Structure information

MC5 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8IOD

SPECIES

Homo sapiens

RESOLUTION

2.590

PREFERRED CHAIN

R

REFERENCE

10.1107/S0907444909042073

PUBLICATION DATE

Sept. 20, 2023

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
PG-901 E92 2.60x60 TM2 polar (charge-assisted hydrogen bond)
PG-901 T95 2.63x63 TM2 Van der Waals
PG-901 I96 2.64x64 TM2 hydrophobic
PG-901 I96 2.64x64 TM2 Van der Waals
PG-901 V111 3.21x21 TM3 hydrophobic
PG-901 V111 3.21x21 TM3 Van der Waals
PG-901 D115 3.25x25 TM3 polar (charge-assisted hydrogen bond)
PG-901 N116 3.26x26 TM3 Van der Waals
PG-901 D119 3.29x29 TM3 polar (charge-assisted hydrogen bond)
PG-901 I122 3.32x32 TM3 Van der Waals
PG-901 I122 3.32x32 TM3 hydrophobic
PG-901 C123 3.33x33 TM3 hydrophobic
PG-901 C123 3.33x33 TM3 Van der Waals
PG-901 V126 3.36x36 TM3 hydrophobic
PG-901 F177 4.60x60 TM4 Van der Waals
PG-901 I178 4.61x61 TM4 Van der Waals
PG-901 I178 4.61x61 TM4 polar (hydrogen bond with backbone)
PG-901 S181 ECL2 polar (hydrogen bond)
PG-901 I187 5.40x40 TM5 hydrophobic
PG-901 I187 5.40x40 TM5 Van der Waals
PG-901 L190 5.43x43 TM5 Van der Waals
PG-901 L190 5.43x43 TM5 hydrophobic
PG-901 F254 6.51x51 TM6 hydrophobic
PG-901 F254 6.51x51 TM6 Van der Waals
PG-901 H257 6.54x54 TM6 polar (hydrogen bond)
PG-901 H257 6.54x54 TM6 Van der Waals
PG-901 L258 6.55x55 TM6 hydrophobic
PG-901 M261 6.58x58 TM6 polar (hydrogen bond)
PG-901 F277 7.35x34 TM7 hydrophobic
PG-901 F277 7.35x34 TM7 Van der Waals
PG-901 L281 7.39x38 TM7 hydrophobic
PG-901 L281 7.39x38 TM7 Van der Waals

Ligands

PG-901

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Residue Diagrams

I N E L L S I V G L T L F V E V A 1 C S L A V A D M L V S M S S A W E T I T 2 A L L S C M S A V V S I C I M S D F V N 3 S G A I I A G I W A F C T G C G I V F I 4 Y L S V L L F L M A F F M S I L C L I V 5 T M L L G V F T V C W A P F F L H L T L 6 L P D M V S N C M I L I L Y M N F H 7
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ICL1 K N L H ICL1ECL1 K H L V I ECL1ICL2 A L R Y H H I M ICL2ECL2 E ECL2ICL3 L P G A S S A R ICL3ECL3 P Q N L Y C S R F M S ECL3N-term M N S S F H L H F L D L N L N A T E G N L S G P N V K N K S S P C E D M G I N-termC-term G F R I A C S F P R R D C-term A V E V F L T L G V I S L L E N I L V I G A I V K N S P M Y F F V C S L A V A D M L V S M S S A W E T I T I Y L L N N A D A F V R H I D N V F D S M I C I S V V A S M C S L L A I A V D R Y V T I F Y T A R R S G A I I A G I W A F C T G C G I V F I L Y S S T Y V I L C L I S M F F A M L F L L V S L Y I H M F L L A R T H V K R I A A Q R T S M Q G A V T V T M L L G V F T V C W A P F F L H L T L M L S C H F N M Y L I L I M C N S V M D P L I Y A F R S Q E F K E R M R K T I I C C
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Residue Table


GPCRdb(A)
GPCRdb(A)
MC5 receptor
TM2
2x60 2.60x60 E92
2x63 2.63x63 T95
2x64 2.64x64 I96
TM3
3x21 3.21x21 V111
3x25 3.25x25 D115
3x26 3.26x26 N116
3x29 3.29x29 D119
3x32 3.32x32 I122
3x33 3.33x33 C123
3x36 3.36x36 V126
TM4
4x60 4.60x60 F177
4x61 4.61x61 I178
TM5
5x40 5.40x40 I187
5x43 5.43x43 L190
TM6
6x51 6.51x51 F254
6x54 6.54x54 H257
6x55 6.55x55 L258
6x58 6.58x58 M261
TM7
7x34 7.35x34 F277
7x38 7.39x38 L281