PDB
8IQ4
Resolution
2.7 Å
Released
Jan. 31, 2024
Receptor
FP
Class
A
Species
Homo sapiens
Ligand
Function
Carboprost tromethamine
Agonist
Reference
10.1038/S41467-023-43922-8

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Ligand Amino Acid Generic Number Segment Interaction Type
Carboprost tromethamine S33 1.39x39 TM1 polar (hydrogen bond)
Carboprost tromethamine F36 1.42x42 TM1 Van der Waals
Carboprost tromethamine M37 1.43x43 TM1 Van der Waals
Carboprost tromethamine G80 2.53x53 TM2 Van der Waals
Carboprost tromethamine H81 2.54x54 TM2 polar (hydrogen bond)
Carboprost tromethamine N84 2.57x57 TM2 hydrophobic
Carboprost tromethamine G85 2.58x58 TM2 Van der Waals
Carboprost tromethamine A88 2.61x61 TM2 hydrophobic
Carboprost tromethamine Y92 2.65x65 TM2 hydrophobic
Carboprost tromethamine Y92 2.65x65 TM2 polar (hydrogen bond)
Carboprost tromethamine F111 3.28x28 TM3 hydrophobic
Carboprost tromethamine M115 3.32x32 TM3 hydrophobic
Carboprost tromethamine S118 3.35x35 TM3 Van der Waals
Carboprost tromethamine G119 3.36x36 TM3 Van der Waals
Carboprost tromethamine T184 ECL2 polar (hydrogen bond)
Carboprost tromethamine W185 ECL2 hydrophobic
Carboprost tromethamine F187 45.51x51 ECL2 Van der Waals
Carboprost tromethamine W262 6.48x48 TM6 hydrophobic
Carboprost tromethamine F265 6.51x51 TM6 hydrophobic
Carboprost tromethamine L287 7.36x35 TM7 Van der Waals
Carboprost tromethamine L290 7.39x38 TM7 hydrophobic
Carboprost tromethamine R291 7.40x39 TM7 polar (charge-charge)
Carboprost tromethamine R291 7.40x39 TM7 polar (hydrogen bond)
Carboprost tromethamine A293 7.42x41 TM7 Van der Waals
Carboprost tromethamine T294 7.43x42 TM7 hydrophobic
Carboprost tromethamine Q297 7.46x46 TM7 hydrophobic

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ICL1 K S K ICL1ECL1 K E W I R F D Q S ECL1ICL2 P I F H S T K I ICL2ECL2 H R D Y K I Q A S R T W C F Y N T E D I K ECL2ICL3 Q H R Q G ICL3ECL3 G N H S L E ECL3N-term M S M N N S K Q L V S P A A A L L S N T T C Q T E N R L S N-termC-term I S L H I W E L S S I K N S L K V A A I S E S P V A E K S A S T C-term V F F S V I F M T V G I L S N S L A I A I L M K A Y Q R F R Q A S F L L L A S G L V I T D F F G H L I N G A I A V F V Y A S D N V L C S I F G I C M V F S G L C P L L L G S V M A I E R C I G V T K T S K H V K M M L S G V C L F A V F I A L L P I L G D W E D R F Y L L L F S F L G L L A L G V S L L C N A I T G I T L L R V K F K S Q R S H H L E M V I Q L L A I M C V S C I C W S P F L V T M A N I G I N T C E T T L F A L R M A T W N Q I L D P W V Y I L L R K A L Y K C C G V L K N L A S Q V H V
Helix box plot — Download: PNG | SVG S N S L I G V T M F I V S F F V 1 S G L V I T D F F G H L I N G A I A V F 2 V S G L L L P C L G S F V M C I G F I S 3 V K M M L S G V C L F A V F I A L L P I 4 I A N C L L S V G L A L L G L F S F L L 5 L A I M C V S C I C W S P F L V T M A N 6 W P D L I Q N W T A M R L A F L T T E 7

GPCRdb(A)
GPCRdb(A)
FP receptor
TM1
1x39 1.39x39 S33
1x42 1.42x42 F36
1x43 1.43x43 M37
TM2
2x53 2.53x53 G80
2x54 2.54x54 H81
2x57 2.57x57 N84
2x58 2.58x58 G85
2x61 2.61x61 A88
2x65 2.65x65 Y92
TM3
3x28 3.28x28 F111
3x32 3.32x32 M115
3x35 3.35x35 S118
3x36 3.36x36 G119
ECL2
45x51 45.51x51 F187
TM6
6x48 6.48x48 W262
6x51 6.51x51 F265
TM7
7x35 7.36x35 L287
7x38 7.39x38 L290
7x39 7.40x39 R291
7x41 7.42x41 A293
7x42 7.43x42 T294
7x46 7.46x46 Q297