PDB
8RVW
Resolution
2.7 Å
Released
Jan. 8, 2025
Receptor
A2A
Class
A
Species
Homo sapiens
Ligand
StilSwitch3
Function
Antagonist
Reference
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Ligand Amino Acid Generic Number Segment Interaction Type
StilSwitch3 V84 3.32x32 TM3 polar (hydrogen bond)
StilSwitch3 L85 3.33x33 TM3 Van der Waals
StilSwitch3 L167 45.51x51 ECL2 Van der Waals
StilSwitch3 F168 45.52x52 ECL2 aromatic (face-to-face)
StilSwitch3 F168 45.52x52 ECL2 Van der Waals
StilSwitch3 E169 ECL2 Van der Waals
StilSwitch3 M177 5.38x40 TM5 polar (hydrogen bond)
StilSwitch3 W246 6.48x48 TM6 Van der Waals
StilSwitch3 L249 6.51x51 TM6 polar (hydrogen bond)
StilSwitch3 N253 6.55x55 TM6 polar (hydrogen bond)
StilSwitch3 N253 6.55x55 TM6 polar (hydrogen bond)
StilSwitch3 H264 ECL3 Van der Waals
StilSwitch3 L267 7.32x31 TM7 polar (hydrogen bond)
StilSwitch3 M270 7.35x34 TM7 hydrophobic
StilSwitch3 M270 7.35x34 TM7 Van der Waals
StilSwitch3 I274 7.39x38 TM7 polar (hydrogen bond)

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Snake plot — Download: PNG | SVG
ICL1 S N L Q ICL1ECL1 F C A ECL1ICL2 P L R Y N G L V ICL2ECL2 W N N C G Q P K E G K N H S Q G C G E G Q V A C L F E D V V ECL2ICL3 Q P L P G ICL3ECL3 P D C S H A ECL3C-term K A A G T S A R V L A A H G S D G E Q V S L R L N G H P P G V W A N G S A P H P E R R P N G Y A L G L V S G G S A Q E S Q G N T G L P D V E L L S H E L K G V C P E P P G L D D P L A Q D G A G V S C-term M P I M G S S V Y I T V E L A I A V L A I L G N V L V C W A V W L N N V T N Y F V V S L A A A D I A V G V L A I P F A I T I S T G A C H G C L F I A C F V L V L T Q S S I F S L L A I A I D R Y I A I R I T G T R A K G I I A I C W V L S F A I G L T P M L G P M N Y M V Y F N F F A C V L V P L L L M L G V Y L R I F L A A R R Q L K Q M E S E R A R S T L Q K E V H A A K S L A I I V G L F A L C W L P L H I I N C F T F F C P L W L M Y L A I V L S H T N S V V N P F I Y A Y R I R E F R K H V L P F F R Q T I I R S R Q Q E
Helix box plot — Download: PNG | SVG V N G L I A L V A I A L E V T I Y V S S 1 V S L A A A D I A V G L V A I P F A I T I 2 A L L S F I S S Q T L V L V F C A I F L 3 A K G I I A I C W V L S F A I G L T P M 4 Y V G L M L L L P V L V C A F F N F Y V M Y 5 A I I V G L F A L C W L P L H I I N C F 6 F P N V V S N T H S L V I A L Y M L W 7

GPCRdb(A)
GPCRdb(A)
A2A receptor
TM3
3x32 3.32x32 V84
3x33 3.33x33 L85
ECL2
45x51 45.51x51 L167
45x52 45.52x52 F168
TM5
5x40 5.38x40 M177
TM6
6x48 6.48x48 W246
6x51 6.51x51 L249
6x55 6.55x55 N253
TM7
7x31 7.32x31 L267
7x34 7.35x34 M270
7x38 7.39x38 I274