Structure information

GAL2 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

7XJK

SPECIES

Homo sapiens

RESOLUTION

3.300

PREFERRED CHAIN

F

REFERENCE

10.1073/PNAS.2121465119

PUBLICATION DATE

June 29, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
Galanin, Human Q82 2.61x60 TM2 polar (hydrogen bond)
Galanin, Human Q82 2.61x60 TM2 Van der Waals
Galanin, Human I85 2.64x63 TM2 polar (hydrogen bond with backbone)
Galanin, Human I85 2.64x63 TM2 Van der Waals
Galanin, Human Y86 2.65x64 TM2 Van der Waals
Galanin, Human Y86 2.65x64 TM2 hydrophobic
Galanin, Human D89 ECL1 Van der Waals
Galanin, Human G90 23.49x49 ECL1 Van der Waals
Galanin, Human G90 23.49x49 ECL1 polar (hydrogen bond with backbone)
Galanin, Human H102 3.29x29 TM3 Van der Waals
Galanin, Human Y164 ECL2 Van der Waals
Galanin, Human Y164 ECL2 hydrophobic
Galanin, Human L169 ECL2 hydrophobic
Galanin, Human L169 ECL2 Van der Waals
Galanin, Human C175 45.50x50 ECL2 Van der Waals
Galanin, Human H176 45.51x51 ECL2 polar (hydrogen bond)
Galanin, Human H176 45.51x51 ECL2 polar (hydrogen bond)
Galanin, Human P177 45.52x52 ECL2 Van der Waals
Galanin, Human R184 5.35x36 TM5 polar (charge-assisted hydrogen bond)
Galanin, Human V259 6.58x58 TM6 Van der Waals
Galanin, Human V259 6.58x58 TM6 hydrophobic
Galanin, Human F264 ECL3 hydrophobic
Galanin, Human L266 ECL3 hydrophobic
Galanin, Human L266 ECL3 Van der Waals
Galanin, Human T267 7.28x27 TM7 Van der Waals
Galanin, Human T267 7.28x27 TM7 polar (hydrogen bond with backbone)
Galanin, Human T270 7.31x30 TM7 polar (hydrogen bond)
Galanin, Human Y271 7.32x31 TM7 aromatic (edge-to-face)
Galanin, Human Y271 7.32x31 TM7 polar (hydrogen bond with backbone)
Galanin, Human Y271 7.32x31 TM7 Van der Waals
Galanin, Human R274 7.35x34 TM7 Van der Waals

Ligands

Galanin, Human

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Residue Diagrams

T N G V T G V L F I L A F L L P V I V A 1 L N L G V A D L C F I C L C V P F Q A T I 2 A A L T F S S A H M T L F I L F H V A K 3 A L A A I G L I W G L S L L F S G P Y 4 Y T L G L V L V P L L Y S F V F T C I D M 5 L I V A A L F C L C W M P H H A L I L C 6 I P N V C S N A Y S V L H S L I R L A 7
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ICL1 G Q A V ICL1ECL1 D G W V F ECL1ICL2 P L H S R E L R ICL2ECL2 R Q S Q L A N L T V C H P A W ECL2ICL3 A A ICL3ECL3 Q F P L ECL3N-term M N V S G C P G A G N A S Q A G G G G G W H N-termC-term G L L G R A P G R A S G R V C A A A R G T H S G S V L E R E S S D L L H M S E A A G A L R P C P G A S Q P C I L E P C P G P S W Q G P K A G D S I L T V D V A C-term P E A V I V P L L F A L I F L V G T V G N T L V L A V L L R G S T T N L F I L N L G V A D L C F I L C C V P F Q A T I Y T L G S L L C K A V H F L I F L T M H A S S F T L A A V S L D R Y L A I R Y T P R N A L A A I G L I W G L S L L F S G P Y L S Y Y S A P R R R A M D I C T F V F S Y L L P V L V L G L T Y A R T L R Y L W R A V D P V G S G A R R A K R K V T R M I L I V A A L F C L C W M P H H A L I L C V W F G T R A T Y A L R I L S H L V S Y A N S C V N P I V Y A L V S K H F R T F R K G I C A
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Residue Table


GPCRdb(A)
GPCRdb(A)
GAL2 receptor
TM2
2x60 2.61x60 Q82
2x63 2.64x63 I85
2x64 2.65x64 Y86
ECL1
23x49 23.49x49 G90
TM3
3x29 3.29x29 H102
ECL2
45x50 45.50x50 C175
45x51 45.51x51 H176
45x52 45.52x52 P177
TM5
5x36 5.35x36 R184
TM6
6x58 6.58x58 V259
TM7
7x27 7.28x27 T267
7x30 7.31x30 T270
7x31 7.32x31 Y271
7x34 7.35x34 R274