Structure information

5-HT2C receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8DPG

SPECIES

Homo sapiens

RESOLUTION

3.600

PREFERRED CHAIN

A

REFERENCE

10.1016/J.CELREP.2022.111211

PUBLICATION DATE

Aug. 24, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
psilocin D134 3.32x32 TM3 polar (charge-assisted hydrogen bond)
psilocin V135 3.33x33 TM3 hydrophobic
psilocin V135 3.33x33 TM3 Van der Waals
psilocin S138 3.36x36 TM3 polar (hydrogen bond)
psilocin T139 3.37x37 TM3 polar (hydrogen bond)
psilocin F214 5.38x39 TM5 Van der Waals
psilocin F214 5.38x39 TM5 polar (hydrogen bond with backbone)
psilocin V215 5.39x40 TM5 Van der Waals
psilocin G218 5.42x43 TM5 polar (hydrogen bond with backbone)
psilocin G218 5.42x43 TM5 Van der Waals
psilocin S219 5.43x44 TM5 polar (hydrogen bond)
psilocin S219 5.43x44 TM5 polar (hydrogen bond with backbone)
psilocin A222 5.46x461 TM5 Van der Waals
psilocin W324 6.48x48 TM6 Van der Waals
psilocin F327 6.51x51 TM6 hydrophobic
psilocin F327 6.51x51 TM6 Van der Waals
psilocin N331 6.55x55 TM6 Van der Waals
psilocin V354 7.39x38 TM7 Van der Waals
psilocin Y358 7.43x42 TM7 polar (hydrogen bond)

Ligands

psilocin

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Residue Diagrams

I N G G I T M I I I I V I S L A P W N 1 M S L A I A D M L V G L L V M P L S L L A 2 A C L H M I S A T S F L V D L S I W V P 3 A I M K I A I V W A I S I G V S V P I 4 Y T I V M I T L P I F F A V F S G I L V F 5 G I V F F V F L I M W C P F F I T N I L 6 L P N I G S C V Y G I W V F V N L L K 7
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ICL1 K K L H ICL1ECL1 Y V W P L ECL1ICL2 P I E H S R F N ICL2ECL2 E E K V F V N N T T C V L N ECL2ICL3 G H T E E P P G L S L D F L K C C K R N T A E E E N S A N P N Q D Q N A R R R K K K E R R P R G T ICL3ECL3 E K S C ECL3N-term M V N L R N A V H S F L V H L I G L L V W Q S D I S V S P V A A I V T D I F N T S D G G R F K F P D G V Q N-termC-term N Y K V E K K P P V R Q I P R V A A T A L S G R E L N V N I Y R H T N E P V I E K A S D N E P G I E M Q V E N L E L P V N P S S V V S E R I S S V C-term N W P A L S I V I I I I M T I G G N I L V I M A V S M E N A T N Y F L M S L A I A D M L V G L L V M P L S L L A I L Y D P R Y L C P V W I S L D V L F S T A S I M H L C A I S L D R Y V A I R N S R T K A I M K I A I V W A I S I G V S V P I P V I G L R D D P N F V L I G S F V A F F I P L T I M V I T Y C L T I Y V L R R Q A L M L L H M Q A I N N E R K A S K V L G I V F F V F L I M W C P F F I T N I L S V L C N Q K L M E K L L N V F V W I G Y V C S G I N P L V Y T L F N K I F S N Y R R A Y L R C
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Residue Table


GPCRdb(A)
GPCRdb(A)
5-HT2C receptor
TM3
3x32 3.32x32 D134
3x33 3.33x33 V135
3x36 3.36x36 S138
3x37 3.37x37 T139
TM5
5x39 5.38x39 F214
5x40 5.39x40 V215
5x43 5.42x43 G218
5x44 5.43x44 S219
5x461 5.46x461 A222
TM6
6x48 6.48x48 W324
6x51 6.51x51 F327
6x55 6.55x55 N331
TM7
7x38 7.39x38 V354
7x42 7.43x42 Y358