, Phe13, Nle14] Bn (6-14) S179 ECL2 Van der Waals
Bombesin (6-14) [D-Phe6, beta-Ala11, Phe13, Nle14] Bn (6-14) F184 ECL2 hydrophobic
Bombesin (6-14) [D-Phe6, beta-Ala11, Phe13, Nle14] Bn (6-14) E186 ECL2 hydrophobic
Bombesin (6-14) [D-Phe6, beta-Ala11, Phe13, Nle14] Bn (6-14) F193 ECL2 hydrophobic
Bombesin (6-14) [D-Phe6, beta-Ala11, Phe13, Nle14] Bn (6-14) S195 ECL2 Van der Waals
Bombesin (6-14) [D-Phe6, beta-Ala11, Phe13, Nle14] Bn (6-14) C196 45.50x50 ECL2 Van der Waals
Bombesin (6-14) [D-Phe6, beta-Ala11, Phe13, Nle14] Bn (6-14) A197 45.51x51 ECL2 Van der Waals
Bombesin (6-14) [D-Phe6, beta-Ala11, Phe13, Nle14] Bn (6-14) P198 45.52x52 ECL2 Van der Waals
Bombesin (6-14) [D-Phe6, beta-Ala11, Phe13, Nle14] Bn (6-14) S214 5.42x43 TM5 Van der Waals
Bombesin (6-14) [D-Phe6, beta-Ala11, Phe13, Nle14] Bn (6-14) F218 5.46x461 TM5 aromatic (edge-to-face)
Bombesin (6-14) [D-Phe6, beta-Ala11, Phe13, Nle14] Bn (6-14) W277 6.48x48 TM6 hydrophobic
Bombesin (6-14) [D-Phe6, beta-Ala11, Phe13, Nle14] Bn (6-14) N280 6.51x51 TM6 Van der Waals
Bombesin (6-14) [D-Phe6, beta-Ala11, Phe13, Nle14] Bn (6-14) H281 6.52x52 TM6 aromatic (edge-to-face)
Bombesin (6-14) [D-Phe6, beta-Ala11, Phe13, Nle14] Bn (6-14) Y284 6.55x55 TM6 aromatic (edge-to-face)
Bombesin (6-14) [D-Phe6, beta-Ala11, Phe13, Nle14] Bn (6-14) Y284 6.55x55 TM6 hydrophobic
Bombesin (6-14) [D-Phe6, beta-Ala11, Phe13, Nle14] Bn (6-14) R287 6.58x58 TM6 polar (hydrogen bond)
Bombesin (6-14) [D-Phe6, beta-Ala11, Phe13, Nle14] Bn (6-14) V294 ECL3 hydrophobic
Bombesin (6-14) [D-Phe6, beta-Ala11, Phe13, Nle14] Bn (6-14) T296 ECL3 Van der Waals
Bombesin (6-14) [D-Phe6, beta-Ala11, Phe13, Nle14] Bn (6-14) H300 7.31x30 TM7 Van der Waals
Bombesin (6-14) [D-Phe6, beta-Ala11, Phe13, Nle14] Bn (6-14) F301 7.32x31 TM7 hydrophobic
Bombesin (6-14) [D-Phe6, beta-Ala11, Phe13, Nle14] Bn (6-14) F301 7.32x31 TM7 aromatic (edge-to-face)
Bombesin (6-14) [D-Phe6, beta-Ala11, Phe13, Nle14] Bn (6-14) R308 7.39x38 TM7 Van der Waals
Bombesin (6-14) [D-Phe6, beta-Ala11, Phe13, Nle14] Bn (6-14) A311 7.42x41 TM7 Van der Waals
Bombesin (6-14) [D-Phe6, beta-Ala11, Phe13, Nle14] Bn (6-14) F312 7.43x42 TM7 Van der Waals

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ICL1 K S M R ICL1ECL1 D R W L F ECL1ICL2 P M D I Q A S H ICL2ECL2 D L H P F H E E S T N Q T F I S C A P Y P H S ECL2ICL3 P V E G ICL3ECL3 Y S E V D T ECL3N-term M A L N D C F L L N L E V D H F M H C N I S S H S A D L P V N D D W S H N-termC-term C Q P G L I I R S H S T G R S T T C M T S L K S T N P S V A T F S L I N G N I C H E R Y V C-term P G I L Y V I P A V Y G V I I L I G L I G N I T L I K I F C T V N V P N L F I S S L A L G D L L L L I T C A P V D A S R Y L A G R I G C K L I P F I Q L T S V G V S V F T L T A L S A D R Y K A I V R A L M K I C L K A A F I W I I S M L L A I P E A V F S N E L H P K I H S M A S F L V F Y V I P L S I I S V Y Y Y F I A K N L I Q S A Y N L N I H V K K Q I E S R K R L A K T V L V F V G L F A F C W L P N H V I Y L Y R S Y H S M L H F V T S I C A R L L A F T N S C V N P F A L Y L L S K S F N T F R K Q Q L L C
Helix box plot — Download: PNG | SVG I N G I L G I L I I V G Y V A P I V Y L 1 S S L A L G D L L L L T I C A P V D A S R 2 A T L T F V S V G V S T L Q I F P I L K 3 I C L K A A F I W I I S M L L A I P E 4 Y Y V S I I S L P I V Y F V L F S A M S H 5 L V F V G L F A F C W L P N H V I Y L Y 6 F P N V C S N T F A L L R A C I S T V 7

GPCRdb(A)
GPCRdb(A)
BB2 receptor
TM2
2x56 2.57x56 C93
2x60 2.61x60 D97
2x63 2.64x63 R100
2x64 2.65x64 Y101
2x66 2.67x66 A103
ECL1
23x50 23.50x50 W106
TM3
3x29 3.29x29 P117
3x32 3.32x32 Q120
3x33 3.33x33 L121
3x36 3.36x36 V124
ECL2
45x50 45.50x50 C196
45x51 45.51x51 A197
45x52 45.52x52 P198
TM5
5x43 5.42x43 S214
5x461 5.46x461 F218
TM6
6x48 6.48x48 W277
6x51 6.51x51 N280
6x52 6.52x52 H281
6x55 6.55x55 Y284
6x58 6.58x58 R287
TM7
7x30 7.31x30 H300
7x31 7.32x31 F301
7x38 7.39x38 R308
7x41 7.42x41 A311
7x42 7.43x42 F312