PDB
8K4S
Resolution
2.9 Å
Released
Nov. 6, 2024
Receptor
MRGPRX4
Class
A
Species
Homo sapiens
Ligand
Function
DCA-3P
Agonist
Reference
10.1016/J.CELL.2024.10.001

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Ligand Amino Acid Generic Number Segment Interaction Type
DCA-3P R82 2.60x60 TM2 polar (charge-charge)
DCA-3P R86 2.64x64 TM2 polar (charge-charge)
DCA-3P R95 3.25x25 TM3 polar (charge-charge)
DCA-3P K96 3.26x26 TM3 hydrophobic
DCA-3P V99 3.29x29 TM3 hydrophobic
DCA-3P T103 3.33x33 TM3 Van der Waals
DCA-3P F107 3.37x37 TM3 Van der Waals
DCA-3P F153 ECL2 Van der Waals
DCA-3P L156 ECL2 hydrophobic
DCA-3P E157 ECL2 hydrophobic
DCA-3P P180 5.43x43 TM5 Van der Waals
DCA-3P V181 5.44x44 TM5 Van der Waals
DCA-3P F232 6.51x51 TM6 Van der Waals
DCA-3P L235 6.54x54 TM6 Van der Waals
DCA-3P G236 6.55x55 TM6 Van der Waals
DCA-3P A237 6.56x56 TM6 Van der Waals
DCA-3P I239 ECL3 hydrophobic
DCA-3P Y240 ECL3 hydrophobic
DCA-3P L246 ECL3 hydrophobic
DCA-3P Y254 7.35x34 TM7 hydrophobic

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Snake plot — Download: PNG | SVG
ICL1 R R ICL1ECL1 I N I ECL1ICL2 P I W Y R C R R P T ICL2ECL2 D F L F S G A ECL2ICL3 G S R K M ICL3ECL3 I Y R M H L N L E ECL3N-term M D P T V P V F G T K L T P I N G R E E T P C Y N N-termC-term Q R Q N R Q N L K L V L Q R A L Q D K P E V D K G E G Q L P E E S L E L S G S R L G P C-term Q T L S F T V L T C I I S L V G L T G N A V V L W L L G Y R M N A V S I Y I L N L A A A D F L F L S F Q I I R L P L R L S H L I R K I L V S V M T F P Y F T G L S M L S A I S T E R C L S V L W H L S A V V C V L L W G L S L L F S M L E W R F C D S S W C E T S D F I P V A W L I F L C V V L C V S S L V L L V R I L C P L T R L Y V T I L L T V L V F L L C G L P F G I L G A L V L Y C H V Y L V C M S L S S L N S S A N P I I Y F F V G S F R
Helix box plot — Download: PNG | SVG A N G T L G V L S I I C T L V T F S L T 1 L N L A A A D F L F L S F Q I I R L P L 2 A S L M S L G T F Y P F T M V S V L I K 3 S A V V C V L L W G L S L L F S M L E W 4 S S V C L V V C L F I L W A V P I F D S 5 L L T V L V F L L C G L P F G I L G A L 6 I P N A S S N L S S L S M C V L Y V H 7

GPCRdb(A)
GPCRdb(A)
MRGPRX4
TM2
2x60 2.60x60 R82
2x64 2.64x64 R86
TM3
3x25 3.25x25 R95
3x26 3.26x26 K96
3x29 3.29x29 V99
3x33 3.33x33 T103
3x37 3.37x37 F107
TM5
5x43 5.43x43 P180
5x44 5.44x44 V181
TM6
6x51 6.51x51 F232
6x54 6.54x54 L235
6x55 6.55x55 G236
6x56 6.56x56 A237
TM7
7x34 7.35x34 Y254