PDB
7XWO
Resolution
2.7 Å
Released
May 31, 2023
Receptor
NK2
Class
A
Species
Homo sapiens
Ligand
Function
neurokinin A (Human)
Agonist
Reference
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Ligand Amino Acid Generic Number Segment Interaction Type
neurokinin A (Human) N86 2.57x57 TM2 polar (hydrogen bond)
neurokinin A (Human) N86 2.57x57 TM2 polar (hydrogen bond)
neurokinin A (Human) N90 2.61x61 TM2 polar (hydrogen bond)
neurokinin A (Human) Y93 2.64x64 TM2 polar (hydrogen bond)
neurokinin A (Human) H96 ECL1 aromatic (edge-to-face)
neurokinin A (Human) I114 3.33x33 TM3 hydrophobic
neurokinin A (Human) M117 3.36x36 TM3 hydrophobic
neurokinin A (Human) F118 3.37x37 TM3 Van der Waals
neurokinin A (Human) T173 ECL2 Van der Waals
neurokinin A (Human) D175 ECL2 polar (charge-charge)
neurokinin A (Human) K180 ECL2 Van der Waals
neurokinin A (Human) C181 45.50x50 ECL2 hydrophobic
neurokinin A (Human) H198 5.39x40 TM5 Van der Waals
neurokinin A (Human) Y266 6.51x51 TM6 Van der Waals
neurokinin A (Human) Y269 6.54x54 TM6 Van der Waals
neurokinin A (Human) F270 6.55x55 TM6 hydrophobic
neurokinin A (Human) Y280 ECL3 Van der Waals
neurokinin A (Human) C281 ECL3 Van der Waals
neurokinin A (Human) I285 7.31x30 TM7 hydrophobic
neurokinin A (Human) Q286 7.32x31 TM7 hydrophobic
neurokinin A (Human) Y289 7.35x34 TM7 polar (hydrogen bond)
neurokinin A (Human) Y289 7.35x34 TM7 aromatic (edge-to-face)
neurokinin A (Human) F293 7.39x38 TM7 Van der Waals

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Snake plot — Download: PNG | SVG
ICL1 R R M R ICL1ECL1 I W Y F ECL1ICL2 P F Q P R L ICL2ECL2 T V T M D Q G A T K C V V A W P E D ECL2ICL3 Q A H G ICL3ECL3 E D I Y C H ECL3N-term M G T C D I V T E A N I S S G P E S N T T G I T A F S M N-termC-term R C C P W V T P T K E D K L E L T P T T S L S T R V N R C H T K E T L F M A G D T A P S E A T S G E A G R P Q D G S G L W F G Y G L L A P T K T H V E I C-term P S W Q L A L W A T A Y L A L V L V A V T G N A I V I W I I L A H T V T N Y F I V N L A L A D L C M A A F N A A F N F V Y A S H N G R A F C Y F Q N L F P I T A M F V S I Y S M T A I A A D R Y M A I V H S A P S T K A V I A G I W L V A L A L A S P Q C F Y S S G G K T L L L Y H L V V I A L I Y F L P L A V M F V A Y S V I G L T L W R R A V P G H A N L R H L Q A M K K F V K T M V L V V L T F A I C W L P Y H L Y F I L G S F Q K F I Q Q V Y L A L F W L A M S S T M Y N P I I Y C C L N H R F R L F R S G A F
Helix box plot — Download: PNG | SVG A N G T V A V L V L A L Y A T A W L A L 1 V N L A L A D L C M A A F N A A F N F V 2 A T M S Y I S V F M A T I P F L N Q F Y 3 T K A V I A G I W L V A L A L A S P Q 4 Y A V F M V A L P L F Y I L A I V V L H Y 5 V L V V L T F A I C W L P Y H L Y F I L 6 I P N Y M T S S M A L W F L A L Y V Q 7

GPCRdb(A)
GPCRdb(A)
NK2 receptor
TM2
2x57 2.57x57 N86
2x61 2.61x61 N90
2x64 2.64x64 Y93
TM3
3x33 3.33x33 I114
3x36 3.36x36 M117
3x37 3.37x37 F118
ECL2
45x50 45.50x50 C181
TM5
5x40 5.39x40 H198
TM6
6x51 6.51x51 Y266
6x54 6.54x54 Y269
6x55 6.55x55 F270
TM7
7x30 7.31x30 I285
7x31 7.32x31 Q286
7x34 7.35x34 Y289
7x38 7.39x38 F293