Structure information

M3 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8EA0

SPECIES

Homo sapiens

RESOLUTION

2.560

PREFERRED CHAIN

A

REFERENCE

10.1038/S41586-022-05489-0

PUBLICATION DATE

Nov. 30, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
iperoxo Y149 3.33x33 TM3 hydrophobic
iperoxo V156 3.40x40 TM3 hydrophobic
iperoxo W200 4.57x57 TM4 hydrophobic
iperoxo A239 5.46x461 TM5 hydrophobic
iperoxo W504 6.48x48 TM6 hydrophobic
iperoxo Y507 6.51x51 TM6 hydrophobic
iperoxo N508 6.52x52 TM6 polar (hydrogen bond)
iperoxo N508 6.52x52 TM6 Van der Waals
iperoxo Y530 7.39x38 TM7 hydrophobic
iperoxo Y530 7.39x38 TM7 Van der Waals
iperoxo C533 7.42x41 TM7 Van der Waals
iperoxo Y534 7.43x42 TM7 Van der Waals
iperoxo Y534 7.43x42 TM7 hydrophobic

Ligands

iperoxo

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Residue Diagrams

I N G I I T V L A L I G T L F A I F V V 1 L S L A C A D L I I G I V S M N L F T T Y 2 V L L N M V S A N S A V Y D I A L W L D 3 A G V M I G L A W V I S F V L W A P A I 4 Y L I T M I T V P M Y F A A I A T G F T I 5 S A I L L A F I I T W T P Y N I M V L V 6 V P N V T S N I Y C L W Y G L N W F T 7
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ICL1 K Q L K ICL1ECL1 N R W A L ECL1ICL2 P L T Y R A K R ICL2ECL2 K R T V P P G E C F I Q F L S ECL2ICL3 Q A S G T E A E T E N F V H P T G S S R S C S S Y E L Q Q Q S M K R S N R R K Y G R C H F W F T T K S W K P S S E Q M D Q D H S S S D S W N N N D A A A S L E N S A S S D E E D I G S E T R A I Y S I V L K L P G H S T I L N S T K L P S S D N L Q V P E E E L G M V D L E R K A D K L Q A Q K S V D D G G S F P K S F S K L P I Q L E S A V D T A K T S D V N S S V G K S T A T L P L S F K E A T L A K R F A L K T R S Q I T K R K ICL3ECL3 D S C I ECL3N-term M T L H N N S T T S P L F P N I S S S W I H S P S D A G L P P G T V T H F G S Y N V S R A A G N F S S P D G T T D D P L G G H N-termC-term Q C D K K K R R K Q Q Y Q Q R Q S V I F H K R A P E Q A L C-term T V W Q V V F I A F L T G I L A L V T I I G N I L V I V S F K V N T V N N Y F L L S L A C A D L I I G V I S M N L F T T Y I I M G N L A C D L W L A I D Y V A S N A S V M N L L V I S F D R Y F S I T R T T K R A G V M I G L A W V I S F V L W A P A I L F W Q Y F V G E P T I T F G T A I A A F Y M P V T I M T I L Y W R I Y K E T E K R T K E L A G L R M S L V K E K K A A Q T L S A I L L A F I I T W T P Y N I M V L V N T F C P K T F W N L G Y W L C Y I N S T V N P V C Y A L C N K T F K M F R T T L L L C
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Residue Table


GPCRdb(A)
GPCRdb(A)
M3 receptor
TM3
3x33 3.33x33 Y149
3x40 3.40x40 V156
TM4
4x57 4.57x57 W200
TM5
5x461 5.46x461 A239
TM6
6x48 6.48x48 W504
6x51 6.51x51 Y507
6x52 6.52x52 N508
TM7
7x38 7.39x38 Y530
7x41 7.42x41 C533
7x42 7.43x42 Y534