Structure information

GAL2 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7XBD

SPECIES

Homo sapiens

RESOLUTION

3.110

PREFERRED CHAIN

A

REFERENCE

10.1371/JOURNAL.PBIO.3001714

PUBLICATION DATE

July 13, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Galanin, Human I85 2.64x63 TM2 hydrophobic
Galanin, Human D89 ECL1 polar (hydrogen bond with backbone)
Galanin, Human D89 ECL1 Van der Waals
Galanin, Human G90 23.49x49 ECL1 Van der Waals
Galanin, Human H102 3.29x29 TM3 polar (hydrogen bond)
Galanin, Human H102 3.29x29 TM3 Van der Waals
Galanin, Human Y164 ECL2 hydrophobic
Galanin, Human Y164 ECL2 Van der Waals
Galanin, Human H176 45.51x51 ECL2 Van der Waals
Galanin, Human P177 45.52x52 ECL2 Van der Waals
Galanin, Human P177 45.52x52 ECL2 hydrophobic
Galanin, Human R184 5.35x36 TM5 polar (charge-assisted hydrogen bond)
Galanin, Human V259 6.58x58 TM6 hydrophobic
Galanin, Human V259 6.58x58 TM6 Van der Waals
Galanin, Human F264 ECL3 hydrophobic
Galanin, Human L266 ECL3 polar (hydrogen bond with backbone)
Galanin, Human L266 ECL3 Van der Waals
Galanin, Human T267 7.28x27 TM7 polar (hydrogen bond with backbone)
Galanin, Human T267 7.28x27 TM7 Van der Waals
Galanin, Human Y271 7.32x31 TM7 polar (hydrogen bond)
Galanin, Human Y271 7.32x31 TM7 aromatic (edge-to-face)
Galanin, Human Y271 7.32x31 TM7 Van der Waals
Galanin, Human R274 7.35x34 TM7 Van der Waals

Ligands

Galanin, Human

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Residue Diagrams

T N G V T G V L F I L A F L L P V I V A 1 L N L G V A D L C F I C L C V P F Q A T I 2 A A L T F S S A H M T L F I L F H V A K 3 A L A A I G L I W G L S L L F S G P Y 4 Y T L G L V L V P L L Y S F V F T C I D M 5 L I V A A L F C L C W M P H H A L I L C 6 I P N V C S N A Y S V L H S L I R L A 7
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ICL1 G Q A V ICL1ECL1 D G W V F ECL1ICL2 P L H S R E L R ICL2ECL2 R Q S Q L A N L T V C H P A W ECL2ICL3 A A ICL3ECL3 Q F P L ECL3N-term M N V S G C P G A G N A S Q A G G G G G W H N-termC-term G L L G R A P G R A S G R V C A A A R G T H S G S V L E R E S S D L L H M S E A A G A L R P C P G A S Q P C I L E P C P G P S W Q G P K A G D S I L T V D V A C-term P E A V I V P L L F A L I F L V G T V G N T L V L A V L L R G S T T N L F I L N L G V A D L C F I L C C V P F Q A T I Y T L G S L L C K A V H F L I F L T M H A S S F T L A A V S L D R Y L A I R Y T P R N A L A A I G L I W G L S L L F S G P Y L S Y Y S A P R R R A M D I C T F V F S Y L L P V L V L G L T Y A R T L R Y L W R A V D P V G S G A R R A K R K V T R M I L I V A A L F C L C W M P H H A L I L C V W F G T R A T Y A L R I L S H L V S Y A N S C V N P I V Y A L V S K H F R T F R K G I C A
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Residue Table


GPCRdb(A)
GPCRdb(A)
GAL2 receptor
TM2
2x63 2.64x63 I85
ECL1
23x49 23.49x49 G90
TM3
3x29 3.29x29 H102
ECL2
45x51 45.51x51 H176
45x52 45.52x52 P177
TM5
5x36 5.35x36 R184
TM6
6x58 6.58x58 V259
TM7
7x27 7.28x27 T267
7x31 7.32x31 Y271
7x34 7.35x34 R274