Structure information

glucagon receptor

PROTEIN CLASS

Class B1 (Secretin)

PDB CODE

8JIT

SPECIES

Homo sapiens

RESOLUTION

2.910

PREFERRED CHAIN

R

PUBLICATION DATE

Sept. 6, 2023

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
MEDI0382 Q27 N-term polar (hydrogen bond with backbone)
MEDI0382 Q27 N-term Van der Waals
MEDI0382 V28 N-term polar (hydrogen bond with backbone)
MEDI0382 V28 N-term Van der Waals
MEDI0382 M29 N-term Van der Waals
MEDI0382 M29 N-term polar (hydrogen bond with backbone)
MEDI0382 L32 N-term Van der Waals
MEDI0382 L32 N-term hydrophobic
MEDI0382 W36 N-term hydrophobic
MEDI0382 W36 N-term Van der Waals
MEDI0382 K64 N-term Van der Waals
MEDI0382 Y65 N-term hydrophobic
MEDI0382 Y65 N-term Van der Waals
MEDI0382 Y84 N-term Van der Waals
MEDI0382 W87 N-term hydrophobic
MEDI0382 M123 N-term Van der Waals
MEDI0382 Q131 1.29x29 TM1 Van der Waals
MEDI0382 V134 1.32x32 TM1 Van der Waals
MEDI0382 A135 1.33x33 TM1 Van der Waals
MEDI0382 A135 1.33x33 TM1 hydrophobic
MEDI0382 Y138 1.36x36 TM1 hydrophobic
MEDI0382 Y138 1.36x36 TM1 Van der Waals
MEDI0382 S139 1.37x37 TM1 polar (hydrogen bond)
MEDI0382 F141 1.39x39 TM1 hydrophobic
MEDI0382 F141 1.39x39 TM1 Van der Waals
MEDI0382 Q142 1.40x40 TM1 polar (hydrogen bond)
MEDI0382 Q142 1.40x40 TM1 polar (hydrogen bond)
MEDI0382 V143 1.41x41 TM1 polar (hydrogen bond with backbone)
MEDI0382 V143 1.41x41 TM1 Van der Waals
MEDI0382 Y145 1.43x43 TM1 Van der Waals
MEDI0382 Y145 1.43x43 TM1 aromatic (face-to-edge)
MEDI0382 T146 1.44x44 TM1 polar (hydrogen bond)
MEDI0382 V147 1.45x45 TM1 polar (hydrogen bond with backbone)
MEDI0382 V147 1.45x45 TM1 Van der Waals
MEDI0382 Y149 1.47x47 TM1 Van der Waals
MEDI0382 Y149 1.47x47 TM1 polar (hydrogen bond)
MEDI0382 S150 1.48x48 TM1 polar (hydrogen bond)
MEDI0382 L151 1.49x49 TM1 hydrophobic
MEDI0382 L151 1.49x49 TM1 Van der Waals
MEDI0382 V191 2.64x64 TM2 hydrophobic
MEDI0382 V191 2.64x64 TM2 Van der Waals
MEDI0382 R199 2.72x72 TM2 polar (charge-assisted hydrogen bond)
MEDI0382 Y202 2.75x75 TM2 Van der Waals
MEDI0382 Y202 2.75x75 TM2 hydrophobic
MEDI0382 Q204 ECL1 polar (hydrogen bond with backbone)
MEDI0382 Q204 ECL1 Van der Waals
MEDI0382 I206 ECL1 polar (hydrogen bond with backbone)
MEDI0382 I206 ECL1 Van der Waals
MEDI0382 G207 ECL1 polar (hydrogen bond with backbone)
MEDI0382 G207 ECL1 Van der Waals
MEDI0382 D208 ECL1 Van der Waals
MEDI0382 V212 ECL1 Van der Waals
MEDI0382 W215 ECL1 hydrophobic
MEDI0382 W215 ECL1 Van der Waals
MEDI0382 Q232 3.37x37 TM3 Van der Waals
MEDI0382 I235 3.40x40 TM3 hydrophobic
MEDI0382 I235 3.40x40 TM3 Van der Waals
MEDI0382 Y239 3.44x44 TM3 polar (hydrogen bond)
MEDI0382 T296 45.52x52 ECL2 Van der Waals
MEDI0382 S297 ECL2 Van der Waals
MEDI0382 N298 ECL2 Van der Waals
MEDI0382 N298 ECL2 polar (hydrogen bond with backbone)
MEDI0382 W304 5.36x37 TM5 hydrophobic
MEDI0382 W304 5.36x37 TM5 Van der Waals
MEDI0382 V311 5.43x43 TM5 Van der Waals
MEDI0382 V311 5.43x43 TM5 hydrophobic
MEDI0382 R378 7.35x34 TM7 polar (charge-assisted hydrogen bond)
MEDI0382 K381 7.38x37 TM7 Van der Waals
MEDI0382 L382 7.39x38 TM7 Van der Waals
MEDI0382 L382 7.39x38 TM7 hydrophobic
MEDI0382 D385 7.42x41 TM7 Van der Waals
MEDI0382 L386 7.43x42 TM7 Van der Waals
MEDI0382 L386 7.43x42 TM7 hydrophobic

Ligands

MEDI0382

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Residue Diagrams

L L A G L S L S Y G V T Y M V Q F S S Y 1 A N L F A S F V L K A S S V L V I D G L 2 V L L W C Y N A V I G Y Q M F V A A V R 3 F F S L Y L G G I W G A P M L F V V P W A 4 F I F F N I L I A L F V P F R L I W W 5 L T L I P L L G V H E V V F A F V T D 6 V A V L L G Q F S S L F L D F F L K A 7
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ICL1 S K L H ICL1ECL1 Q K I G D D L S V S T W L S D G ECL1ICL2 A T L P E R ICL2ECL2 N V Q C W T S N D N M G F ECL2ICL3 R Q M H H T ICL3ECL3 E H A Q ECL3N-term M P P C Q P Q R P L L L L L L L L A C Q P Q V P S A Q V M D F L F E K W K L Y G D Q C H H N L S L L P P P T E L V C N R T F D K Y S C W P D T P A N T T A N I S C P W Y L P W H H K V Q H R F V F K R C G P D G Q W V R G P R G Q P W R D A S Q C Q M D G E E I E V N-termC-term T S N H R A S S S P G H G P P S K E L Q F G R G G G S Q D S S A E T P L A G G L P R L A E S P F C-term Q K E V A K M Y S S F Q V M Y T V G Y S L S L G A L L L A L A I L G G L C T R N A I H A N L F A S F V L K A S S V L V I D G L L R T R Y S A V A G C R V A A V F M Q Y G I V A N Y C W L L V E G L Y L H N L L G L S F F S L Y L G I G W G A P M L F V V P W A V V K C L F E W W I L R F P V F L A I L I N F F I F V R I V Q L L V A K L R A D Y K F R L A K S T L T L I P L L G V H E V V F A F V T D G T L R S A K L F F D L F L S S F Q G L L V A V L Y C F L N K E L R R W R L W E E V Q S E R W H R G K V L R N
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Residue Table


GPCRdb(A)
GPCRdb(B)
glucagon receptor
TM1
1x25 1.29x29 Q131
1x28 1.32x32 V134
1x29 1.33x33 A135
1x32 1.36x36 Y138
1x33 1.37x37 S139
1x35 1.39x39 F141
1x36 1.40x40 Q142
1x37 1.41x41 V143
1x39 1.43x43 Y145
1x40 1.44x44 T146
1x41 1.45x45 V147
1x43 1.47x47 Y149
1x44 1.48x48 S150
1x45 1.49x49 L151
TM2
2x57 2.64x64 V191
2x65 2.72x72 R199
2x68 2.75x75 Y202
TM3
3x33 3.37x37 Q232
3x36 3.40x40 I235
3x40 3.44x44 Y239
ECL2
45x52 45.52x52 T296
TM5
5x41 5.36x37 W304
5x47 5.43x43 V311
TM7
7x30 7.35x34 R378
7x33 7.38x37 K381
7x34 7.39x38 L382
7x37 7.42x41 D385
7x38 7.43x42 L386