Structure information

C5a1 receptor

PROTEIN CLASS

Class A (Rhodopsin)

PDB CODE

8JZZ

SPECIES

Homo sapiens

RESOLUTION

3.310

PREFERRED CHAIN

A

REFERENCE

10.1016/J.CELL.2023.09.020

PUBLICATION DATE

Oct. 18, 2023

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Ligand Interaction Browser

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Ligand Amino Acid Generic Number Segment Interaction Type
Ligand Amino Acid Generic Number Segment Interaction Type
C5a des-Arg P25 N-term polar (hydrogen bond with backbone)
C5a des-Arg P25 N-term Van der Waals
C5a des-Arg V26 N-term Van der Waals
C5a des-Arg V26 N-term polar (hydrogen bond with backbone)
C5a des-Arg D27 N-term polar (hydrogen bond with backbone)
C5a des-Arg D27 N-term polar (charge-assisted hydrogen bond)
C5a des-Arg K28 N-term polar (hydrogen bond with backbone)
C5a des-Arg K28 N-term polar (charge-assisted hydrogen bond)
C5a des-Arg T29 N-term Van der Waals
C5a des-Arg L92 2.60x60 TM2 Van der Waals
C5a des-Arg L92 2.60x60 TM2 hydrophobic
C5a des-Arg H100 ECL1 Van der Waals
C5a des-Arg L117 3.33x33 TM3 Van der Waals
C5a des-Arg L117 3.33x33 TM3 hydrophobic
C5a des-Arg M120 3.36x36 TM3 Van der Waals
C5a des-Arg R175 ECL2 polar (charge-assisted hydrogen bond)
C5a des-Arg R178 ECL2 Van der Waals
C5a des-Arg E180 ECL2 Van der Waals
C5a des-Arg Y181 ECL2 hydrophobic
C5a des-Arg Y181 ECL2 Van der Waals
C5a des-Arg F182 ECL2 Van der Waals
C5a des-Arg F182 ECL2 hydrophobic
C5a des-Arg L187 ECL2 hydrophobic
C5a des-Arg L187 ECL2 Van der Waals
C5a des-Arg G189 45.51x51 ECL2 Van der Waals
C5a des-Arg V190 45.52x52 ECL2 hydrophobic
C5a des-Arg V190 45.52x52 ECL2 Van der Waals
C5a des-Arg D191 ECL2 polar (charge-assisted hydrogen bond)
C5a des-Arg Y192 ECL2 Van der Waals
C5a des-Arg H194 ECL2 Van der Waals
C5a des-Arg E199 5.35x36 TM5 Van der Waals
C5a des-Arg R206 5.42x43 TM5 Van der Waals
C5a des-Arg Y258 6.51x51 TM6 Van der Waals
C5a des-Arg M265 6.58x58 TM6 Van der Waals
C5a des-Arg P270 ECL3 hydrophobic
C5a des-Arg L276 7.29x28 TM7 Van der Waals
C5a des-Arg D282 7.35x34 TM7 polar (charge-assisted hydrogen bond)
C5a des-Arg V286 7.39x38 TM7 hydrophobic
C5a des-Arg Y290 7.43x42 TM7 Van der Waals
C5a des-Arg Y290 7.43x42 TM7 hydrophobic

Ligands

C5a des-Arg

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Residue Diagrams

A N G L V G V L F V V A F I V L A L I D 1 L N L A V A D F L S C L A L P I L F T S 2 T A L L L I S A Y M N L L I L S P L I S 3 A W I A C A V A W G L A L L L T I P S 4 Y C I T L T L L P W L F G L V L R V I A V 5 V A V V A S F F I F W L P Y Q V T G I M 6 I P N I C C N I Y A F S V C L S D L K 7
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ICL1 A K R ICL1ECL1 H H W P F ECL1ICL2 P I W C Q N F R ICL2ECL2 V V R E E Y F P P K V L C G V D Y S H ECL2ICL3 R A T R S ICL3ECL3 E P S ECL3N-term M D S F N Y T T P D Y G H Y D D K D T L D L N T P V D K T S N T L N-termC-term L P S L L R N V L T E E S V V R E S K S F T R S T V D T M A Q K T Q A V C-term R V P D I L A L V I F A V V F L V G V L G N A L V V W V T A F E T I N A I W F L N L A V A D F L S C L A L P I L F T S I V Q H G G A A C S I L P S L I L L N M Y A S I L L L A T I S A D R F L L V F K G A G L A W I A C A V A W G L A L L L T I P S F L Y R D K R R E R A V A I V R L V L G F L W P L L T L T I C Y T F I L L R T W S R T K T L K V V V A V V A S F F I F W L P Y Q V T G I M M S F L S P T F L L L K K L D S L C V S F A Y I N C C I N P I I Y V V A G Q G F R K S Q G R L
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Residue Table


GPCRdb(A)
GPCRdb(A)
C5a1 receptor
TM2
2x60 2.60x60 L92
TM3
3x33 3.33x33 L117
3x36 3.36x36 M120
ECL2
45x51 45.51x51 G189
45x52 45.52x52 V190
TM5
5x36 5.35x36 E199
5x43 5.42x43 R206
TM6
6x51 6.51x51 Y258
6x58 6.58x58 M265
TM7
7x28 7.29x28 L276
7x34 7.35x34 D282
7x38 7.39x38 V286
7x42 7.43x42 Y290