PDB
7WV9
Resolution
3.4 Å
Released
June 15, 2022
Receptor
CB1
Class
A
Species
Homo sapiens
Ligands
ZCZ011
CP55940
Function
PAM
Agonist
Reference
10.1038/S41589-022-01038-Y
ZCZ011 CP55940

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Ligand Amino Acid Generic Number Segment Interaction Type
ZCZ011 L165 2.52x52 TM2 hydrophobic
ZCZ011 I169 2.56x56 TM2 hydrophobic
CP55940 F170 2.57x57 TM2 aromatic (edge-to-face)
CP55940 S173 2.60x60 TM2 polar (hydrogen bond)
CP55940 F174 2.61x61 TM2 Van der Waals
CP55940 F177 2.64x64 TM2 Van der Waals
CP55940 F177 2.64x64 TM2 hydrophobic
ZCZ011 F191 3.27x27 TM3 hydrophobic
CP55940 L193 3.29x29 TM3 hydrophobic
CP55940 L193 3.29x29 TM3 Van der Waals
CP55940 V196 3.32x32 TM3 Van der Waals
CP55940 T197 3.33x33 TM3 Van der Waals
CP55940 F200 3.36x36 TM3 Van der Waals
CP55940 F200 3.36x36 TM3 hydrophobic
ZCZ011 A248 4.57x57 TM4 hydrophobic
ZCZ011 V249 4.58x58 TM4 hydrophobic
CP55940 I267 ECL2 polar (hydrogen bond with backbone)
CP55940 I267 ECL2 Van der Waals
CP55940 F268 ECL2 hydrophobic
CP55940 F268 ECL2 Van der Waals
CP55940 P269 ECL2 Van der Waals
CP55940 L276 5.40x40 TM5 Van der Waals
CP55940 W279 5.43x43 TM5 hydrophobic
CP55940 W279 5.43x43 TM5 Van der Waals
CP55940 F379 7.35x34 TM7 hydrophobic
CP55940 F379 7.35x34 TM7 Van der Waals
CP55940 C386 7.42x41 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 R S L R C ICL1ECL1 F H R K D ECL1ICL2 P L A Y K R I V ICL2ECL2 W N C E K L Q S V C S D I F P H I ECL2ICL3 T Q K S I I I H T S E D G K V Q V T R ICL3ECL3 K M ECL3N-term M K S I L D G L A D T T F R T I T T D L L Y V G S N D I Q Y E D I K G D M A S K L G Y F P Q K F P L T S F R G S P F Q E K M T A G D N P Q L V P A D Q V N I T E F Y N K S L S S F K E N E E N I Q C G E N F M D I E C F M V L N-termC-term S C E G T A Q P L D N S M G D S D C L H K H A N N A A S V H R A A E S C I K S T V K I A K V T M S V S T D T S A E A L C-term N P S Q Q L A I A V L S L T L G T F T V L E N L L V L C V I L H S R P S Y H F I G S L A V A D L L G S V I F V Y S F I D F H V S R N V F L F K L G G V T A S F T A S V G S L F L T A I D R Y I S I H R T R P K A V V A F C L M W T I A I V I A V L P L L G D E T Y L M F W I G V T S V L L L F I V Y A Y M Y I L W K A H S H A V R M I Q R G P D Q A R M D I R L A K T L V L I L V V L I I C W G P L L A I M V Y D V F G N K L I K T V F A F C S M L C L L N S T V N P I I Y A L R S K D F R S L R H A M F P
Helix box plot — Download: PNG | SVG L N E L V T F T G L T L S L V A I A L Q 1 G S L A V A D L L G S V I F V Y S F I D 2 L F L S G V S A T F S A T V G G L K F L 3 A V V A F C L M W T I A I V I A V L P L 4 Y A Y V I F L L L V S T V G I W F M L Y 5 V L I L V V L I I C W G P L L A I M V Y 6 I P N V T S N L L C L M S C F A F V T 7

GPCRdb(A)
GPCRdb(A)
CB1 receptor
TM2
2x52 2.52x52 L165
2x56 2.56x56 I169
2x57 2.57x57 F170
2x60 2.60x60 S173
2x61 2.61x61 F174
2x64 2.64x64 F177
TM3
3x27 3.27x27 F191
3x29 3.29x29 L193
3x32 3.32x32 V196
3x33 3.33x33 T197
3x36 3.36x36 F200
TM4
4x57 4.57x57 A248
4x58 4.58x58 V249
TM5
5x40 5.40x40 L276
5x43 5.43x43 W279
TM7
7x34 7.35x34 F379
7x41 7.42x41 C386