Structure information

PTH1 receptor

PROTEIN CLASS

Class B1 (Secretin)

PDB CODE

8FLR

SPECIES

Homo sapiens

RESOLUTION

2.940

PREFERRED CHAIN

R

REFERENCE

10.1016/J.STR.2023.04.002

PUBLICATION DATE

April 26, 2023

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
PTHrP[1-36] V31 N-term hydrophobic
PTHrP[1-36] M32 N-term Van der Waals
PTHrP[1-36] M32 N-term polar (hydrogen bond with backbone)
PTHrP[1-36] T33 N-term Van der Waals
PTHrP[1-36] K34 N-term Van der Waals
PTHrP[1-36] Q37 N-term Van der Waals
PTHrP[1-36] I38 N-term hydrophobic
PTHrP[1-36] I38 N-term Van der Waals
PTHrP[1-36] D113 N-term Van der Waals
PTHrP[1-36] I135 N-term Van der Waals
PTHrP[1-36] I135 N-term hydrophobic
PTHrP[1-36] Y136 N-term Van der Waals
PTHrP[1-36] D137 N-term polar (charge-assisted hydrogen bond)
PTHrP[1-36] F138 N-term hydrophobic
PTHrP[1-36] F138 N-term Van der Waals
PTHrP[1-36] A165 N-term Van der Waals
PTHrP[1-36] N166 N-term Van der Waals
PTHrP[1-36] Y167 N-term polar (hydrogen bond with backbone)
PTHrP[1-36] Y167 N-term Van der Waals
PTHrP[1-36] S168 N-term Van der Waals
PTHrP[1-36] V171 N-term Van der Waals
PTHrP[1-36] R181 1.33x33 TM1 polar (charge-assisted hydrogen bond)
PTHrP[1-36] F184 1.36x36 TM1 Van der Waals
PTHrP[1-36] F184 1.36x36 TM1 hydrophobic
PTHrP[1-36] L187 1.39x39 TM1 hydrophobic
PTHrP[1-36] Y191 1.43x43 TM1 Van der Waals
PTHrP[1-36] Y195 1.47x47 TM1 Van der Waals
PTHrP[1-36] Y195 1.47x47 TM1 polar (hydrogen bond)
PTHrP[1-36] R233 2.60x60 TM2 Van der Waals
PTHrP[1-36] K240 2.67x67 TM2 Van der Waals
PTHrP[1-36] Y245 2.72x72 TM2 hydrophobic
PTHrP[1-36] Y245 2.72x72 TM2 Van der Waals
PTHrP[1-36] F288 3.36x36 TM3 hydrophobic
PTHrP[1-36] F288 3.36x36 TM3 Van der Waals
PTHrP[1-36] L289 3.37x37 TM3 Van der Waals
PTHrP[1-36] L289 3.37x37 TM3 hydrophobic
PTHrP[1-36] L292 3.40x40 TM3 Van der Waals
PTHrP[1-36] L292 3.40x40 TM3 hydrophobic
PTHrP[1-36] D353 45.52x52 ECL2 polar (charge-assisted hydrogen bond)
PTHrP[1-36] D353 45.52x52 ECL2 polar (hydrogen bond with backbone)
PTHrP[1-36] L354 ECL2 Van der Waals
PTHrP[1-36] L354 ECL2 hydrophobic
PTHrP[1-36] S355 ECL2 Van der Waals
PTHrP[1-36] K360 5.36x37 TM5 Van der Waals
PTHrP[1-36] Q364 5.40x40 TM5 polar (hydrogen bond)
PTHrP[1-36] Q364 5.40x40 TM5 polar (hydrogen bond)
PTHrP[1-36] I367 5.43x43 TM5 Van der Waals
PTHrP[1-36] L368 5.44x44 TM5 hydrophobic
PTHrP[1-36] L368 5.44x44 TM5 Van der Waals
PTHrP[1-36] M425 6.57x57 TM6 Van der Waals
PTHrP[1-36] M425 6.57x57 TM6 polar (hydrogen bond with backbone)
PTHrP[1-36] T427 6.59x59 TM6 Van der Waals
PTHrP[1-36] T427 6.59x59 TM6 polar (hydrogen bond with backbone)
PTHrP[1-36] Y429 ECL3 polar (hydrogen bond)
PTHrP[1-36] Y429 ECL3 Van der Waals
PTHrP[1-36] T430 ECL3 Van der Waals
PTHrP[1-36] T430 ECL3 polar (hydrogen bond with backbone)
PTHrP[1-36] V432 ECL3 Van der Waals
PTHrP[1-36] W437 7.35x34 TM7 polar (hydrogen bond)
PTHrP[1-36] W437 7.35x34 TM7 polar (hydrogen bond)
PTHrP[1-36] Q440 7.38x37 TM7 Van der Waals
PTHrP[1-36] Q440 7.38x37 TM7 polar (hydrogen bond)
PTHrP[1-36] M441 7.39x38 TM7 polar (hydrogen bond)
PTHrP[1-36] E444 7.42x41 TM7 Van der Waals
PTHrP[1-36] M445 7.43x42 TM7 Van der Waals
PTHrP[1-36] M445 7.43x42 TM7 hydrophobic

Ligands

PTHrP[1-36]

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Residue Diagrams

T L S A L S V S Y G V T Y I M G L R D F 1 M H L F L S F M L R A V S I F V K D A V 2 V L I W Y Y N T A L F Y L F F T V A V R 3 Y L W G F T V G F W G L P A V F V A V W V 4 F L I F N L V I S A L I P V Q I I W K K N 5 L V L M P L F G V H Y I V F M A T 6 I A V F F G Q F S N F L M E Y H M Q V 7
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ICL1 R R L H ICL1ECL1 L D E A E R L T E E E L R A I A Q A P P P P A T A A A ECL1ICL2 A F F ICL2ECL2 N T G C W D L S S ECL2ICL3 R E T N A G R C ICL3ECL3 P Y T E V S ECL3N-term M G T A R I A P G L A L L L C C P V L S S A Y A L V D A D D V M T K E E Q I F L L H R A Q A Q C E K R L K E V L Q R P A S I M E S D K G W T S A S T S G K P R K D K A S G K L Y P E S E E D K E A P T G S R Y R G R P C L P E W D H I L C W P L G A P G E V V A V P C P D Y I Y D F N H K G H A Y R R C D R N G S W E L V P G H N R T W A N Y S E C V K N-termC-term S G S S S Y S Y G P M V S H T S V T N V G P R V G L G L P L S P R L L P T A T T N G H P Q L P G H A K P G T P A L E T L E T T P P A M A A P K D D G F L N G S C S G L D E E A S G P E R P P A L L Q E E W E T V M C-term F L T N E T R E R E V F D R L G M I Y T V G Y S V S L A S L T V A V L I L A Y F C T R N Y I H M H L F L S F M L R A V S I F V K D A V L Y S G A T G Y A G C R V A V T F F L Y F L A T N Y Y W I L V E G L Y L H S L I F M S E K K Y L W G F T V F G W G L P A V F V A V W V S V R A T L A G N K K W I I Q V P I L A S I V L N F I L F I N I V R V L A T K L D T R Q Q Y R K L L K S T L V L M P L F G V H Y I V F M A T G T L W Q V Q M H Y E M L F N S F Q G F F V A I I Y C F C N G E I K K W T L K R K V Q A E S W S R A L D F A R
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Residue Table


GPCRdb(A)
GPCRdb(B)
PTH1 receptor
TM1
1x29 1.33x33 R181
1x32 1.36x36 F184
1x35 1.39x39 L187
1x39 1.43x43 Y191
1x43 1.47x47 Y195
TM2
2x53 2.60x60 R233
2x60 2.67x67 K240
2x65 2.72x72 Y245
TM3
3x32 3.36x36 F288
3x33 3.37x37 L289
3x36 3.40x40 L292
ECL2
45x52 45.52x52 D353
TM5
5x41 5.36x37 K360
5x44 5.40x40 Q364
5x47 5.43x43 I367
5x48 5.44x44 L368
TM6
6x52 6.57x57 M425
6x54 6.59x59 T427
TM7
7x30 7.35x34 W437
7x33 7.38x37 Q440
7x34 7.39x38 M441
7x37 7.42x41 E444
7x38 7.43x42 M445