Structure information

CCR2

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7XA3

SPECIES

Homo sapiens

RESOLUTION

2.900

PREFERRED CHAIN

R

REFERENCE

10.1038/S41421-022-00403-4

PUBLICATION DATE

Aug. 24, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
C-C motif chemokine 2 A30 N-term polar (hydrogen bond with backbone)
C-C motif chemokine 2 A30 N-term Van der Waals
C-C motif chemokine 2 P31 N-term Van der Waals
C-C motif chemokine 2 P31 N-term hydrophobic
C-C motif chemokine 2 C32 N-term Van der Waals
C-C motif chemokine 2 H33 N-term polar (hydrogen bond with backbone)
C-C motif chemokine 2 H33 N-term Van der Waals
C-C motif chemokine 2 H33 N-term polar (hydrogen bond)
C-C motif chemokine 2 K38 1.28x28 TM1 Van der Waals
C-C motif chemokine 2 Y49 1.39x39 TM1 Van der Waals
C-C motif chemokine 2 W98 2.60x60 TM2 Van der Waals
C-C motif chemokine 2 W98 2.60x60 TM2 hydrophobic
C-C motif chemokine 2 T117 3.29x29 TM3 Van der Waals
C-C motif chemokine 2 T117 3.29x29 TM3 polar (hydrogen bond)
C-C motif chemokine 2 Y120 3.32x32 TM3 Van der Waals
C-C motif chemokine 2 Y120 3.32x32 TM3 hydrophobic
C-C motif chemokine 2 H121 3.33x33 TM3 polar (hydrogen bond)
C-C motif chemokine 2 D185 ECL2 polar (charge-assisted hydrogen bond)
C-C motif chemokine 2 C190 45.50x50 ECL2 polar (hydrogen bond with backbone)
C-C motif chemokine 2 C190 45.50x50 ECL2 polar (hydrogen bond)
C-C motif chemokine 2 G191 45.51x51 ECL2 Van der Waals
C-C motif chemokine 2 P192 45.52x52 ECL2 hydrophobic
C-C motif chemokine 2 P192 45.52x52 ECL2 Van der Waals
C-C motif chemokine 2 F194 ECL2 polar (hydrogen bond with backbone)
C-C motif chemokine 2 F194 ECL2 Van der Waals
C-C motif chemokine 2 R196 5.32x33 TM5 polar (charge-assisted hydrogen bond)
C-C motif chemokine 2 N199 5.35x36 TM5 polar (hydrogen bond)
C-C motif chemokine 2 N199 5.35x36 TM5 Van der Waals
C-C motif chemokine 2 Q269 6.61x61 TM6 Van der Waals
C-C motif chemokine 2 S275 ECL3 Van der Waals
C-C motif chemokine 2 T280 7.28x27 TM7 Van der Waals
C-C motif chemokine 2 D284 7.32x31 TM7 Van der Waals
C-C motif chemokine 2 T287 7.35x34 TM7 Van der Waals
C-C motif chemokine 2 Q288 7.36x35 TM7 Van der Waals
C-C motif chemokine 2 E291 7.39x38 TM7 Van der Waals

Ligands

C-C motif chemokine 2

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Residue Diagrams

M N G V F G F I F V L S Y L P P L L Q A 1 L N L A I S D L L F L I T L P L W A H S 2 L I I F F I G G F Y G I H Y L G T F L K 3 G V V T S V I T W L V A V F A S V P G 4 Y C I V M I L L P L V L G L I N R M I T H 5 F T I M I V Y F L F W T P Y N I V I L L 6 I P N I C C H T M G L T E T V Q T A Q 7
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ICL1 K K L K ICL1ECL1 E W V F ECL1ICL2 A V F A L K A R ICL2ECL2 K C Q K E D S V Y V C G P Y F ECL2ICL3 R ICL3ECL3 L S N C ECL3N-term M L S T S R S R F I R N T N E S G E E V T T F F D Y D Y G A P C H K F D N-termC-term G C R I A P L Q K P V C G G P G V R P G K N V K V T T Q G L L D G R G K G K S I G R A P E A S L Q D K E G A C-term V K Q I G A Q L L P P L Y S L V F I F G F V G N M L V V L I L I N C C L T D I Y L L N L A I S D L L F L I T L P L W A H S A A N G N A M C K L F T G L Y H I G Y F G G I F F I I L L T I D R Y L A I V H T V T F G V V T S V I T W L V A V F A S V P G I I F T P R G W N N F H T I M R N I L G L V L P L L I M V I C Y S G I L K T L L R C N E K K R H R A V R V I F T I M I V Y F L F W T P Y N I V I L L N T F Q E F F G E S T S Q L D Q A T Q V T E T L G M T H C C I N P I I Y A F V G E K F H I F R S L A L
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Residue Table


GPCRdb(A)
GPCRdb(A)
CCR2
TM1
1x28 1.28x28 K38
1x39 1.39x39 Y49
TM2
2x60 2.60x60 W98
TM3
3x29 3.29x29 T117
3x32 3.32x32 Y120
3x33 3.33x33 H121
ECL2
45x50 45.50x50 C190
45x51 45.51x51 G191
45x52 45.52x52 P192
TM5
5x33 5.32x33 R196
5x36 5.35x36 N199
TM6
6x61 6.61x61 Q269
TM7
7x27 7.28x27 T280
7x31 7.32x31 D284
7x34 7.35x34 T287
7x35 7.36x35 Q288
7x38 7.39x38 E291