Structure information

δ receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8F7S

SPECIES

Homo sapiens

RESOLUTION

3.000

PREFERRED CHAIN

R

REFERENCE

10.1016/J.CELL.2022.12.026

PUBLICATION DATE

Dec. 14, 2022

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
DELTORPHIN II K108 2.63x63 TM2 polar (charge-assisted hydrogen bond)
DELTORPHIN II W114 23.50x50 ECL1 Van der Waals
DELTORPHIN II W114 23.50x50 ECL1 aromatic (face-to-edge)
DELTORPHIN II L125 3.29x29 TM3 hydrophobic
DELTORPHIN II L125 3.29x29 TM3 Van der Waals
DELTORPHIN II D128 3.32x32 TM3 polar (charge-assisted hydrogen bond)
DELTORPHIN II Y129 3.33x33 TM3 aromatic (face-to-edge)
DELTORPHIN II Y129 3.33x33 TM3 polar (hydrogen bond)
DELTORPHIN II M132 3.36x36 TM3 Van der Waals
DELTORPHIN II M132 3.36x36 TM3 hydrophobic
DELTORPHIN II V197 ECL2 hydrophobic
DELTORPHIN II V197 ECL2 Van der Waals
DELTORPHIN II C198 45.50x50 ECL2 Van der Waals
DELTORPHIN II C198 45.50x50 ECL2 polar (hydrogen bond with backbone)
DELTORPHIN II L200 45.52x52 ECL2 Van der Waals
DELTORPHIN II K214 5.39x40 TM5 polar (charge-assisted hydrogen bond)
DELTORPHIN II V217 5.42x43 TM5 Van der Waals
DELTORPHIN II I277 6.51x51 TM6 Van der Waals
DELTORPHIN II V281 6.55x55 TM6 Van der Waals
DELTORPHIN II W284 6.58x58 TM6 hydrophobic
DELTORPHIN II W284 6.58x58 TM6 Van der Waals
DELTORPHIN II R291 ECL3 Van der Waals
DELTORPHIN II L300 7.35x34 TM7 hydrophobic
DELTORPHIN II L300 7.35x34 TM7 Van der Waals
DELTORPHIN II I304 7.39x38 TM7 hydrophobic
DELTORPHIN II I304 7.39x38 TM7 Van der Waals
DELTORPHIN II Y308 7.43x42 TM7 Van der Waals

Ligands

DELTORPHIN II

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Residue Diagrams

V N G L L G V A C V A S Y L A T I A I A 1 F N L A L A D A L A T S T L P F Q S A K 2 M T L T F I S T F M N Y Y D I S L V A K 3 A K L I N I C I W V L A S G V G V P I M 4 Y C V T I I L I P V V F A F L F V C I K T 5 L V V V G A F V V C W A P I H I F V I V 6 V P N L S S N A Y G L A I C L H L A A 7
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ICL1 T K M K ICL1ECL1 T W P F ECL1ICL2 P V K A L D F R ICL2ECL2 V T R P R D G A V V C M L Q F P S ECL2ICL3 R L L S G ICL3ECL3 D I D R R ECL3N-term M E P A P S A G A E L Q P P L F A N A S D A Y P S A C P S A G A N A S G P P N-termC-term P C G R P D P S S F S R A R E A T A R E R V T A C T P S D G P G G G A A A C-term G A R S A S S L A L A I A I T A L Y S A V C A V G L L G N V L V M F G I V R Y T A T N I Y I F N L A L A D A L A T S T L P F Q S A K Y L M E G E L L C K A V L S I D Y Y N M F T S I F T L T M M S V D R Y I A V C H T P A K A K L I N I C I W V L A S G V G V P I M V M A P S W Y W D T V T K I C V F L F A F V V P I L I I T V C Y G L M L L R L R S V S K E K D R S L R R I T R M V L V V V G A F V V C W A P I H I F V I V W T L V D P L V V A A L H L C I A L G Y A N S S L N P V L Y A F L D E N F R Q F K R C L C R K
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Residue Table


GPCRdb(A)
GPCRdb(A)
δ receptor
TM2
2x63 2.63x63 K108
ECL1
23x50 23.50x50 W114
TM3
3x29 3.29x29 L125
3x32 3.32x32 D128
3x33 3.33x33 Y129
3x36 3.36x36 M132
ECL2
45x50 45.50x50 C198
45x52 45.52x52 L200
TM5
5x40 5.39x40 K214
5x43 5.42x43 V217
TM6
6x51 6.51x51 I277
6x55 6.55x55 V281
6x58 6.58x58 W284
TM7
7x34 7.35x34 L300
7x38 7.39x38 I304
7x42 7.43x42 Y308