Structure information

SST2 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7WIC

SPECIES

Homo sapiens

RESOLUTION

2.800

PREFERRED CHAIN

R

REFERENCE

10.1038/S41422-022-00669-Z

PUBLICATION DATE

June 1, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
SOMATOSTATIN Q126 3.36x36 TM3 Van der Waals
SOMATOSTATIN Q126 3.36x36 TM3 polar (hydrogen bond)
SOMATOSTATIN R184 ECL2 polar (charge-assisted hydrogen bond)
SOMATOSTATIN S192 ECL2 Van der Waals
SOMATOSTATIN S192 ECL2 polar (hydrogen bond)
SOMATOSTATIN C193 45.50x50 ECL2 Van der Waals
SOMATOSTATIN T194 45.51x51 ECL2 polar (hydrogen bond)
SOMATOSTATIN I195 45.52x52 ECL2 hydrophobic
SOMATOSTATIN I195 45.52x52 ECL2 Van der Waals
SOMATOSTATIN W197 ECL2 polar (hydrogen bond with backbone)
SOMATOSTATIN W197 ECL2 aromatic (edge-to-face)
SOMATOSTATIN W197 ECL2 Van der Waals
SOMATOSTATIN G199 ECL2 Van der Waals
SOMATOSTATIN Y205 5.35x36 TM5 aromatic (edge-to-face)
SOMATOSTATIN Y205 5.35x36 TM5 Van der Waals
SOMATOSTATIN Y205 5.35x36 TM5 polar (hydrogen bond)
SOMATOSTATIN F208 5.38x39 TM5 hydrophobic
SOMATOSTATIN I209 5.39x40 TM5 hydrophobic
SOMATOSTATIN I209 5.39x40 TM5 Van der Waals
SOMATOSTATIN T212 5.42x43 TM5 Van der Waals
SOMATOSTATIN F272 6.51x51 TM6 Van der Waals
SOMATOSTATIN F272 6.51x51 TM6 hydrophobic
SOMATOSTATIN F275 6.54x54 TM6 aromatic (edge-to-face)
SOMATOSTATIN F275 6.54x54 TM6 Van der Waals
SOMATOSTATIN N276 6.55x55 TM6 Van der Waals
SOMATOSTATIN S279 6.58x58 TM6 polar (hydrogen bond with backbone)
SOMATOSTATIN S279 6.58x58 TM6 polar (hydrogen bond)
SOMATOSTATIN S279 6.58x58 TM6 Van der Waals
SOMATOSTATIN P286 ECL3 Van der Waals
SOMATOSTATIN F294 7.35x34 TM7 hydrophobic
SOMATOSTATIN F294 7.35x34 TM7 Van der Waals
SOMATOSTATIN Y302 7.43x42 TM7 polar (hydrogen bond)
SOMATOSTATIN Y302 7.43x42 TM7 Van der Waals

Ligands

SOMATOSTATIN

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Residue Diagrams

T N G C L G I I C V V F Y I F T L V A N 1 L N L A I A D E L F M L G L P F L A M Q 2 V T L C F I S T F Q N I G D V T M V V R 3 A K M I T M A V W G V S L L V I L P I 4 Y C L C I I T L P V L F G L I F T Y I I F 5 S I V V A V F I F C W L P F Y I F N V S 6 I P N A C S N A Y T L V V V F D F M G 7
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ICL1 A K M K ICL1ECL1 V H W P F ECL1ICL2 P I K S A K W R ICL2ECL2 G L R S N Q W G R S S C T I N W P G E ECL2ICL3 G I R V G ICL3ECL3 A I S P ECL3N-term M D M A D E P L N G S H T W L S I P F D L N G S V V S T N T S N Q T E P Y Y D N-termC-term L V K V S G T D D G E R S D S K Q D K S R L N E T T E T Q R T L L N G D L Q T S I C-term L T S N A V L T F I Y F V V C I I G L C G N T L V I Y V I L R Y T I T N I Y I L N L A I A D E L F M L G L P F L A M Q V A L G K A I C R V V M T V D G I N Q F T S I F C L T V M S I D R Y L A V V H R P R T A K M I T M A V W G V S L L V I L P I M I Y A S G A W Y T G F I I Y T F I L G F L V P L T I I C L C Y L F I I I K V K S S S S K R K K S E K K V T R M V S I V V A V F I F C W L P F Y I F N V S S V S M T P A L K G M F D F V V V L T Y A N S C A N P I L Y A F L S D N F Q N F K K S V L C
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Residue Table


GPCRdb(A)
GPCRdb(A)
SST2 receptor
TM3
3x36 3.36x36 Q126
ECL2
45x50 45.50x50 C193
45x51 45.51x51 T194
45x52 45.52x52 I195
TM5
5x36 5.35x36 Y205
5x39 5.38x39 F208
5x40 5.39x40 I209
5x43 5.42x43 T212
TM6
6x51 6.51x51 F272
6x54 6.54x54 F275
6x55 6.55x55 N276
6x58 6.58x58 S279
TM7
7x34 7.35x34 F294
7x42 7.43x42 Y302