PDB
8JIQ
Resolution
3.4 Å
Released
Sept. 13, 2023
Receptor
glucagon
Class
B1
Species
Homo sapiens
Ligand
Peptide 15 (P15)
Function
Agonist
Reference
10.1073/PNAS.2303696120

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Ligand Amino Acid Generic Number Segment Interaction Type
Peptide 15 (P15) M29 N-term polar (hydrogen bond)
Peptide 15 (P15) L32 N-term hydrophobic
Peptide 15 (P15) L32 N-term Van der Waals
Peptide 15 (P15) W36 N-term Van der Waals
Peptide 15 (P15) W36 N-term aromatic (face-to-edge)
Peptide 15 (P15) D63 N-term Van der Waals
Peptide 15 (P15) K64 N-term Van der Waals
Peptide 15 (P15) Y65 N-term hydrophobic
Peptide 15 (P15) R111 N-term polar (hydrogen bond with backbone)
Peptide 15 (P15) R111 N-term Van der Waals
Peptide 15 (P15) G112 N-term Van der Waals
Peptide 15 (P15) G112 N-term polar (hydrogen bond with backbone)
Peptide 15 (P15) W115 N-term Van der Waals
Peptide 15 (P15) S119 N-term Van der Waals
Peptide 15 (P15) A135 1.33x33 TM1 Van der Waals
Peptide 15 (P15) Y138 1.36x36 TM1 polar (hydrogen bond)
Peptide 15 (P15) Y138 1.36x36 TM1 Van der Waals
Peptide 15 (P15) Q142 1.40x40 TM1 Van der Waals
Peptide 15 (P15) Y145 1.43x43 TM1 Van der Waals
Peptide 15 (P15) Y145 1.43x43 TM1 aromatic (face-to-edge)
Peptide 15 (P15) L198 2.71x71 TM2 Van der Waals
Peptide 15 (P15) L198 2.71x71 TM2 hydrophobic
Peptide 15 (P15) R199 2.72x72 TM2 polar (charge-assisted hydrogen bond)
Peptide 15 (P15) Y202 2.75x75 TM2 polar (hydrogen bond)
Peptide 15 (P15) Y202 2.75x75 TM2 Van der Waals
Peptide 15 (P15) G207 ECL1 Van der Waals
Peptide 15 (P15) D208 ECL1 Van der Waals
Peptide 15 (P15) D209 ECL1 polar (charge-assisted hydrogen bond)
Peptide 15 (P15) Q293 ECL2 Van der Waals
Peptide 15 (P15) T296 45.52x52 ECL2 polar (hydrogen bond)
Peptide 15 (P15) T296 45.52x52 ECL2 Van der Waals
Peptide 15 (P15) S297 ECL2 polar (hydrogen bond)
Peptide 15 (P15) S297 ECL2 Van der Waals
Peptide 15 (P15) N298 ECL2 polar (hydrogen bond with backbone)
Peptide 15 (P15) N298 ECL2 Van der Waals
Peptide 15 (P15) W304 5.36x37 TM5 Van der Waals
Peptide 15 (P15) W304 5.36x37 TM5 hydrophobic
Peptide 15 (P15) L307 5.39x39 TM5 Van der Waals
Peptide 15 (P15) R308 5.40x40 TM5 Van der Waals
Peptide 15 (P15) V311 5.43x43 TM5 Van der Waals
Peptide 15 (P15) V311 5.43x43 TM5 hydrophobic
Peptide 15 (P15) D385 7.42x41 TM7 polar (charge-assisted hydrogen bond)
Peptide 15 (P15) L386 7.43x42 TM7 Van der Waals
Peptide 15 (P15) L386 7.43x42 TM7 hydrophobic

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ICL1 S K L H ICL1ECL1 Q K I G D D L S V S T W L S D G ECL1ICL2 A T L P E R ICL2ECL2 N V Q C W T S N D N M G F ECL2ICL3 R Q M H H T ICL3ECL3 E H A Q ECL3N-term M P P C Q P Q R P L L L L L L L L A C Q P Q V P S A Q V M D F L F E K W K L Y G D Q C H H N L S L L P P P T E L V C N R T F D K Y S C W P D T P A N T T A N I S C P W Y L P W H H K V Q H R F V F K R C G P D G Q W V R G P R G Q P W R D A S Q C Q M D G E E I E V N-termC-term T S N H R A S S S P G H G P P S K E L Q F G R G G G S Q D S S A E T P L A G G L P R L A E S P F C-term Q K E V A K M Y S S F Q V M Y T V G Y S L S L G A L L L A L A I L G G L C T R N A I H A N L F A S F V L K A S S V L V I D G L L R T R Y S A V A G C R V A A V F M Q Y G I V A N Y C W L L V E G L Y L H N L L G L S F F S L Y L G I G W G A P M L F V V P W A V V K C L F E W W I L R F P V F L A I L I N F F I F V R I V Q L L V A K L R A D Y K F R L A K S T L T L I P L L G V H E V V F A F V T D G T L R S A K L F F D L F L S S F Q G L L V A V L Y C F L N K E L R R W R L W E E V Q S E R W H R G K V L R N
Helix box plot — Download: PNG | SVG L L A G L S L S Y G V T Y M V Q F S S Y 1 A N L F A S F V L K A S S V L V I D G L 2 V L L W C Y N A V I G Y Q M F V A A V R 3 F F S L Y L G G I W G A P M L F V V P W A 4 F I F F N I L I A L F V P F R L I W W 5 L T L I P L L G V H E V V F A F V T D 6 V A V L L G Q F S S L F L D F F L K A 7

GPCRdb(A)
GPCRdb(B)
glucagon receptor
TM1
1x29 1.33x33 A135
1x32 1.36x36 Y138
1x36 1.40x40 Q142
1x39 1.43x43 Y145
TM2
2x64 2.71x71 L198
2x65 2.72x72 R199
2x68 2.75x75 Y202
ECL2
45x52 45.52x52 T296
TM5
5x41 5.36x37 W304
5x43 5.39x39 L307
5x44 5.40x40 R308
5x47 5.43x43 V311
TM7
7x37 7.42x41 D385
7x38 7.43x42 L386